RESOURCE BROWSER TUTORIAL |
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If you are interested in learning how to access HIRN-related resources for a bioinformatics project please watch our instructional video on YouTube. |
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RECORDINGS OF MONTHLY WEBINARS |
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All of the recordings from the HIRN Monthly Webinars are available to view and download on YouTube. We encourage you to share with your lab and colleagues.
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The Immunology of Diabetes Society (IDS) Congress will hold a virtual meeting on November 1-4, 2021. At the Congress, scientists will present the latest research related to the immunology of type 1 diabetes and discuss rapidly evolving topics. The meeting will allow interaction with scientific colleagues and have mechanisms for trainees to present their work. Learn more HERE.
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We invite you to block the dates below for the upcoming annual nPOD meeting. For this meeting we are monitoring the situation and working through the challenges imposed by the COVID pandemic. We are hoping to be able to return to an in person meeting. Soon, you will hear updates regarding the proposed program, abstract submissions, registration information, and more. Please email us HERE with any questions regarding the meeting.
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dkNET Webinar
The dkNET (NIDDK Information Network) is inviting you to join them for a webinar "YCharOS: Antibody Characterization through Open Science." Many (most!) genes/proteins linked to disease phenotypes remain severely understudied [1]. Distinct open-science initiatives are needed to promote the exploration of currently understudied proteins, from the proper identification of research reagents [2], to the development of a chemical probes for every human protein [1]. We focus on the proper characterization of antibodies to guide researchers in selecting the most specific/selective antibodies for their needed application(s) [3].
Dr. Carl Laflamme, Senior Postdoctoral Fellow at the Montreal Neurological Institute (The Neuro, McGill University) in the laboratory of Peter McPherson, distinguished James McGill professor, will be presenting on Friday, October 22, 2021, 11 am - 12 pm PT. Learn more HERE
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Announcing the New Funding Program from the Innovative Science Accelerator Program (ISAC)
The Innovative Science Accelerator (ISAC) Program supports truly innovative, disruptive, risky research to accelerate breakthrough discoveries. SAC provides:
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Funding for small high-risk/high reward projects via a streamlined process to support cutting-edge research and accelerate true innovation in areas of science of interest to the Kidney-Urologic-Hematologic (KUH) research communities.
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Collaboration and Events for researchers and trainees to efficiently exchange ideas and resources to accelerate innovation.
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NHGRI FUNDING OPPORTUNITIES |
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The NIH National Human Genome Research Institute (NHGRI) has recently posted three funding opportunities. A pre-application community webinar will be held on September 10th – learn more HERE
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RFA-HG-21-029 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Production Research and Development Centers (UM1 Clinical trials not allowed)
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Application due date: November 1, 2021
RFA-HG-21-030 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Analysis and Validation Centers (U01 Clinical trials not allowed)
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Application due date: November 1, 2021
RFA-HG-21-031 - Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Resource and Administrative Coordinating Center (U24 Clinical trials not allowed)
- Application due date: November 1, 2021
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NIH FUNDING OPPORTUNITIES |
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RFA-DK-21-016: Characterization of Islet-derived Extracellular Vesicles for Improved Detection, Monitoring, Classification, and Treatment of Type 1 Diabetes (R01 Clinical Trial Not Allowed)
- Application due date: November 3, 2021
RFA-DK-21-017: High-Resolution Exploration of the Human Islet Tissue Environment [HIRN Human Pancreas Analysis Consortium (HPAC)] (U01 - Clinical Trial Not Allowed)
- Application due date: March 3, 2022
F31 PAR-19-378: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
F32 PAR-19-379: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
PAR-20-140: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
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Application due date: Standard dates apply
- Foreign applications are allowed
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Below is a summary of the most recent job postings by category (Faculty, Research Staff/Admin, Postdoc). Visit the HIRN Website for a full listing for job opportunities.
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Program Director for Integrative Physiology of Human Diabetes
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring a Program Director for Integrative Physiology of Human Diabetes. A scientist with strong managerial, communications and interpersonal skills, and experience in integrative physiology relevant to diabetes, is sought for the position of Program Director for Integrative Physiology in the Division of Diabetes, Endocrinology, and Metabolic Diseases (DDEMD) in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), at the National Institutes of Health. Research to be managed by the Director of DDEMD’s Integrative Physiology program is supported through multiple mechanisms, including regular research grants and cooperative agreements. Activities to be pursued include planning, establishing, and overseeing a wide range of goal-directed initiatives to expedite and enhance translational, pre-clinical and clinical research in diabetes. Apply HERE.
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Program Officials
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring program officials with expertise in translational research in any of the following four topic areas as they specifically relate to key questions in diabetes, endocrine or metabolic diseases:
· Integrative physiology of human diabetes, including physiology of counter-regulatory responses to hypoglycemia, mechanisms involved in regulation of peripheral metabolism, autonomic nervous system regulation of glucose and lipid metabolism, and basic and clinical studies investigating effects of bariatric surgery on diabetes and diabetes-related outcomes;
· Neuroscience of human behavior and behavior change, including brain and peripheral systems that impact the onset, severity or resolution of diabetes or obesity pathophysiology;
· Immune regulation and inflammation, including innate and adaptive immune mechanisms influencing peripheral insulin resistance in animal models and humans;
· Precision medicine in diabetes and obesity.
