HIRN EMERGING LEADERS INVESTIGATORS |
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Please join us in welcoming the 5 recipients of the HIRN “Emerging Leaders in T1D” initiative. This funding opportunity was designed to provide support and protected time for senior postdoctoral fellows seeking to pursue studies that will enhance their transition toward independent research careers.
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Harvard University
Project: Measuring islet-wide Function with Soft Integrated Nanoelectronics
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University of California,
San Francisco
Project: Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells
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University of Colorado Denver
Project: Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets
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Children's Hospital of Philadelphia
Project: Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
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University of Florida
Project: The SIRP:CD47 Signaling
Pathway in Pancreatic b-Cell Survival
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HIRN now has a YouTube Channel. All of the publicly recorded videos from our Webinar & Tutorials will be posted on this channel to share with the research community. We encourage you to subscribe and to share an informational video you may have that you would like us to share profiling your HIRN research.
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RESEARCH/RESOURCE HIGHLIGHT |
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HIRN’s progress in machine learning (ML) can be highlighted through two excellent open-source software tools, immuneML and PennAI. The recent product of a large collaboration that includes the Brusko lab, immuneML brings a more reproducible, transparent, and interoperable machine learning framework to the study of adaptive immune receptor repertoires (AIRR). Functionally, immuneML supports the application of ML to get insights out of AIRR data as well as the development of new AIRR-tailored learning methods. This is demonstrated by example workflows to reproduce a previous repertoire classification analysis, do prediction with a new ML method, and perform benchmarking using synthetic data. The platform is currently available as a Python package, through a Galaxy web interface, and as a Docker image.
PennAI, previously published by the Moore lab, is another tool for machine learning that is not domain specific and accessible for non-experts. PennAI facilitates machine learning for non-experts by offering supervised learning with a validated recommender system to help select the best method and parameters given the input data and past results. It is implemented with a user-friendly no-code web interface; all components can be set up locally using Docker compose.
Resource papers:
Resource links:
About Research Highlight
This is a new section of the Monthly Newsletter for HIREC to help disseminate research and/or resources. Let us know if you would like to be featured.
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Office Hours: Next Session April 1, 2021
(On the first Thursday of every month from 2-3pm EST/11am-12pm PST).
Password: 123456
Dial: +1 415 762 9988 (US Toll)
Meeting ID: 955 4466 1617
Learn more about:
- HIRN Resources: How to enter a new resource or search existing resources
- How to get an RRID for a resource
- How to make your protocols more widely available on protocols.io *
- How to Dockerize your pipeline/application code *
- FAIR: Is your research FAIR? Get suggestions on your output
- How to make your data more FAIR by depositing in Zenodo *
- Social Media: Learn how to self-promote your research and/or lab
- And any other HIRN-related questions you may have!
Moderators:
Human Islet Research Enhancement Center (HIREC) at City of Hope:
-Layla Rouse, MS, HIRN Program Manager
-Anh Nguyet Vu, Scientific Data Coordinator
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100 YEAR INSULIN ANNIVERSARY |
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To celebrate the 100 year anniversary of the discovery of human insulin the University of Toronto is hosting a free virtual meeting on April 14-16, 2021. Additionally, they are sponsoring Trainee & Early Career Investigator Awards. Abstracts are due March 1. The Scientific Symposium will provide comprehensive updates on the latest advances in diabetes treatment and management through a series of online educational sessions and live, online, panel discussions with the experts. To register for this event please click HERE.
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THE WHO GLOBAL DIABETES COMPACT |
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On World Diabetes Day, WHO (World Health Organization) announced the development of
the Global Diabetes Compact, a comprehensive and inclusive approach to support countries in implementing effective programmes for the prevention and management of diabetes. The Compact will bring together in one package all WHO materials for the prevention and management of diabetes, both existing and new. The Compact will be launched in April 2021. Read more HERE.
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Date: May 15, 2021
Time: 9:00 am - 12:30 pm EST
This half-day program is designed for scientists/investigators, students and clinicians with an interest in diabetes. All are welcome, CMEs to be offered, no registration fee. Learn more HERE.
