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HaemInsights

Issue 4 | August 2025

This edition looks at a blood film from a patient with sickle cell anaemia, displaying abnormal red cells, anisocytosis and polynuclear neutrophils.

Morphology Case Study

Abnormal red cells, anisocytosis and polynuclear neutrophils can all be seen in the morphology of this sickle cell anaemia patient.

Age & EDTA Effect on Full Blood Count Samples

Quiz

​

What is the best course of action when seeing numerous

features in the tail of a smear with the following results?

• WBC 8.60 (10^3/mm3)
• MCH 29.6 (pg)
• RBC 3.21 (10^6/mm3)
• MCHC 32.6 (g/dL)
• HGB 9.5 (g/dL)
• PLT 222* (10^3/mm3)
• HCT 29.1 (%)
• RDWsd 40.3 (fL)
• MCV 90.7 (fL)
• RDWcv 12.3 (%)

a) Ignore the features as they are in the tail of the smear.

b) Manually check the sample for clots. Comment on the fact that the platelet count may be underestimated and request a repeat.

c) Query if Microfilaria is present.

The answer will be revealed in the next HaemInsights newsletter and on our social media channels (LinkedIn and X).

Last Issue's Quiz Answer

Name the cell and what may it indicate?

The Answer:

The cell shown is known as a Band cell or Stab cell; if numerous are present in the blood smear, it is an indicator of infection or inflammation. Gross red cells abnormalities with large platelets and platelet clumps in a Beta Thalassaemia patient. Platelet production and their function in haemostasis and infection.

Editorial Team:

Kelly Duffy, Andrew Fisher, HORIBA UK Limited

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