The mission of the Division of Diabetes, Endocrinology and Metabolic Diseases is to support broad-based research programs focused on both basic and clinical research in the areas of type 1 and type 2 diabetes and other metabolic diseases. Apply Here
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Staff Scientist
A staff scientist is sought to fill a position to work in the diabetes research and regenerative medicine laboratory of Dr. Jeffrey Millman at Washington University in St. Louis. The laboratory focuses on the generation insulin-producing pancreatic β cells for the study and treatment of diabetes. We have a wide diversity of projects involving stem cells differentiation, genetic engineering with CRISPR, disease modeling, transplantation into animal models of diabetes, biomedical engineering, bioinformatics, and single-cell sequencing technologies and has been very productive with publications in high impact journals. The ideal candidate would be able to provide high level support across multiple projects. Please send your CV, cover letter, and contact information with 3 references to Dr. Millman.
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Physician Scientist
The University of Chicago's Department of Medicine is searching for full-time physician scientist faculty members at any rank. Appointees will maintain a productive research program and provide patient care directly. Other responsibilities will include teaching and supervision of trainees and students. We are interested in applicants in any area of scientific investigation and clinical subspecialty, and especially welcome those whose research focus more broadly is in the areas of immunology/inflammation, diabetes, obesity, metabolism, sleep disorders, or cancer biology. Prior to the start of employment, qualified applicants must: 1) have a medical doctorate or equivalent, and 2) hold or be eligible for medical licensure in the State of Illinois. Please send your CV, cover letter, and contact information with 3 references to Dr. Mirmira.
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Scientific Data Curator
The Beckman Research Institute at City of Hope has an opportunity for a Research Associate II, under the direction of Dr. Kaddis. The candidate in this position will work directly with diabetes scientists around the world, to advance and promote the Human Islet Research Network (HIRN). Using related databases and content curation strategies, this individual will gather and generate required information needed to register, annotate, and publicize scientific resources in project registry systems. The applicant will be part of a multi-disciplinary team responsible for developing, managing, checking, and sharing the metadata needed to describe a scientific resource, such as biomedical datasets, biological reagents, documents (e.g. protocols), and/or technologies (e.g. assays).
The candidate will develop content using literature curation methodologies, biological ontologies, controlled vocabularies, and databases, but often requires direct interaction with and feedback from submitting laboratories, i.e. scientists. Metadata completeness and correctness is of primary importance; the applicant will organize and oversee existing registry data, as well as perform reviews of new or modified metadata submissions. Telework is an option. Please send your CV, cover letter, and contact information with 3 references to Dr. John Kaddis.
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Research Technician
A new Stem Cell and Genome Editing Core Facility situated within the Kieffer Research Group has an opportunity for a highly motivated and collaborative technician to support diverse regenerative medicine research initiatives. The candidate will assist with the day to-day operation of the Core, will generate human induced pluripotent cells (iPSCs), and will culture and differentiate human embryonic stem cells (ESCs) and iPSCs down pancreatic lineages. Please send your CV, cover letter, and contact information with 3 references to Dr. Tim Kieffer.
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Postdoctoral Position
A postdoctoral associate position is available at the Diabetes Research Institute of the University of Miami. The main lines of research in the Beta Cell Regeneration Lab revolve around the development of regenerative strategies for type 1 diabetes, including stem cell differentiation into insulin-producing β-cells and islet regeneration. In particular, our current research is focused on the induction of human pancreatic ductal BMP-responsive progenitor cells, which we have identified and characterized by lineage tracing (Klein et al., Diabetes, 2015; Qadir et al., Cell Reports, 2018); single-cell RNAseq and transplantation of sorted populations (Qadir et al., PNAS, 2020); and organotypic culture (human pancreatic slices) techniques (Qadir et al., Nature Comms, 2020). Our seminal contribution to the development of the latter has enabled for the first time the real-time monitoring of β-cell regeneration in an in vitro setting that resembles the native organ. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Juan Dominguez-Bendala.
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Postdoctoral Position
The Department of Medicine at the University of Miami, Miller School of Medicine, has an exciting opportunity for a full time Postdoctoral Associate. This Postdoctoral Associate position will support Dr. Joao Pedro Werneck with his investigations that focus on implementing in vivo tools to understand the thyroid gland physiology and how exercise impacts human pancreatic islets. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Joao Saar Werneck de Castro.