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dkNET Webinar
The dkNET (NIDDK Information Network) is inviting you to join them for a webinar "Multi-Omics Data Integration for Phenotype Prediction of Type-1 Diabetes" on Friday, April 9, 2021, 11 am - 12:00 pm PST. Omics techniques (e.g., i.e., transcriptomics, genomics, and epigenomics) report quantitative measures of more than tens of thousands of biological features and provide a more comprehensive molecular perspective of studied diabetes mechanisms compared to transitional approaches. Identifying representative molecular signatures from the tremendous number of biological features becomes a central problem in utilizing the data for clinical decision-making. Exploring the complex causal relations of the identified representative molecular signatures and diabetes phenotypes can be the most effective and efficient ways to improve the understanding of diabetes and assess the cause of diabetes for the new patients with already collected data influencing (e.g., TEDDY project). Presenter: Dr. Wei Zhang. Register HERE.
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Diabetes Research Centers Virtual Seminar Series
To address the disruption in seminars & scientific interactions at the onset of the Covid-19 pandemic, nine NIDDK-sponsored Diabetes Research Centers (DRCs) and three Centers for Diabetes Translational Research (CDTRs) established a weekly Virtual Seminar series. The series has been well-received and will continue. Anyone can register for the seminars, which are free and open to the public (registration required).
Speaker: Dr. William Parker, University of Chicago, Dr. Monica Peek, University of Chicago, Dr. Kamlesh Khunti, University of Leicester.
Date: April 14, 2021 at 1:00 pm CT.
Title: COVID-19 Panel: Spotlight on Healthcare Disparities, Diabetes Care, and Vaccine Distribution
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SUMMER STUDENT INTERNSHIP |
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dkNET Summer of Data Student Internship Program
The 2021 dkNET Summer of Data Student Internship program provides students an opportunity to utilize the dkNET tools and resources in a research project and to provide feedback on their experience to the dkNET team. Don't miss this great opportunity to learn best practices to enhance rigor and reproducibility and learn the basics of good data management by following the FAIR (Findable, Accessible, Interoperable, Reusable) data principles! The program is a 6-week online program, and selected students will receive $1,000 awards. Research projects should be in the areas of the NIDDK including diabetes, obesity, nutrition, digestive, kidney, liver, urologic, endocrine, metabolic, bone, and blood diseases. Preference will be given to those projects that would most benefit from the types of services offered by dkNET, e.g., projects that involve antibodies, genetically modified organisms, and ‘omics’ data. The program is designed for both bench and bioinformatics scientists. No programming skills are required. For more information please click HERE.
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RFA-RM-21-010: Cellular Senescence Network: Consortium Organization and Data Coordinating Center (U24 Clinical Trial Not Allowed)
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Application due date: March 22, 2021
- Foreign applications are allowed
RFA-RM-21-009: Cellular Senescence Network: Technology Development and Application (UG3/UH3 Clinical Trial Not Allowed)
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Application due date: March 22, 2021
- Foreign applications are allowed
RFA-RM-21-008: Cellular Senescence Network: Tissue Mapping Centers
(U54 – Clinical Trial Not Allowed)
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Application due date: March 22, 2021
- Foreign applications are allowed
RFA-DK-21-005: Immune Cell Engineering For Targeted Therapy And Disease Monitoring in Type 1 Diabetes (R01 Clinical Trial Not Allowed)
- Application due date: June 22, 2021
PAR-20-140: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
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Application due date: Standard dates apply
- Foreign applications are allowed
F31 PAR-19-378: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
F32 PAR-19-379: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
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Program Director for Diabetes Behavioral Science
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking a clinical behavioral scientist to serve as Program Director for Diabetes Behavioral Science. The Program Director will play an active role in stimulating new research and managing ongoing grant portfolios focused on understanding the interaction between behavioral, psychological, and biological factors to inform development of more effective and targeted interventions to prevent and treat diabetes. Apply Here
Program Director for Health Equity in diabetes
Program Officials
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring program officials with expertise in translational research involving stem cell biology, regenerative medicine and human pathophysiology as it relates to Diabetes, Endocrinology and Metabolic Diseases. The mission of the Division of Diabetes, Endocrinology and Metabolic Diseases is to support broad-based research programs focused on both basic and clinical research in the areas of type 1 and type 2 diabetes and other metabolic diseases, including cystic fibrosis; endocrinology and endocrine diseases; obesity, neuroendocrinology, and energy balance; and development, metabolism, and basic biology of liver, fat, and endocrine tissues. DEM also provides funding for the training and career development of individuals committed to academic and clinical research careers in these areas. Apply Here
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Research Scientist
The University of Chicago beta cell/diabetes research group under the direction of Dr. Raghu Mirmira has funded openings for several postdoctoral research scientists with interest in applying/learning cell biological techniques (immunoprecipitation, immunohistochemistry, confocal imaging), mouse genetic skills, human islet biology, and immunology and inflammation research. NIH-funded research projects in the Mirmira laboratory include the study of beta cell development and function, human islet gene regulation and mRNA translation, and islet cytokine signaling in the context of type 1 diabetes. Please send your CV, cover letter, and contact information with 3 references to Dr. Mirmira.
