IATDMCT Congress 2024 – Banff, Canada (Sep 15 – 18)

The Congress was an in-person event that welcomed the members to the Banff Centre for Arts and Creativity in Banff, Canada!

IATDMCT 2024 benefitted from the presentations of leading international scientists, young scientists and industry partners from all over the world. Participants represented scientific and practice areas of clinical biochemistry, pharmacy, environmental toxicology, occupational medicine, pharmacology, analytical and clinical chemistry, clinical toxicology, and the forensic sciences. The theme of the congress was "Exploring New Frontiers in TDM and Toxicology".

Congress Co-Chairs Penny Colbourne and David Kinniburgh welcomed participants on behalf of the Organizing Committee.

The Pre-Congress Symposium (Sep 15/2024) was entitled "New Frontiers in Clinical Toxicology". The topics included wastewater testing for drugs, drug checking services and the discovery of novel psychoactive substances with artificial intelligence.

Roundtables presented were:

• Gut microbiome in individual variability to drug response
• The controversy on statin health outcomes: a gap between fundamental science and clinical evidence
• What is the molecularly imprinted? How will molecularly imprinted sensors change the world of TDM?
• Challenges of High-Resolution Mass Spectrometry for Drug Testing
• TDM of biologics in oncology is there room for personalized dosing for anti-body drug conjugates
• Discussion & Guide to Implementing a Successful Beta-Lactam Therapeutic Drug Monitoring Program
• Unsafeness of uncontrolled, so-called edible cannabinoid products containing HHC: lessons to be learned from recent incidents in Czech schoolchildren and adolescents
• Use of the hollow fiber infection model to generate PK-PD targets in humans
• Reflections on the use of the direct alcohol biomarker PEth in clinical and forensic toxicology
• Personalized medicine substance of use and misuse: the role of clinical laboratories

We are looking forward to seeing members next year in Singapore!

The Communication Committee held a symposium at the Banff Congress on "Future Prospects for Preventive Medicine Applying Pharmacogenomics, Metabolomics, Proteomics, and Microbiome".

Co-Chairs:
Ryuji Kato, Osaka Medical and Pharmaceutical University, Japan
Ofelia Noceti, National Center for Liver Transplantation and Liver Diseases, Uruguay

The scope of this session:

• Discuss the role of Metabolomics and Microbiome as tools for individualized healthcare.
• Discuss the role of damage associated molecular patterns as a predictive biomarker of drug induced liver injury.
• Future prospects for preventive medicine through the application of pharmacogenomics, metabolomics, proteomics and microbiomics.

Presentations:

Metabolomics as a promising tool for individualized healthcare
Ofelia Noceti, National Center for Liver Transplantation and Liver Diseases, Uruguay

Microbiome and Inflammasome in Gastrointestinal Diseases
Manuela Neuman, University of Toronto, Canada

Damage associated molecular patterns as a predictive biomarker of drug induced liver injury
Ryuji Kato, Osaka Medical and Pharmaceutical University, Japan

In this issue:

• Launch of the IATDMCT Mentor-Mentee Program
• Meet the IATDMCT Young Scientist Committee!
• Oral fluid: a potential alternative matrix for mycophenolate TDM in paediatric patients
• Dried blood sampling: challenges and opportunities in OPAT

Available in your choice of format:                  

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We are inviting members interested to join the Communication Committee to assist in the management of social media (Twitter and Website).

Please send an email to Dr. Ryuji Kato (ryuji.kato@ompu.ac.jp) and Dr. Ofelia Noceti (ofelianp@gmail.com), which includes a resume or CV and explanatory note saying which area you would like to be involved in. We are looking forward to your applications!

Find the latest news and follow our IATDMCT institutional page on LinkedIn, X(Twitter) @IATDMCT or Instagram!

Stay ahead with the latest scientific research developments in the fields of TDM and CT!

The monthly Therapeutic Drug Monitoring column provides you with the latest posts of ahead-of-print. Bringing to you articles posted online August 6 – september 18, 2024:

ORIGINAL ARTICLES:

