Wishing you a joyful holiday season & a happy new year!

2020 has been a wonderful year for The North American 3Rs Collaborative. We hope you have also found some positive areas despite these challenging times. This will be our final newsletter of 2020 though we look forward to all that is to come in 2021. Check out our newest 3Rs resources and forward to a friend and tell them to subscribe!
HEALTH MONITORING

Does your institution still use soiled bedding sentinels for rodent health monitoring? Research supports environmental monitoring as a replacement that can even improve pathogen detection. Based on our most recent webinar, we've created a resource page for you to learn more.

COMPASSION FATIGUE

Our popular resource page on compassion fatigue has been updated! In October, two new peer-reviewed papers were published on the subject. We've added their conclusions (including new suggestions for helping compassion fatigue) to our page. Check it out!

ALTASCIENCES

Altasciences is NA3RsC's newest gold level supporter ($10,000+ donation). We would like to share what they are doing to implement the 3Rs & improve animal welfare. Scroll down to read the full story or watch their video on animal welfare.

DEVICE GRANT

The Sensory SentinelTM (Turner Scientific) is an environmental monitoring device recording noise, vibration, temp, humidity, & light levels every second, in animal rooms and individual cages. This can improve animal welfare and research outcomes. Turner Scientific is awarding 1 device through a competitive grant. All can apply (facility managers, scientists, grad/post-doc students, research vets, etc.) Deadline is Jan 4, 2021.

INNOVATIVATION IN DRUG DEVELOPMENT

Are you working on microphsyiological systems to assess safety or efficacy questions? The FDA has a pilot program to expand these and other tools with the potential to facilitate drug development. Read more in their recent announcement.

MICROSAMPLING

NC3Rs has launched a survey on the current use of microsampling. If you use microsampling within any research or safety study for new drugs and (agro)chemicals, they want to learn about the 3Rs impacts you have achieved. If you do not use microsampling, they want to know your concerns and any barriers you have experienced to help guide our future strategy. Survey closes Fri, Jan 22.

3-MIN 3Rs PODCAST

Want to learn about the latest 3Rs research, but don't have much time? Listen to 3-Minute 3Rs where we share 3 new articles in just 3 minutes! In December we cover protective cranial implant caps for macaques, a cage climber refinement for mice, and skin swabbing versus fin clipping for zebrafish. Produced by Lab Animal in with NC3Rs.

LAB ANIMAL SCIENCE VIRTUAL CONFERENCE

Mark your calendars for Feb 10, 2021. Join us, NJABR, and LabRoots for the Lab Animal Science Virtual Conference. This year's theme is From Theory to Practice, Tools & Considerations for Implementing the 3Rs. to increase understanding of 3Rs concepts and provide practical examples for implementation.

Guest article from Altasciences. Highlighting the 3Rs, & Animal Welfare

Altasciences’ role in the drug development process includes working with animals and understanding how they are crucial to advancing human and animal medical practices. This role comes with the significant responsibility of ensuring the welfare of research animals, a responsibility that Altasciences takes extremely seriously.

Adherence to the 3Rs philosophy should be the cornerstone of every Animal Welfare program. At Altasciences, we emphasize that welfare is about more than the animal you see in front of you. Making welfare-based decisions is also about the animals you don’t see, and an optimal 3Rs program encompasses both aspects.

Altasciences has built a well-designed, comprehensive, consistently-applied, animal welfare program. Early and transparent 3Rs communication with our sponsors is the first step in the success of our animal welfare program, and all departments continue to work with our clients throughout the study to ensure we capitalize on every opportunity to exceed 3R standards. Although we cannot eliminate the use of animals in our search for life-saving therapies, Altasciences is committed to doing everything possible to minimize the number of animals used and to ensure that the research animals in our care are treated with dignity and the utmost respect.

We are never complacent and have implemented a process in which our onsite Animal Welfare Officer reviews and improves our program on an ongoing basis. Every study is assigned a scientific expert – ensuring appropriate species selection and enhancing overall study design to maximize information gained from each animal. Study designs and programs are reviewed to ensure we use the minimum number of animals required to meet regulatory requirements for safety testing. Study designs include considerations for socialization, enrichment, and caging type. Altasciences’ on-site behaviorist evaluates the temperament and behavioral profile of each research animal to guide in animal selection for study. Research animals are acclimated to all handling procedures prior to start of study and positive reinforcement is used after all potentially stressful events for all species.

After study completion, whenever possible, our research animals may become part of our animal adoption program, be transferred to our onsite training colony, be placed onto other appropriate studies if scientifically feasible, or even be transferred to external breeding colonies.

Although eliminating the use of animals in the search for life-saving therapies is not yet possible, Altasciences is committed to doing everything possible to minimize the number of animals used and to ensure that the animals used are treated with care, dignity, and the utmost respect.

All aspects of an animal research program play a role in maintaining an exceptional animal welfare program – from animal procurement to study implementation to animal disposition to study reporting.  As part of our mission to support the drug development process, we respect the value of life (for all living creatures) and the immense contribution animals make towards the medical advancements for all of us, our families, our pets, and those in our communities. We honor the ethical and moral obligations we are given as a result of this responsibility. Altasciences considers the humane and appropriate care of all animals a high priority. We have been vigilant in building a solid team of professionals to care for and support the animals at our facilities, at all times, and recognize that the success of our welfare program relies upon staff at every level making a commitment to drive the program forward. At Altasciences, we acknowledge that it may be the animals we never see that are the most important measure of our success!

As you can see, NA3RsC is working hard to advance the science and education of refining, reducing, and replacing animals in laboratory research. Your donation to the North American 3Rs Collaborative will enable us to expand these efforts.

We are grateful to our current sponsors for supporting our 3Rs efforts.

Below are our gold level sponsors. See all sponsor levels on our website.