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Faculty Position
The Lilly Diabetes Center of Excellence (LDCE) at the Indiana Biosciences Research Institute (IBRI) is recruiting promising young investigators to start their own independent laboratories under excellent research conditions. The LDCE is recruiting high-potential Principal Investigators (PIs) at the IBRI in Indianapolis, Ind., who are interested in pancreatic beta cell research, particularly related to iPSC-derived beta cells and the crosstalk between beta cells and the immune system in type 1 diabetes (T1D). Please send your CV, cover letter, and contact information with 3 references to Dr. Eizirik.
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Faculty Position
The Diabetes Center of Excellence at the University of Massachusetts Medical School invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment. Please send your CV, cover letter, and contact information with 3 references to Dr. Harlan.
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Faculty Position
The Diabetes Clinical Research Program (DCRP) at Benaroya Research Institute at Virginia Mason (BRI) seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement. The DCRP is an international leader in type 1 (autoimmune) diabetes research. We are looking for an investigator with strong interest in clinical research and clinical trials to take a leadership role within the DCRP and work on national, regional, and local projects in type 1 diabetes. Experience in epidemiology, clinical investigation and/or clinical trials preferred; however, applicants with related research experience will be considered including work outside of type 1 diabetes. Requires an MD and a license to practice medicine in US. Please send your CV, cover letter, and contact information with 3 references HERE.
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Postdoctoral Position
Interested in small-molecule discovery and modulating beta-cell phenotypes? The Wagner lab in the Chemical Biology & Therapeutics Science (CBTS) Program at the Broad Institute, is accepting applications for postdoctoral fellow positions. We are looking for researchers interested in studying small molecule-mediated beta-cell survival. Candidates should have a strong record of productivity and publication in islet biology or chemical biology. Interested applicants should send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Wagner.
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Postdoctoral Position
The Montreal Diabetes Research Center at the University of Montreal, has two Postdoctoral positions available at the Rutter laboratory. The laboratory studies pancreatic beta cell biology and its perturbations in type 2 diabetes (Rutter et alDiabetologia, 63(10):1990-1998. doi: 10.1007/s00125-020-05205-5, 2020). The objectives of the two projects are to explore the role and regulation of interactions between beta cells within the pancreatic islet using live cell imaging and optogenetics (Project 1), and to understand how genomic variants associated with type 2 diabetes impact pancreatic beta cell function (Project 2). The successful applicants will hold a PhD or equivalent. Experience in islet biology and/or glucose homeostasis, calcium signaling and image analysis (Project 1) or CRISPR/Cas9 genome editing, culture of human-derived beta cells or directed differentiation of embryonic stem cells towards a beta cell fate would be advantageous. Candidates with experience in data analysis using R, MATLAB etc. are particularly welcome to apply. Please send a cover letter and curriculum vitae, including three references, to Dr. Rutter.
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Postdoctoral Position
A postdoctoral position is available in the Lab of Dr. Sangeeta Dhawan at the Beckman Research Institute at City of Hope, in Los Angeles county, CA to study pancreatic beta cell development and maturation. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable. The candidate should send a cover letter/statement of research interests, CV, and contact information for three references directly to Dr. Sangeeta Dhawan.
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Postdoctoral Position
The Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute is seeking creative and highly motivated individuals for the position of Postdoctoral Associate under the direction of Dr. Todd Brusko. The Postdoc will be engaged in studying novel pathways regulating the differentiation and pathogenicity of T cells, the function of regulatory T cell biology in autoimmunity. Please send your CV, cover letter, and contact information with 3 references to Dr. Brusko.
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Postdoctoral Position
The laboratory of Dr. Amelia Linnemann at the Indiana University Diabetes Center has an opening for a PhD and/or MD postdoctoral research scientist with skills in cell/molecular biological techniques (immunoprecipitation, western blotting, cloning) and/or microscopy. Research projects in the Linnemann laboratory include the study of pancreatic islet dysfunction and cytokine signaling in the context of type 1 and type 2 diabetes, with a focus on autophagy and the antioxidant response. Interested applicants are encouraged to send an updated CV and names of 3 references to Dr. Amelia Linnemann.
