Prospects for ALS -
The View at Year's End - 2021
Remarkably, today we say farewell to 2021; this is an appropriate time to look back on recent developments in ALS research. It can truly be said that there has been meaningful progress in the quest to find treatments for ALS. Much has been accomplished in understanding the basic biology of this disease.
In the Angel Fund ALS research program, new methods of gene analysis are defining critical events that trigger motor neuron pathology, both in mouse models of ALS and in humans. At multiple laboratories, including those at UMass Chan Medical School (UMCMS), fresh insights into the role of non-neuronal cells have emerged, implicating specific pathways of inflammation in the brain and spinal cord.
A consortium of investigators, including the UMCMS team, has conducted a study of nearly 30,000 ALS cases and more then 120,000 controls that identified multiple new genetic risk factors for ALS. The search for biomarkers that indicate ALS disease activity has also advanced across multiple centers this year.
At UMCMS, investigators funded by the Angel Fund, have developed a new type of physiological biomarker for motor neurons that we anticipate could have wide application