• Model-Informed Dosing Optimization of Tacrolimus for Concomitant Administration with Itraconazole to Japanese Lung Transplant Recipients
  Takahashi, Ren; Itohara, Kotaro; Nakagawa, Shunsaku; Katada, Yoshiki; Sugimoto, Mitsuhiro; Umemura, Keisuke; Matsumura, Katsuyuki; Hira, Daiki; Tsuda, Masahiro; Katsube, Yurie; Tanaka, Satona; Ohsumi, Akihiro; Nakajima, Daisuke; Nagao, Miki; Date, Hiroshi; Terada, Tomohiro
  August 6, 2024
• Simultaneous Determination of Ripretinib and Its Desmethyl Metabolite in Human Plasma Using LC-MS/MS
  Qian, Zhou-Yi; Wang, Ping; Wang, Zi-Yi; Zhao, Yang; Du, Tian-Tian; Xu, Hao; Wang, Yong-Qing; Sun, Lu
  August 6, 2024
• Development and Validation of a Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Therapeutic Drug Monitoring of Ceftolozane and Tazobactam in Human Plasma Microsamples
  Conti, Matteo; Giorgi, Beatrice; Gatti, Milo; Viale, Pierluigi; Pea, Federico
  August 6, 2024
• A Refined Population Pharmacokinetic Model–Based Guideline for Individualized PEGasparaginase Dosing in Pediatric Acute Lymphoblastic Leukemia
  Brigitha, Leiah J.; Zaky, Karen; Pieters, Rob; van der Sluis, Inge M.
  August 13, 2024
• Dried Blood Spot Method Development and Clinical Validation for the Analysis of Elexacaftor, Elexacaftor-M23, Tezacaftor, Tezacaftor-M1, Ivacaftor, Ivacaftor Carboxylate, and Hydroxymethyl Ivacaftor Using LC-MS/MS
  Vonk, Steffie E. M.; van der Meer-Vos, Marloes; Kos, Renate; Neerincx, Anne H.; Terheggen-Lagro, Suzanne W. J.; Altenburg, Josje; Maitland-van der Zee, Anke H.; Mathôt, Ron A. A.; Kemper, E. Marleen; on behalf of the Amsterdam Mucociliary Clearance Disease (AMCD) research group
  August 27, 2024
• Association of Plasma Cabozantinib Concentration With Treatment Response and Adverse Events in Japanese Patients With Advanced Renal Cell Carcinoma
  Maruyama, Shinichi; Kobayashi, Hiroaki; Hiraga, Tatsuru; Anno, Tadatsugu; Sanjo, Tansei; Arai, Masashi; Ishida, Masaru; Kanno, Hiroshi; Kato, Masaru
  August 29, 2024
• Pharmacokinetic and Pharmacodynamic Assessment of Valganciclovir in Infants With Congenital Cytomegalovirus Infection
  Itohara, Kotaro; Yamamoto, Kazuhiro; Fujinaka, Shunsuke; Hashimoto, Mari; Tamura, Naoki; Kitahiro, Yumi; Omura, Tomohiro; Fujioka, Kazumichi; Yano, Ikuko
  September 4, 2024
• Population Pharmacokinetic Modeling of Pyrazinamide Among Chinese Patients With Drug-Sensitive or Multidrug-Resistant Tuberculosis
  Chen, Shuyan; Rao, Weiqiao; Fu, Liang; Liu, Guohui; Zhang, Jiancong; Liao, Yunli; Lv, Ning; Deng, Guofang; Yang, Shijin; Lin, Liang; Li, Lujin; Qu, Jiuxin; Liu, Siqi; Zou, Jin
  September 6, 2024
• Development and Validation of a High-Performance Liquid Chromatography–Ultraviolet Spectrometry Method for Ampicillin and its Application in Routine Therapeutic Drug Monitoring of Intensive Care Patients
  Morath, Benedict; Schultes, Linda; Frey, Otto Roman; Röhr, Anka Christa; Christow, Hannes; Hoppe-Tichy, Torsten; Brinkmann, Alexander; Chiriac, Ute
  September 18, 2024

REVIEW ARTICLE:

• Implementation and Evaluation Strategies for Pharmacogenetic Testing in Hospital Settings: A Scoping Review
  Wu, Angela; Raack, Edward J.; Ross, Colin J. D.; Carleton, Bruce C.
  September 11, 2024

GRAND ROUNDS:

• Daptomycin Dosage Optimization in Renal Impairment Using Model-Informed Precision Dosing
  Sayadi, Hamza; Fromage, Yeleen; Labriffe, Marc; Danthu, Clément; Monchaud, Caroline; Woillard, Jean-Baptiste
  September 10, 2024

SHORT COMMUNICATION:

• The Case of Dolutegravir Plus Darunavir Antiretroviral Regimens: Is It Always Useful to Double the Drug Doses? A Short Communication
  Cattaneo, Dario; Ridolfo, Anna Lisa; Giacomelli, Andrea; Castagna, Antonella; Dolci, Alberto; Antinori, Spinello; Gervasoni, Cristina
  September 5, 2024

››Submit your high quality research – Information for authors.

Left to right: Ofelia Noceti, Manuela Neuman and Ryuji Kato at the Communications Committee symposium in Banff.

PRESENTERS:

Ofelia Noceti
Centro Nacional de Tratamientos Hepatobilio-Pancreáticos, Unid Docente Asistencial, Centro Nacional Hepatobilio-pancreático Servicio de Enfermedades Hepáticas, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
Title: Metabolomics as a tool for individualized healthcare

Manuela Neuman
In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Canada
Title: Microbiome and Inflammasome in Gastrointestinal Diseases

Ryuji Kato
Department of Pharmacotherapeutics and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka, Japan
Title: Damage associated molecular patterns as a predictive biomarker of drug induced liver injury

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Co-editor: Manuela Neuman
Co-editor: Ryuji Kato
Co-editor: Miao Yan

NOTE: Items appearing in the IATDMCT monthly E-News do not necessarily have the endorsement of the Association.