IATDMCT TDM Education India Webinar

The IATDMCT TDM in India webinar, held on October 8, 2025, showcased cutting-edge innovations in micro sampling devices and best practices in TDM that are shaping the future of precision medicine both in India and globally with insights from the past about a modest beginning of the TDM practices in India. The webinar was chaired by Dr. Nilima A. Kshirsagar and Dr. Smita Pattanaik, moderated by Dr. Sumith Mathew, Dr. Roopali Somani and Dr. Vishnu Eriyat.

Presentations and Learning Objectives

• Dr. Christophe Stove, President of the IATDMCT, presented the various types of microsampling devices, technologies, their advantages and shortcomings. He further discussed about the issues in standardization and their global impact on TDM practices.
• Dr. Nilima A. Kshirsagar, India’s leading Clinical Pharmacology expert and World Health Organization consultant, reflected on 50 years of TDM (1975–2025) and outlined future directions for the field in India.
• Dr. Bhaskar K and Dr. Shivakrishnarao T from KEM Hospital shared evidence-based strategies for determining optimal sampling time-points, crucial for accurate drug monitoring and patient safety.

The speakers facilitated discussions linking practical applications to current clinical challenges.

Key Learning Points

• Participants learned about Microsampling technologies revolutionizing TDM, enabling precise, less invasive sample collection.
• Insights were shared on 50 years of TDM in India and strategies to advance practice for the next decade.
• Attendees understood the Science of Sampling time-points for accurate interpretation of TDM results.
• Practical tips on implementing Global TDM standards in Indian clinical settings were discussed.

Impact

The webinar benefited over 100 participants from across India, including clinicians, pharmacologists, and laboratory specialists from institutions like KEM Hospital and Seth GS Medical College, Mumbai. By addressing challenges in sample timing, assay technology, and interpretation, the training strengthens precision medicine efforts and supports safer, more effective drug therapy.

Snapshot of Dr. Christophe Stove, IATDMCT President, presenting on
microsampling technologies transforming TDM.

Snapshot of the interactive Q&A session, with speakers addressing queries
from participants via the chatbox.

Snapshot of participants from the Department of Pharmacology, PGIMER, Chandigarh,
attending the webinar together.

Impact

Recordings and materials from the webinar are made available for the members on the IATDMCT website

IATDMCT Member Spotlight from Young Scientists Committee

Featured Member:
Cindy Lau, BPharm, PhD, GradCert PharmPrac

Committee:
Young Scientists Committee

Affiliation / Position:
Antimicrobial Stewardship Pharmacist, St Vincent’s Hospital Sydney, Australia

Years of IATDMCT Membership:
Member since 2017

Area of Expertise:
Clinical implementation of antimicrobial therapeutic monitoring (TDM)

Brief Biography:
Cindy is a clinician researcher who advocates for the clinical application of antimicrobial TDM whilst working as an antimicrobial stewardship pharmacist. Her research interests include antimicrobial toxicity and TDM, particularly linezolid and cefepime, and optimizing management of infections in immunocompromised and critically unwell patients.

Current Focus or Projects:
Cindy is currently aiming to further finesse antimicrobial toxicity thresholds and investigate the impact of TDM in reducing antimicrobial side effects. She is also interested in expanding the role of Australian pharmacists in antimicrobial TDM in clinical settings.

Learn More:
Visit the Young Scientists Committee page: https://iatdmct.org/all-committees/young-scientists/

IATDMCT Congress 2025 – Singapore, September 21 – 24

The Congress was an in-person event that welcomed the members to the Grand Copthorne Waterfront Hotel, Singapore!

IATDMCT 2025 benefitted from the presentations of leading international scientists, young scientists and industry partners from all over the world. Participants represented scientific and practice areas of clinical biochemistry, pharmacy, environmental toxicology, occupational medicine, pharmacology, analytical and clinical chemistry, clinical toxicology, and the forensic sciences. The theme of the congress was "Creative solutions for global challenges".

Here is the information about the awards presented at the IATDMCT 2025 Singapore Congress!

IATDMCT Awards:

• IATDMCT Irving Sunshine Award for Outstanding Contributions to Clinical Toxicology
  • Presented to Vanessa Steenkamp, University of Pretoria, South Africa
     

    

    Irving Sunshine Award: Dr. Vanessa Steenkamp (University of Pretoria)

• IATDMCT Patsalos Prize for the Best TDM Manuscript published in Therapeutic Drug Monitoring
  • This award is sponsored by Dr. & Mrs. Philip N. Patsalos
  • Presented to Marlotte van der Veer, Amsterdam University Medical Center, The Netherlands
    Article: "Predictive Performance of a Gentamicin Pharmacokinetic Model in Term Neonates with Perinatal Asphyxia Undergoing Controlled Therapeutic Hypothermia"
     

    

    Patsalos Prize: Dr. Marlotte van der Veer (Amsterdam University Medical Center)

Young Scientists Awards:

• Best Young Scientist Oral Presentation
  • Kevin Vandenbroucke, Ghent University, Belgium
  "Does microsampling enhance preanalytical stability of uracil in dihydropyrimidine dehydrogenase (DPD) phenotyping?"
   

