‘Parkinson’s is a
man-made disease’
Europe’s flawed oversight of pesticides may be fueling a silent epidemic, warns Dutch neurologist Bas Bloem. His fight for reform pits him against industry, regulators — and time.
Text and photos
by BARTOSZ BRZEZIŃSKI
in Nijmegen, Netherlands
In the summer of 1982, seven heroin users were admitted to a California hospital paralyzed and mute. They were in their 20s, otherwise healthy — until a synthetic drug they had manufactured in makeshift labs left them frozen inside their own bodies. Doctors quickly discovered the cause: MPTP, a neurotoxic contaminant that had destroyed a small but critical part of the brain, the substantia nigra, which controls movement.
The patients had developed symptoms of late-stage Parkinson’s, almost overnight.
The cases shocked neurologists. Until then, Parkinson’s was thought to be a disease of aging, its origins slow and mysterious. But here was proof that a single chemical could reproduce the same devastating outcome. And more disturbing still: MPTP turned out to be chemically similar to paraquat, a widely used weedkiller that, for decades, had been sprayed on farms across the United States and Europe.
“Parkinson’s is a man-made disease,” he says. “And the tragedy is that we’re not even trying to prevent it.”
When the English surgeon James Parkinson first described the “shaking palsy” in 1817, it was considered a medical curiosity — a rare affliction of aging men. Two centuries later, Parkinson’s disease has more than doubled globally over the past 20 years, and is expected to double again in the next 20. It is now one of the fastest-growing neurological disorders in the world, outpacing stroke and multiple sclerosis. The disease causes the progressive death of dopamine-producing neurons and gradually robs people of movement, speech and, eventually, cognition. There is no cure.
Age and genetic predisposition play a role. But Bloem and the wider neurological community contend that those two factors alone cannot explain the steep rise in cases. In a 2024 paper co-authored with U.S. neurologist Ray Dorsey, Bloem wrote that Parkinson’s is “predominantly an environmental disease” — a condition shaped less by genetics and more by prolonged exposure to toxicants like air pollution, industrial solvents and, above all, pesticides.
Most of the patients who pass through Bloem’s clinic aren’t farmers themselves, but many live in rural areas where pesticide use is widespread. Over time, he began to notice a pattern: Parkinson’s seemed to crop up more often in regions dominated by intensive agriculture.
“Parkinson’s was a very rare disease until the early 20th century,” Bloem says. “Then with the agricultural revolution, chemical revolution, and the explosion of pesticide use, rates started to climb.”
Among the chemicals still in use, none has drawn more scrutiny — or survived more court battles — than glyphosate.
It’s the most widely used herbicide on the planet. You can find traces of it in farmland, forests, rivers, raindrops and even in tree canopies deep inside Europe’s nature reserves. It’s in household dust, animal feed, supermarket produce. In one U.S. study, it showed up in 80 percent of urine samples taken from the general public.
For years, glyphosate, sold under the Roundup brand, has been at the center of an international legal and regulatory storm. In the United States, Bayer — which acquired Monsanto, Roundup’s original maker — has paid out more than $10 billion to settle lawsuits linking glyphosate to non-Hodgkin’s lymphoma.
Unlike paraquat, which causes immediate oxidative stress and has been associated with Parkinson’s in both lab and epidemiological studies, glyphosate’s potential harms are more indirect — operating through inflammation, microbiome disruption or mitochondrial dysfunction, all mechanisms known to contribute to the death of dopamine-producing neurons. But this makes them harder to detect in traditional toxicology tests, and easier to dismiss.
The regulatory tests also isolate individual chemicals, rarely examining how they interact in the real world. But a 2020 study in Japan showed how dangerous that assumption may be. When rodents were exposed to glyphosate and MPTP — the very compound that mimicked Parkinson’s in the California heroin cases — the combination caused dramatically more brain cell loss than either substance alone.
Internal company documents released in court suggest Syngenta knew for decades that paraquat could harm the brain — a charge the company denies, insisting there is no proven link.
Evidence from the field is becoming harder to ignore. In France, a nationwide study found that Parkinson’s rates were significantly higher in vineyard regions that rely heavily on fungicides. Another study found that areas with higher agricultural pesticide use — often measured by regional spending — tend to have higher rates of Parkinson’s, suggesting a dose-response relationship. In Canada and the U.S., maps of Parkinson’s clusters track closely with areas of intensive agriculture.
In fact, early signs are already emerging. The Netherlands, known for having one of the highest pesticide use rates in Europe, has seen a 30 percent rise in Parkinson’s cases over the past decade — a slower increase than in some other regions of the world, but still notable, Bloem says. In farming regions like the Betuwe, on the lower reaches of the Rhine River, physiotherapists have reported striking local clusters. One village near Arnhem counted over a dozen cases.
Click here for full article
Click here for more info on Glyphosate and sign petition to ban
| 
