August 2016

Dear Colleagues,

Sanford Burnham Prebys Medical Discovery Institute honors the memory of Conrad Prebys and Pauline Foster who passed away last month. They were good friends and strong supporters of the Institute’s biomedical research and we will miss them.

One way to honor them is to recognize the important science that their contributions supported.

The August issue of Discoveries shares some of the biomedical research that their generosity enabled.


We honor Conrad Prebys

Conrad Prebys, an honorary trustee and namesake of our Institute, passed away on July 24th. Prebys believed in giving back and sharing his success with others. The staff, scientists and leadership of Sanford Burnham Prebys Medical Discovery Institute (SBP) are grateful for his confidence in our research and honored to be a recipient of his generosity.

Read more on Beaker >>

Select media coverage: San Diego Union-Tribune

Remembering Pauline Foster, trustee and community leader
Kristiina Vuori & Pauline Foster
A supporter of SBP for the past 10 years, Pauline Foster served as a trustee and governance committee member beginning in 2010. Her major gift that year established the Pauline and Stanley Foster Presidential Chair, held by Kristiina Vuori, M.D., Ph.D., president of SBP.

Select media coverage: San Diego Union-Tribune
Science News
Scientists discover potential avenue to early treatment for type 2 diabetes

Researchers in the laboratory of Daniel P. Kelly, M.D., have identified a new potential target for drugs to prevent type 2 diabetes. Their paper in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor called MondoA in muscle helps reverse insulin resistance.

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Select media coverage: Yahoo! Finance, ScienceDaily

Breakthrough in understanding how stem cells become specialized

How do the cells of an organism, which all contain the same genetic information, come to be so diverse? New research from Laszlo Nagy, M.D., Ph.D., and his team, published in Molecular Cell, helped answer this question by finding a protein called OCT4 that restricts the range of cell types that stem cells can become.

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Select media coverage: ScienceDaily

Genetic drivers of immune response to cancer found through 'big data'

"To develop immunotherapies for a wide range of cancers, we need to know a lot more about how the immune system interacts with tumors," according to Adam Godzik, Ph.D. He and a postdoc analyzed genomic data from thousands of tumors to identify over 100 new relevant genetic regions, published in Cancer Immunology Research.

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Select media coverage: FierceBiotech, ScienceDaily

Possible target to stop cancer stem cells

Cancer stem cells can divide indefinitely—killing them could stop a tumor from growing or ever coming back. Researchers in the lab of Dieter Wolf, M.D., have found a new possible target for therapies that do exactly that. Their paper in Cell Reports shows that blocking eIF3d and eIF3e prevents the production of proteins that cancer stem cells use to generate energy.     

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Turning kids on to science
Graduate student Marisa Sanchez gets kids hooked on science

"After the first week, I was hooked!" Through hands-on lessons, Marisa, an SBP graduate student, helped kids see the scientific principles that govern our world, and how understanding those rules can be applied to do fun things.
Summer program sparks Preuss high schoolers' passion for research

A program for rising juniors at The Preuss School, which serves low-income students, shows them that lab life can be fun. The program exposes them to a range of opportunities that scientific training opens up.
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Epstein Family Foundation gives $1M for pancreatic and prostate cancer research
The gift, contributed by SBP board member Dan Epstein and his wife, Phyllis, will support the lab of Nicholas Cosford, Ph.D., who is developing medicines that block the pathways tumor cells use to survive.  

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Select media coverage: Times of San Diego
Welcome to our newest and recently renewed President's Circle Members!
• Nina Fishman and Alan Attridge
• Lucille Miller
• Peggy and Peter Preuss
• Qualcomm, Inc.
• Stacy and Donald Rosenberg
• Marie G. Schrup
• Stephanie and Stephen Williams
Please Donate
Team led by Jamey Marth awarded $12.8M to develop new ways to prevent sepsis

Jamey Marth, Ph.D., is part of a team of scientists from leading medical research institutes who received a $12.8M grant to improve the outcome for patients with sepsis — a primary cause of death from infection also known as "blood poisoning."

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Robert Wechsler-Reya only San Diego researcher to receive St. Baldrick's grant

Robert Wechsler-Reya, Ph.D., received a $100,000 grant from the St. Baldrick's Foundation to advance research in medulloblastoma, the most common malignant brain tumor in children. 

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