The IATDMCT flag has been transferred to the local organizing Committee of the 21st IATDMCT Congress in Oslo, Norway, September 24-27, 2023. The theme is “Personalized under the Northern Sky”

Please consider participating in our next IATDMCT Congress!

This month we hear from Young Scientist, Guido Trezeguet. Guido is pursuing his PhD at the Paediatric Hospital Dr. Juan P Garrahan in Buenos Aires, Argentina. We met in person at the recent Prague congress, and I was very impressed with his work related to cell free DNA for the detection of acute graft rejection. Although the technique he is working on may enable wider clinical application due to reduced cost compared to earlier approaches, there are particular challenges in the paediatric setting. Looking forward to hearing developments arising from Guido’s work!

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Last month we missed publishing the companion blog introducing the podcast. In the blog we share a few details about how the blog came to be, we explain the name and what you can expect from the podcast format. Join us every two months on your favourite podcast platform.

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In this issue:

• Statistics of the Prague Congress
• Reports of the Scientific Committees
• Spotlight on New Members
• Weekend with scientific meetings in Madrid (October 7-8th): Update in Personalized Immunosuppression and TransplantCare, “A future full of hope”

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Stay ahead with the latest scientific research developments in the fields of TDM and CT!

The monthly Therapeutic Drug Monitoring column provides you with the latest posts of ahead-of-print. Bringing to you articles posted online September 29 – November 9, 2022:

ORIGINAL ARTICLES:

• Therapeutic Drug Monitoring of Ganciclovir in Cytomegalovirus-Infected Patients with solid organ Transplants and Its Correlation to Efficacy and Toxicity.
  van der Wekken-Pas, L.C.; Totté, J.E.E.; Lunel, F. Verduyn; van Zuilen, A.D.; van Luin, M.
  November 09, 2022
• Validation of Conversion Factors for Therapeutic Drug Monitoring of Lacosamide, Lamotrigine, and Levetiracetam in Dried Capillary Blood.
  Hagemann, Anne; Klimpel, Dennis; Schmitter, Elisabeth; Bien, Christian G.; Dufaux, Bertin; May, Theodor W.; Brandt, Christian.
  October 26, 2022
• Population Pharmacokinetic Analysis of Drug–drug Interactions between Perampanel and Carbamazepine Using Enzyme Induction Model in Epileptic Patients.
  Fujita, Yuito; Murai, Mariko; Muraki, Shota; Suetsugu, Kimitaka; Tsuchiya, Yuichi; Hirota, Takeshi; Matsunaga, Naoya; Ieiri, Ichiro.
  October 24, 2022
• Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach.
  Piscitelli, Joseph; Nikanjam, Mina; Capparelli, Edmund V.; Blaquera, Chelsea L.; Penzak, Scott R.; Nolin, Thomas D.; Paine, Mary F.; Ma, Joseph D.
  October 24, 2022
• Development and evaluation of a height-based tobramycin initial dosing nomogram for the treatment of adult cystic fibrosis pulmonary exacerbations.
  El Hassani, Mehdi; Thirion, Daniel J. G.; Koloskoff, Kevin; Matouk, Elias; Simard, Chantale; Cloutier, Isabelle; Pilote, Sylvie; Marsot, Amélie.
  October 19, 2022
• Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines.
  Hoste, Emilia; Paquot, Adrien; Panin, Nadtha; Horion, Shaleena; El Hamdaoui, Halima; Muccioli, Giulio G; Haufroid, Vincent; Elens, Laure.
  October 11, 2022
• Impact of ABCC2 1249G>A and -24C>T polymorphisms on lacosamide efficacy and plasma concentrations in Uygur pediatric epilepsy patients in China.
  Zhao, Ting; Li, Hong-jian; Feng, Jie; Zhang, Hui-lan; Yu, Jing; Sun, Yan; Yu, Lu-hai.
  October 10, 2022
• Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis.
  Fukumoto, Shiori; Ohbayashi, Masayuki; Okada, Akira; Kohyama, Noriko; Tamatsukuri, Tatsuro; Inoue, Hideki; Kato, Akihito; Kotani, Toru; Sagara, Hironori; Dohi, Kenji; Kogo, Mari.
  October 07, 2022
• Peptide Mimotope-enabled Quantification of Natalizumab Arm Exchange during Multiple Sclerosis Treatment.
  Page, Lesley J.; Lagunas-Acosta, Jacqueline; Heussen, Raphaela; Castellana, Edward T.; Messmer, Bradley T.
  October 06, 2022
• Pharmacodynamic Monitoring of Ciclosporin and Tacrolimus: Insights from Nuclear Factor of Activated T Cell-Regulated Gene Expression in Healthy Volunteers.
  Djaelani, Yoana Aurelia; Giese, Thomas; Sommerer, Claudia; Czock, David.
  October 01, 2022
• Application of user-centered co-design principles to address barriers in therapeutic drug monitoring.
  Wong, Sherilyn; Davis, Aaron; Selby, Philip R.; Khoo, Richie; Gwilt, Ian; Stocker, Sophie L.; Ward, Michael B.; Reuter, Stephanie E.
  October 01, 2022
• Pharmacist-Driven Therapeutic Infliximab Monitoring at the Point Of Care Using Rapidly Assessed Drug Levels In Patients with Inflammatory Bowel Disease.
  Rentsch, Clarissa A.; Ward, Mark G.; Luber, Raphael P.; Taylor, Kirstin M.; Gibson, David J.; Headon, Belinda; Rosella, Ourania; Su, Heidi Y.; Friedman, Antony B.; Dooley, Michael; Sparrow, Miles P.; Gibson, Peter R.
  September 29, 2022