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Postdoctoral Position
City of Hope has a postdoctoral position available in the laboratory of Dr. Komatsu / Dr. Kandeel in the Department of Translational Research & Cellular Therapeutics. They are seeking a creative, experienced and highly collaborative postdoctoral associate with a strong interest in the translational research in Type 1 diabetes. The research goal for this position is to establish the extrahepatic islet transplantation strategy in animal models that can be translated into the clinical. Several projects are ongoing with highly productive collaborators including extramural engineers. By integrating our broad knowledge of islet physiology with engineering approaches, we seek to develop novel strategy of islet transplantation. These projects are led by the principal investigator with extensive clinical experience as translational researches. The selected candidate will take initiative in developing the new islet transplantation approaches using animal islet transplantation models. Candidates with clinical experience, beta cell biology and/or molecular biology, are particularly welcome to apply. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Hirotake Komatsu.
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Postdoctoral Position
Benaroya Research Institute’s Center for Interventional Immunology seeking outstanding clinical investigator for faculty position as well as post-doctorate candidates or research fellows interested in clinical/translational research in type 1 diabetes and/or autoimmunity. Please send your CV, cover letter, and contact information with 3 references to Dr. Carla Greenbaum.
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Postdoctoral Position
The MacDonald Lab at the University of Alberta in Edmonton, Canada is looking to fill two postdoctoral positions within one or more of the following areas: cell physiology, single-cell biology, cell imaging, electrophysiology, and computational biology. The positions will be held within the Department of Pharmacology and the Alberta Diabetes Institute (ADI), Canada’s largest stand-alone diabetes research centre. Successful candidates will have access to extensive resources for research through the MacDonald Lab, the ADI, and the University of Alberta Faculty of Medicine and Dentistry. This includes core facilities for molecular biology and biochemistry, sequencing and single-cell work, live-cell imaging, animal services, and more. Please send your CV, cover letter, and contact information with 3 references to Dr. Patrick McDonald.
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Postdoctoral Associate
The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. Please send your CV, cover letter, and contact information with 3 references to Dr. Jeffrey Millman.
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Postdoctoral Position
Post-Doctoral Fellowship positions in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical School. Two positions are available immediately for a period of 3 years each. For both positions applications are invited from individuals with a PhD or MD or MD PhD degrees. 1) The first position is for training in exciting projects focused on Metabolism such as defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology including inter-organ cross-talk in the overall maintenance of glucose homeostasis. The projects will utilize including induced pluripotent stem cells, genetically engineered and humanized mouse models. Topics are flexible - some examples include growth factor (e.g. insulin/IGF-1) signaling, mRNA modifications and stem cell biology. Candidates should have a strong background in molecular biology, cell biology (stem/iPS cells) and biochemistry. It is an advantage if candidates have the ability to interrogate “omics” and sequencing datasets. Candidates should possess skills or be willing to learn handling human islets, in vivo animal studies, rodent islet isolation and immunostaining. 2) For the second position candidates with expertise in Bioinformatics will be especially relevant. Prospective candidates should have expertise in handling large ‘omics’ databases and be willing to work closely with other Fellows in the lab to assist in analyses of biological data from diverse projects. Candidates will also be encouraged to develop their own research interests. Applicants for both positions should provide a brief statement of research interests, CV, and the names of three references to Dr. Kulkarni.
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Postdoctoral Position
The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope is looking for a talented postdoctoral fellow. The collaborative laboratories of Drs. John Kaddis and Bart Roep are jointly seeking innovative postdoctoral candidates to conduct in-silico translational research in the field of type 1 diabetes (T1D). This individual will participate in one or more projects that examine the role of molecular, cellular, genetic, and epidemiological variation in T1D. This candidate will have an opportunity to work with specialists in the fields of immunology, diabetes, and data/computer science. Expertize in statistical methods for disease risk prediction and modeling, as well as clinical data, genome sequence, SNP array, “-omics”, and large-scale genetic association analysis is helpful. Experience with public databases/repositories is highly desired. Necessary skills include those from bioinformatics, computer/data science, mathematics, software engineering, and computational biology. Please send your CV, cover letter, and contact information with 3 references to
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Postdoctoral Position
A postdoctoral position is available in the group of Dr. Remi Creusot at the Columbia Center for Translational Immunology (CCTI), to participate in research investigating the pathophysiology and therapy of autoimmune diabetes. The research will focus primarily on two NIH-funded projects: one studying the development and function of autoreactive T cells in humanized mouse models and a collaborative project on engineered stromal cells to reestablish immune tolerance. Applicants should send a full CV, a one-page cover letter highlighting research interests and goals, and the name and contact details of 3 references directly to Dr. Remi Creusot.
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively several projects including a multi-PI (MPI) NIH project " U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, " where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The main research focuses of the Nakai lab are: (1) AAV vector biology - capsid assembly, genome packaging, and virus-host interactions in rodents and non-human primates; (2) AAV antigen-antibody interactions; (3) developing novel vectors by engineering of AAV capsids; and (4) preclinical studies of gene therapy for the treatment of various human diseases including type I diabetes. Please send a cover letter and C.V. to Dr. Hiroyuki Nakai.
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