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Postdoctoral Position
Pacific Northwest National Laboratory has a postdoctoral position available to join their multi-disciplinary team focused on mass spectrometry (MS) based omics analyses. This project is part of the Human Islet Research Network funded by the National Institute of Health. We are investigating the roles of alternative splicing in beta cell stress and development of type 1 diabetes. Interested candidates please send your CV, cover letter, and contact information with 3 references to Dr. Nakayasu.
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Postdoctoral Position
The University of Florida under the Stabler laboratory is seeking a creative and dedicated postdoctoral associate to join their team in working on translational research in Type 1 diabetes. The research goals for this position are in the translation of our bioactive scaffolds and coatings into preclinical models for validation and optimization. As a highly collaborative laboratory, the Associate will integrate as a part of our team, working together with members of the laboratory, as well as our extensive researcher network. The Associate will be expected to take a leadership role in the laboratory, directing research goals and timelines, mentoring students, and writing reports and publications. Interested candidates should submit a CV, a summary of future research interests and goals, and three references to Dr. Cheri Stabler.
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Postdoctoral Position
A postdoctoral research associate position is available in the Hughes Lab at the Washington University School of Medicine to study primary cilia in islet cells. The laboratory combines standard molecular and cell biology with advanced imaging techniques to explore novel roles of cilia in mouse and human islets. We have generated new cilia knockout mouse models with strong diabetic phenotypes and are looking for someone to lead the investigation of cilia-mediated signaling mechanisms in islet hormone secretion. For human studies, we have a funded project to image primary cilia in T1D pancreas which will generate important and clinically relevant findings in autoimmune diabetes. Interested candidates please email Dr. Jing Hughes. Please send your CV, cover letter, and contact information with 3 references to Dr. Hughes.
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Postdoctoral Position
Postdoctoral Scholar Positions in Microphysiological Systems (“Tissue Chips”) in the Hughes Lab. An NIH-funded postdoctoral position is available to work on the development of body-on-chip devices in the areas of pancreatic islets (Type 1 diabetes). The ideal candidate will have experience in cell culture, vascular biology, bioengineering (including COMSOL modeling), and microfluidic systems. Prior knowledge in the areas of diabetes would be an advantage, however, candidates with any combination of the above should consider applying. Please send your CV, cover letter, and contact information with 3 references to Dr. Hughes.
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Postdoctoral Position
The Arrojo e Drigo lab focuses on the mechanisms regulating post‐mitotic cell homeostasis and longevity. Many postmitotic cells can be as old as the organism, which makes them remarkably long‐lived. We study long‐lived cells in different organs and explore their developmental trajectory, structure‐function and aging patterns. Our lab uses a combination of single cell sequencing and high‐resolution light, electron and isotope microscopy platforms to overlay cell structure‐function with molecular identity, age and metabolism. Applications are invited for a postdoctoral position to study the physiology of long‐lived cells in the pancreas. Please send your CV, cover letter, and contact information with 3 references to Dr. Arrojo e Drigo.
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Postdoctoral Position
The Voight lab invites applications for a computational Post-Doctoral position at the University of Pennsylvania School of Medicine, within the Department of Systems Pharmacology and Translational Therapeutics and the Department of Genetics. The lab focuses on translating discoveries from human genetics data into insights about the biological basis and genetic architecture of human disease (ultimately toward developing new therapeutics targets for human disease), and understanding selection
during recent human evolution. The candidate will have a MD, PhD, or equivalent doctorate, with a strong background in one or more of the following areas: statistics, biostatistics, population genetics, human genetics, genetic epidemiology, computational biology and/or genomics, bioinformatics. Please send your CV, cover letter, and contact information with 3 references to Dr. Voight.
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Postdoctoral Fellows
The Powers & Brissova research group in the Vanderbilt Diabetes Center is seeking a postdoctoral fellows to study human pancreas and islet biology with a focus on gene expression and developmental biology of single cells. We are especially interested individuals with computational or informatics
expertise, multimodal, multiplex imaging experience, or live cell imaging experience. Please send your CV, cover letter, and contact information with 3 references to Dr. Powers.
