This study supports further investigation into how epigenetic changes work to silence the paternal UBE3A gene. Targeting multiple mechanisms that underlie paternal UBE3A silencing could result in the increased and persistent UBE3A protein levels equivalent to that in typical neurons. 

Essentially, this helps us identify another target for a therapeutic approach under Pillar 2 of our Roadmap to a Cure and the better understanding we have of the paternal gene helps us understand how to unsilence it.

Read the article:

The Cure Angelman Now (CAN) campaign is an annual fundraising effort led by parents, family and friends of individuals living with Angelman syndrome to help raise funds to support and advance critical research toward our mission of curing Angelman syndrome. Earlier this month, our top 2023 CAN fundraisers were invited to Texas A&M University where they toured the lab of Dr. Scott Dindot to see the impact of their generosity in action.

Read more about the 2023 CAN Grand Prize trip:

A friendly reminder that the 17th Annual Global Science Summit and Gala will be held on November 8-9, 2024 in Orlando, Florida.

💸 Scholarship Application opens June 3

🗓️ Registration opens August 1 

🌎 If you live outside of the United States and will need a visa to travel to the US, please consider applying now. If you would like FAST to write you a letter of invitation for you to enclose with your visa application, we are happy to do so. To request a letter of invitation, please email events@cureangelman.org and provide the full names of the people in your family who will attend.

More information:

For the 6th time, we are excited to partner with a generous breeder from Pennsylvania who is graciously donating a puppy to a deserving FAST family. An adorable standard poodle is looking for a loving home! 

Submit an application with a photo of your family and child that lives with Angelman syndrome and share why this dog will impact your life. 

Enter the giveaway here:

Disclaimer: Selection of puppy placement will be made strictly by the breeder, not FAST. If selected, the owner must be able to travel to Pennsylvania to pick up the puppy. Puppy does not come as a trained service animal but is screened to be a therapy dog. Training would be the responsibility of the owner.

People with disabilities rely on Medicaid home and community-based services (HCBS) to live independently in their communities. HCBS helps people with disabilities with everyday support, like getting around the community, employment support, dressing, bathing, taking medication, and much more!

However, due to the fact that Medicaid must fund institutions, and home and community-based services are optional, states don't have the funding to support everyone in the community. This means that:

• Over 650,000 people are stuck on waiting lists
• Direct care workers are underpaid due to stagnant wages
• Too often unpaid family caregivers are filling in the gaps in service – it’s a crisis!
• We need Congress to take action NOW.

Tell your members of Congress to support the HCBS Relief Act, which will mandate these supports and services in Medicaid — because #CareCantWait!

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