  

  Young Scientist Award: Best Oral: Kevin Vandenbroucke (Ghent University)

• Best Young Scientist Poster Presentation
  • Siobhonne Breen, Monash University, Australia
    "Dual β-lactam therapy for high-risk Pseudomonas aeruginosa ST235-clone clinical isolates"
     

    

    Young Scientist Award: Best Poster: Siobhonne Breen（Monash University

Best TDM Presentations:

• Best TDM Oral Presentation
  • Jennifer Marie Gibson, University of California, USA
    "Seconds-resolved measurements of the transport of methotrexate into the interstitial fluid"
    and
    Nathalie Grace Sy Chua,Singapore General Hospital, Singapore
    "Should Beta-lactams and Beta-lactamase-Inhibitors Be Co-Formulated? Insights from Beta-lactam Therapeutic Drug"
     

    

    Best Oral Award: TDM: Nathalie Grace Sy Chua (Singapore General Hospital)

    

    Best Oral Award: TDM: Jennifer Marie Gibson (University of California)

• Best TDM Poster Presentation
  • Yi Ma, Peking University Third Hospital, China
    "TDM of Erythrocyte Methotrexate Polyglutamates in Rheumatoid Arthritis? A Prospective Study"
     

    

    Best Poster Award: TDM: Yi Ma (Peking University Third Hospital)

Best Clinical Toxicology Presentations:

• Best Clinical Toxicology Oral Presentation
  • Lea Wagmann, Saarland University, Germany
    "In Vitro Biotransformation of Six Compounds Derived from the Stimulant Prolintane"
     

    

    Best Oral Award: Clinical Toxicology: Lea Wagmann (Saarland University)

• Best Clinical Toxicology Poster Presentation
  • Melissa Bennett, University of Calgary, Canada
    "The Illicit Fentanyl Landscape: Trends, Concentrations and Co-Occurrences"
     

    

    Best Poster Award: Clinical Toxicology: Melissa Bennett (University of Calgary)

Congratulations to all!!

The human microbiome, a complex community of bacteria, fungi, protozoa, and viruses, doesn't just passively coexist with the drugs we take; it actively participates in a bidirectional relationship that can impact drug efficacy and toxicity. From immunosuppressants in transplant patients to medicines in other fields of medicine, it is becoming apparent that the microbiome has been a missing piece in our understanding of drug variability, and that it can uniquely impact drug interactions. As this field rapidly evolves, it promises new strategies for personalising medicine through microbiome biomarkers and targeted manipulation of our microbial communities. We are joined by Laure Elens and Roland Lawson to discuss this evolving field.

Listen Now!

In this issue:

• Optimizing Antibiotic Therapy in Critically Ill Patients
• Pros and Cons of Hair Analysis in Environmental Toxicology
• Is There a Room for Personalized Dosing of Trastuzumab Deruxtecan?
• Model-Informed Precision Dosing (MIPD) of Cancer Drugs: Hype or Reality?
• TDM: Transforming a Vision into Best Practice for Healthcare in Indonesia
• 2025 Charles Lieber Memorial Satellite Symposium
• JSTDM-IATDMCT Young Scientist Joint Symposium 2025
• Believers Hospital Launches Therapeutic Drug Monitoring Facility to Enhance Precision in Patient Care

Available in your choice of format:                  

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Stay ahead with the latest scientific research developments in the fields of TDM and CT!

The monthly Therapeutic Drug Monitoring column provides you with the latest posts of ahead-of-print. Bringing to you articles posted online August 15 – November 5, 2025:

ORIGINAL ARTICLES:

• Pyrethroid Exposure in Premature Newborns: A Pilot Study on Materno–Fetal Transmission and Early Postnatal Evolution
  Bressin, Pauline; El Balkhi, Souleiman; El Hamel, Chahrazed; Yardin, Catherine; Guigonis, Vincent; Saint-Marcoux, Franck; Ponthier, Laure
  October 31, 2025
• Evaluation of the Real-World Practice of Model-Informed Therapeutic Drug Monitoring and Its Association With Pharmacokinetic Target Attainment Rates: A Large-Scale, Single-Center Retrospective Study
  Kim, Yoonjin; Kang, Jaegu; Song, Jisoo; Park, Jiyeon; Bae, Sungyeun; Kim, Byungwook; Lee, SeungHwan; Yu, Kyung-Sang; Huh, Ki Young
  October 28, 2025
• Broad-Spectrum Drug Screening Positivity Rates in Pediatrics and Adults: The Reference Laboratory Perspective
  Shean, Ryan C.; Johnson-Davis, Kamisha L.
  October 10, 2025
• Development and Evaluation of Multimodel Informed Precision Dosing Tool for Optimizing Vancomycin Therapy in Pediatric Patients
  Yuan, Yawen; Xu, Li; Xi, Yueling; Huang, Zhonghui; Cao, Jing; Li, Zhiling; Standing, Joseph F.
  October 8, 2025
• Cefepime Pharmacokinetics in Patients Receiving Extracorporeal Membrane Oxygenation
  Maranchick, Nicole F.; Jaudon, Andrew; Aparanji, Siya; Carruthers, Emma; Rodriguez, Nathalia; Phillips, Cristina; Knott, David; Shahmohammadi, Abbas; Peloquin, Charles A.; Alshaer, Mohammad H.
  October 3, 2025
• Liquid Chromatography–Tandem Mass Spectrometry Method for Simultaneous Quantification of Four Endocannabinoids and Endocannabinoid-Like Substances in Plasma: Application in an HIV—Hepatitis C Virus Coinfected Population
  Gish, Alexandr; Radwan, Eqbal; Richeval, Camille; Protopopescu, Camelia; Wiart, Jean-François; Hakim, Florian; Allorge, Delphine; Carrieri, Patrizia; Barré, Tangui; Gaulier, Jean-Michel
  October 2, 2025
• Limited Sampling Strategy of Rosuvastatin Single-Time-point Concentrations Accurately Estimate Exposure and Constitutive Transporter Activities in Healthy Adults
  Barry, Ryan; Liu, Catherine; Paine, Mary F.; Tomlinson, Brian; Ma, Joseph D.
  October 1, 2025
• Simultaneous Quantification of Dexamethasone and Cortisol for the Dexamethasone Suppression Test Using LC-MS/MS: Adaptation of a Commercial CE-IVD Steroid Assay
  Steiner, Regula; Luginbühl, Marc
  September 30, 2025
• Cyclosporin A Monitoring in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: A Comparison Between Siemens Viva-ProE System and LC-MS/MS
  Lin, Rongqi; Fan, Xianghui; Li, Xueyong; Lai, Guixiang; Chen, Ming; Huang, Yingbin; Fu, Qinghui; Lai, Kaixian; Cheng, Yu; Wu, Xuemei; Qiu, Hongqiang; Chen, Yisheng
  September 29, 2025
• Correlation Between Escitalopram, Sertraline, and Fluoxetine Serum Levels and QTc Interval Prolongation in Children and Adolescents
  Warrings, Wiebke; Taurines, Regina; Egberts, Karin; Keicher, Franca; Romanos, Marcel; Fekete, Stefanie
  September 26, 2025
• Simultaneous Quantification of Azole Antimycotics in Quantitative Dried Blood Spots: A Step Toward Home Sampling for Therapeutic Drug Monitoring
  Li, Shengbin; Liu, Boyu; Yuan, Jinghua; Yao, Wanqing; Luo, Panchao; Yizheng, Xie; Wang, Junlin; Su, Lan; Xiaoran, Hou; Yuan, Hengjie; Cai, Zengxuan; Chen, Qi
  September 26, 2025
• Paracetamol Half-Life Declines over Time After an Acute Overdose
  Kroes, Johannes A.; Poortvliet, Jeroen; Touw, Daan J.; Oortgiesen, Berdien E.; Sturkenboom, Marieke G.G.
  September 24, 2025
• Simultaneous Quantification of Bictegravir and Emtricitabine Using a Simple and Economical Liquid Chromatography–Ultraviolet Method for Therapeutic Drug Monitoring in Patients with Human Immunodeficiency Virus
  Bai, Haihong; Fang, Yuan; Wang, Zihe; Zhang, Yang; Zhang, Tong; Liu, Wei
  September 23, 2025
• Toward Clinical Implementation of a Volumetric Absorptive Microsampling–Based Method for Dasatinib and Imatinib Therapeutic Drug Monitoring
  Verougstraete, Nick; Mazure, Dominiek; Stove, Christophe P.
  September 18, 2025
• Population Pharmacokinetic Model of Lacosamide in Chinese Children and Adults with Epilepsy
  Wu, Ruoyun; Liu, Shanshan; Zhao, Zhigang; Mei, Shenghui
  September 17, 2025

