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Crystal Watson, Tara Kirk Sell, Matthew Watson, Caitlin Rivers, Christopher Hurtado, Matthew Shearer, Ashley Geleta, Thomas Inglesby

 

This report highlights 15 technologies or categories of technologies that, with further scientific attention and investment, as well as attention to accompanying legal, regulatory, ethical, policy, and operational issues, could help make the world better prepared and equipped to prevent future infectious disease outbreaks from becoming catastrophic events Read now

Today's Headlines: October 9, 2018

Biological Agents & Infectious Diseases

DRC Records 12 New Ebola Cases Over the Weekend ( CIDRAP) The Democratic Republic of the Congo (DRC), in updates released Oct 5 through yesterday, detailed 12 new cases of Ebola in North Kivu province.  All but 2 of the cases were reported in Beni, the epicenter of the current outbreak. There are now a total of 177 cases (142 confirmed and 35 probable), including 113 deaths. Eleven suspected cases are under investigation. Go to article

Monkeypox and Hepatitis E Outbreaks Reported in the Central African Republic ( Outbreak News Today) The Ministry of Health and Population in the Central African Republic declared a new outbreak of monkeypox in Mbaiki health district, located in the south-western part of the country at the beginning of the month. Go to article

Zika Virus Resurfaces in India for the Third Time in Two Years ( QZ) A Zika outbreak has been reported in India, the third time in less than two years. In the past few weeks, the virus has been detected in 22 people in Jaipur, capital of the western state of Rajasthan. Go to article


Medicine & Public Health

Simple Estimates for Local Prevalence of Latent Tuberculosis Infection, United States, 2011-2015 ( Emerging Infectious Diseases) Approximately 25% of the world's population is latently infected with Mycobacterium tuberculosis. Latent tuberculosis infection (LTBI) is an asymptomatic equilibrium between the immune response of the host and the infectious process. Go to article

Pioneering CJD Treatment to Be Used on British Patient ( BBC News) Doctors have been given permission to give a British man with CJD a pioneering treatment, in a world first. There is currently no treatment for the rare but lethal brain disease, known as the human version of "mad cow disease". Go to article


Science & Technology

New Vaccine Technologies to Combat Outbreak Situations ( Frontiers in Immunology) Ever since the development of the first vaccine more than 200 years ago, vaccinations have greatly decreased the burden of infectious diseases worldwide, famously leading to the eradication of small pox and allowing the restriction of diseases such as polio, tetanus, diphtheria, and measles. Go to article

Critical Role for Cholesterol in Lassa Fever Virus Entry Identified by a Novel Small Molecule Inhibitor Targeting the Viral Receptor LAMP1 ( PLOS Pathogens) Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor of LASV and used it to analyze the mechanism of entry. Go to article

Small RNA-Based Antimicrobial Immunity ( Nature Reviews Immunology) Protection against microbial infection in eukaryotes is provided by diverse cellular and molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus-derived small interfering RNAs in fungi, plants, invertebrates and mammals, detailing the mechanisms for their production, amplification and activity. Go to article

Comprehensive Identification of Peptides in Tandem Mass Spectra Using an Efficient Open Search Engine ( Nature Biotechnology) We present a sequence-tag-based search engine, Open-pFind, to identify peptides in an ultra-large search space that includes coeluting peptides, unexpected modifications and digestions. Our method detects peptides with higher precision and speed than seven other search engines. Go to article

Emergent Closes on Deal to Acquire PaxVax ( Homeland Preparedness News) Emergent BioSolutions completed its acquisition of PaxVax, a company that develops specialty vaccines that protect against infectious diseases typhoid and cholera. Emergent now has two PaxVax vaccines -- Vivotif, which treats typhoid fever, and Vaxchora, which treats cholera. Go to article

Genetic Disease Healed Using Genome Editing ( EurekAlert!) Parents of newborns may be familiar with the metabolic disorder phenylketonuria: in Switzerland, all newborn babies are screened for this genetic disease. If a baby is found to have phenylketonuria, it needs a special diet so that the amino acid phenylalanine does not accumulate in the body. Go to article


Other 21st Century Threats

Second Skripal Poisoning Suspect Identified as GRU Doctor ( The Guardian) The investigative website Bellingcat has identified the second suspect responsible for poisoning Sergei Skripal as Alexander Mishkin, a doctor working for Russia's GRU military spy agency. The website said it had tracked down Mishkin's real identity after obtaining a scanned copy of his actual passport. Go to article


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Preparedness Pulsepoints: October 9, 2018
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Delivered first thing each Tuesday morning, Preparedness Pulsepoints provides a snapshot of each week's USG action on readiness and response. Read| Subscribe


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