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Two Postdoctoral positions in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical School. For the first position, applications are invited for prospective Post-Doctoral Fellows to train in the Kulkarni Lab. The two positions are available immediately for a period of 2 years with the possibility of extending for a third year based on available funds and performance. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in exciting projects focused on defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis using induced pluripotent stem cells and animal models. Successful candidates should have a strong background in molecular biology, cell biology (stem cells) and biochemistry. It is strongly preferable to have prior experience in bioinformatics and the ability to interrogate “omics” and sequencing datasets. Prospective candidates should possess skills in handling human islets and undertake animal studies. It would be an advantage to be able to undertake rodent islet isolation, and perform immunostaining. For the second position candidates with expertise in bioinformatics will be especially relevant. Prospective candidates should have expertise in handling large ‘omics’ databases and be willing to work closely with other Fellows in the lab to assist in analyses of biological data from multiple projects. Candidates will also be encouraged to develop their own research interests. Applicants for both positions should provide a brief statement of research interests, CV, and the names of three references to Dr. Kulkarni.
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Postdoctoral Associate
The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. Please send your CV, cover letter, and contact information with 3 references to Dr. Millman.
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Postdoctoral Associate
Rutgers, the State University of New Jersey, is seeking a Research Associate for the Child Health Institute of New Jersey. The position is available in El Ouaamari’s laboratory to investigate the role of the peripheral neurons in the regulation of systemic energy homeostasis in the context of obesity and diabetes. Self-driven, creative, resourceful and independent candidates with a PhD in neuroscience or neurobiology are encouraged to apply. Prior postdoctoral experience in neuroscience or related fields is required. Please send your CV, cover letter, and contact information with 3 references to Dr. El Ouaamari.
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Postdoctoral Associate
The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Cellular definition and stability of CD8 T cell exhaustion associated with response to therapy, and 3) identification of biomarkers of disease severity. The Postdoctoral Research Associate conducts independent biomedical research relevant to defining mechanisms underlying CD8 T cell exhaustion in the context of type 1 diabetes (T1D). The Postdoctoral Research Associate is a team-player who welcomes challenges and wants to grow as a translational biologist. Requires a Ph.D. in Immunology or a related field and experience in tissue culture, cellular and molecular techniques. Please send your CV, cover letter, and contact information with 3 references to Dr. Long.
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project ” U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, ” where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The successful candidate will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff. Please send a cover letter and C.V. to
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Research Associate II
The Arrojo e Drigo laboratory at Vanderbilt University, has a research assistant II position open. This position requires knowledge of laboratory procedures, record keeping, validated experience in animal handling and anatomy, animal colony management, and standard molecular biology procedures. The research assistant II will support ongoing experiments in animal procedures, molecular biology, cell culture and microscopy. Motivated individuals will have their own projects and perform animal-related research. Additional responsibilities will include maintenance of and management of transgenic animal colonies and genotyping. Please send your CV, cover letter, and contact information with 3 references to
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Program Manager
The University of Pennsylvania has a opening for a Program Manager under the direction of Dr. Kaestner. The Program Manager will be in charge of coordinating with other Core functions within HPAP, such as the organ procurement and islet isolation core as well as the data analysis core. The Program manager will directly supervise two research specialists who have been trained in the biochemical and molecular biology assays required by HPAP. In addition, the program manager will collaborate with Dr. Kaestner in directing all scientific projects that arise from the program, and also attend all HPAP group meetings as well as relevant scientific conferences. Master's Degree with 3-5 years of related experience in research, clinical study, project and people management or equivalent combination of education and experience is required - Ph.D. preferred. Please send your CV, cover letter, and contact information with 3 references to Dr. Kaestner.
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dkNET Community Liaison
The NIDDK Information Network has an open position for a Community Liaison to provide community outreach and lead engagement with the scientific community. This position will support a range of activities linked to community-dkNET partnerships, researcher engagement and knowledge networking. The position will entail engaging with research scientists, students and trainees, government, industry and broader audiences through workshops, in-person outreach events, multimedia, social media and Web-based systems. dkNET was launched by the FAIR Data Informatics Laboratory at the University of California, San Diego to serve the needs of basic and clinical investigators in diabetes, digestive and kidney disease by addressing the challenge of connecting researchers to research resources, assisting researchers with rigor and reproducibility guidelines, supporting researchers in navigating new data sharing requirements, and providing tools in enabling data discovery and hypothesis generation. More information click HERE.
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Research Technician
A new Stem Cell and Genome Editing Core Facility situated within the Kieffer Research Group has an opportunity for a highly motivated and collaborative technician to support diverse regenerative medicine research initiatives. The candidate will assist with the day to-day operation of the Core, will generate human induced pluripotent cells (iPSCs), and will culture and differentiate human embryonic stem cells (ESCs) and iPSCs down pancreatic lineages. Please send your CV, cover letter, and contact information with 3 references to Dr. Kiefer.
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