REVIEW ARTICLES:

• To Convert or Not to Convert? Official International Association of Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Considerations and Recommendations for Converting Capillary Blood Microsampling Concentrations to Plasma Concentrations
  Boffel, Laura; De Baets, Hanna; Heughebaert, Liesl; Rispens, Theo; Åsberg, Anders; Shipkova, Maria; de Winter, Brenda C. M.; Moes, Dirk Jan A. R.; de Vries, Annick; Alffenaar, Jan-Willem C.; Stove, Christophe P.
  November 5, 2025
• Therapeutic Drug Monitoring of Elexacaftor, Tezacaftor, and Ivacaftor: An Overview of Bioanalytical Methods
  Cafaro, Alessia; Barco, Sebastiano; Castellani, Carlo; Cangemi, Giuliana
  November 3, 2025
• Treatment of Acute Paracetamol Overdose: A Comprehensive Overview
  Koppen, Arjen; Mian, Paola; Sturkenboom, Marieke G. G.
  October 31, 2025
• Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges
  Carrara, Sandro; Widmer, Nicolas; Rodino, Francesca; Du, Lin; Briki, Myriam; Decosterd, Laurent A.; Marzolini, Catia; Buclin, Thierry; Thoma, Yann; Guidi, Monia
  October 7, 2025
• Therapeutic Drug Monitoring of Oral Targeted Anticancer Drugs: Achievements, Experiences, Challenges, and the Path Forward
  van der Kleij, Maud B. A.; Groot Beumer, Karolijn W. M.; Koolen, Stijn L. W.; Mathijssen, Ron H. J.; Steeghs, Neeltje; Huitema, Alwin D. R.
  September 24, 2025
• Comprehensive Review of the Application of Aptamer-Based Point-Of-Care Sensors for Therapeutic Drug Monitoring
  Shi, Chunjie; Li, Qiaoqiao; Tang, Tiantian; Liu, Yang; Huang, Yuxin; Qin, Wanxia; Liu, Zhenya; Wang, Yuanqiang; Chen, Wanyi; Li, Lixian
  September 19, 2025

LETTER TO THE EDITOR:

• Methylene Blue–Induced False-Positive Amphetamine Results in Urine Drug Screening: Two Case Reports
  Leegwater, Emiel; Jager, Nynke G. L.
  October 8, 2025

ABSTRACTS:

• Abstracts for 22nd International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Banff, Alberta, Canada, September 15–18, 2024
  September 22, 2025

GRAND ROUNDS:

• Therapeutic Drug Monitoring Versus Fixed-Interval Dosing of Dalbavancin in Implant-Associated Spinal Infections: Grand Round/A Case Study
  Houwen, Jeroen P.A.; Hakkers, Charlotte S.; Schweitzer, Valentijn A.; Bognàr, Tim; Toren-Wielema, Martha L.; Touw, Daniël J.; de Vries Schultink, Aurelia H.M.
  September 19, 2025
• Precision Dosing of Meropenem in a Neonate on CARPEDIEM Dialysis: A Grand Round
  Morales Junior, Ronaldo; Diseroad, Emily; Hutson, Tamara; Schuler, Erin E.; Hambrick, H. Rhodes; Goldstein, Stuart L.; Tang Girdwood, Sonya
  September 16, 2025

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TDM Education India – December 3 at 4:30 PM - 6:00 PM (India time / UTC +05.30)

REGISTER NOW!

Guest Lecture: Model-informed and AI-driven Precision Dosing in Pediatrics
Dr. Tomoyuki Mizuno
Associate Professor of Pediatrics
Director, Pharmacometrics Center of Excellence
Director, Clinical Pharmacokinetics Consultation Service
Division of Translational and Clinical Pharmacology
Cincinnati Children's Hospital Medical Center
Cincinnati, USA

Presentation: When Standard Therapy Fails: Leveraging TDM for Clinical Success
Dr. Bharathan Somu
Infectious Disease Physician
Believers Church Medical College and Hospital (BCMCH)
Thiruvalla, Kerala, India

Presentation: Importance of achieving adequate antibiotic exposure early in the treatment period (even before culture reports)
Dr. Sumith K. Mathew
DM Professor 
Believers Church Medical College and Hospital (BCMCH)
Thiruvalla, Kerala, India

Register Now

SAVE THE DATES!

IATDMCT 2026
September 27-30, 2026
Rennes, France

Co-editor: Manuela Neuman
Co-editor: Ryuji Kato
Co-editor: Miao Yan

NOTE: Items appearing in the IATDMCT monthly E-News do not necessarily have the endorsement of the Association.