JANUARY 21, 2021


Recent high-impact publications from Rogel Cancer Center members.
Interdisciplinary collaborations between Basic Sciences, Cancer Control & Population Sciences, and Translational & Clinical Research members
Chung, C.; Sweha, S. R.; Pratt, D.; Tamrazi, B.; Panwalkar, P.; Banda, A.; Bayliss, J.; Hawes, D.; Yang, F.; Lee, H. J.; Shan, M.; Cieslik, M.; Qin, T.; Werner, C. K.; Wahl, D. R.; Lyssiotis, C. A.; Bian, Z.; Shotwell, J. B.; Yadav, V. N.; Koschmann, C.; Chinnaiyan, A. M.; Bluml, S.; Judkins, A. R.; Venneti, S. Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas. Cancer Cell (2020) PMID: 32795401. PMCID: PMC7494613.

Zhou, W.; Yao, Y.; Scott, A. J.; Wilder-Romans, K.; Dresser, J. J.; Werner, C. K.; Sun, H.; Pratt, D.; Sajjakulnukit, P.; Zhao, S. G.; Davis, M.; Nelson, B. S.; Halbrook, C. J.; Zhang, L.; Gatto, F.; Umemura, Y.; Walker, A. K.; Kachman, M.; Sarkaria, J. N.; Xiong, J.; Morgan, M. A.; Rehemtualla, A.; Castro, M. G.; Lowenstein, P.; Chandrasekaran, S.; Lawrence, T. S.; Lyssiotis, C. A.; Wahl, D. R. Purine Metabolism Regulates DNA Repair and Therapy Resistance in Glioblastoma. Nat Commun (2020) PMID: 32732914. PMCID: PMC7393131.
Mehta, R. K.; Pal, S.; Kondapi, K.; Sitto, M.; Dewar, C.; Devasia, T.; Schipper, M. J.; Thomas, D. G.; Basrur, V.; Pai, M. P.; Morishima, Y.; Osawa, Y.; Pratt, W. B.; Lawrence, T. S.; Nyati, M. K. Low Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts. Clin Cancer Res (2020) PMID: 32718999. PMCID: PMC7541797.
Salami, S. S.; Tosoian, J. J.; Nallandhighal, S.; Jones, T. A. Jr; Brockman, S.; Elkhoury, F. F.; Bazzi, S.; Plouffe, K. R.; Siddiqui, J.; Liu, C. J.; Kunju, L. P.; Morgan, T. M.; Natarajan, S.; Boonstra, P. S.; Sumida, L.; Tomlins, S. A.; Udager, A. M.; Sisk, A. E. Jr; Marks, L. S.; Palapattu, G. S. Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study. Eur Urol (2020) PMID: 32631746.
Experimental drugs designed to reduce the body’s natural production of alpha-ketoglutarate slow tumor growth and increase lifespan in mouse models of DIPG.

Jagsi, R.; Griffith, K. A.; Vicini, F.; Boike, T.; Burmeister, J.; Dominello, M. M.; Grills, I.; Hayman, J. A.; Moran, J. M.; Paximadis, P.; Radawski, J. D.; Walker, E. M.; Pierce, L. J. Toward Improving Patients' Experiences of Acute Toxicity From Breast Radiotherapy: Insights From the Analysis of Patient-Reported Outcomes in a Large Multicenter Cohort. J Clin Oncol (2020) PMID: 32986529.

Demirci, H.; Elner, V. M.; Demirci, F. Y.; Robinson, D. R.; Chinnaiyan, A.; Schlachter, D.; Joseph, S.; Worden, F. Immunotherapy for Conjunctival Squamous Cell Carcinoma with Orbital Extension. Ophthalmology (2020) PMID: 32980395.

Tosoian, J. J.; Feldman, A. S.; Abbott, M. R.; Mehra, R.; Tiemeny, P.; Wolf, J. S. Jr; Stone, S.; Wu, S.; Daignault-Newton, S.; Taylor, J. M. G.; Wu, C. L.; Morgan, T. M. Biopsy Cell Cycle Proliferation Score Predicts Adverse Surgical Pathology in Localized Renal Cell Carcinoma. Eur Urol (2020) PMID: 32943262.

Jalihal, A. P.; Pitchiaya, S.; Xiao, L.; Bawa, P.; Jiang, X.; Bedi, K.; Parolia, A.; Cieslik, M.; Ljungman, M.; Chinnaiyan, A. M.; Walter, N. G. Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change. Mol Cell (2020) PMID: 32857953. PMCID: PMC7502480.
A new observational study indicates that for patients undergoing breast radiotherapy, the experience of pain may be associated with numerous factors. Findings of the study were reported in the Journal of Clinical Oncology.

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