REVIEW ARTICLE:

• Influence of Genetic Polymorphisms on the Pharmacokinetics of Trazodone Hydrochloride: a Scoping Review and Future Perspective.
  Meulman, Jessica; Visacri, Marília Berlofa; Moriel, Patricia.
  October 01, 2022

SHORT COMMUNICATIONS:

• Subtherapeutic exposure of ganciclovir in children despite appropriate dosing: a short communication.
  Marfil, Sjanene; Märtson, Anne-Grete; Toren-Wielema, Marlous; Leer-Buter, Coretta; Schölvinck, Elisabeth H.; Alffenaar, Jan-Willem C.; Touw, Daan J.; Sturkenboom, Marieke G. G.
  November 02, 2022
• Immunosuppressant Monitoring – Performance of the First Mass Spectrometry-Based Automated Clinical Analyzer Cascadion.
  Denis, Grote-Koska; Stefan, Czajkowski; Antje, Staaden; Korbinian, Brand.
  October 27, 2022
• Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?.
  Grit, Geeske F; Toren-Wielema, Marlous L; Colin, Pieter J.; Touw, Daan J.
  October 26, 2022

CASE REPORT:

• THE EFFECT OF THERAPEUTIC PLASMA EXCHANGE ON ITRACONAZOLE PHARMACOKINETICS: A CASE STUDY.
  Seah, Vincent; Sreeharan, Thulashigan; Kocic, Danijela; Reuter, Stephanie E; Girgis, Laila; Marriott, Deborah J E; Stocker, Sophie L.
  November 1, 2022

LETTER TO THE EDITOR:

• Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts Varies as a Function of Screening Criterion Used.
  Ferretti, Morgan L.; Vandrey, Ryan; Irons, Jessica G.; Jackson, Heather; Loflin, Mallory J.; Hyke, Travis; Bonn-Miller, Marcel O.
  October 3, 2022

EDITORIAL:

• New Immunoassays in TDM: Where is the Journey Heading?.
  Salamone, Salvatore J.; Courtney, Jodi B.; Clarke, William A.
  October 01, 2022

››Submit your high quality research – Information for authors.

The Communication Committee would like to inform the membership that advertisements for professional positions (Ph.D. and Post-Doc job opportunities) in the field of TDM/CT, will be published in the E-news instead of on the IATDMCT website. Please e-mail the office with the advertisement for the position and it will be published in an upcoming monthly E-news. (IATDMCT office email: info@iatdmct.org)

The Communication Committee is also working in IATDMCT Website frames settings to provide better service to members.

» Click here to Post an Event on our Online Events Calendar today!

Visit the IATDMCT Events Calendar and stay informed about the upcoming TDM and CT Meetings. By doing this you can comfortably and directly reach all related online resources.

This dynamic one-day meeting is geared towards drug developers, pharmacologists, policy makers, pharmacists, and clinicians.

Time: Friday 09 December 2022, 09:00 - 17:00
Location: The Amsterdam Public Library | Openbare Bibliotheek Amsterdam (OBA), Oosterdokskade 143, 1011 DL in Amsterdam
Website: https://sanquinacademy.nl/en/offers/symposium-therapeutic-drug-monitoring-of-biologics-towards-personalised-medicine/

Programmed topics:

• Finding the therapeutic window; dose finding challenges
• Clinicians’ perspective on optimized dosing schedules
• Personalised dosing: reduction and stopping
• What can we learn from anti-cancer biologics?
• Sharing trade secrets; combine knowledge between biologics and diseases
• Deeper understanding of the PK of biologics
• Clinical pharmacology to enable the development of personalised/stratified medicines
• Impact of antibody structure and pharmacogenetics on PK
• Models for immunogenicity of biologics: how to prevent, how to handle?
• The regulator’s view: ‘How much use is in the label’?
• The pharmaceutical industry’s view on TDM
• Point of care and dashboard applications in practice
• Patient perspective on TDM

IATDMCT members can register as academic and get 50% discount.

IADTMCT members who cannot attend in Amsterdam can approach Annick deVries, Chair of the TDM of Biologics Committee (Annick.deVries@sanquin.nl).

Over the past decades many outstanding achievements, many important milestones have been accomplished contributing to the IFCC’s mission of“Advancing excellence in laboratory medicine for better healthcare worldwide”. These achievements have not only contributed to the growth of the IFCC but have had an important impact on advancing the science of laboratory medicine and in vitro diagnostics around the world. The future holds considerable promise for the IFCC and its family of national societies and corporate members. The strong foundation built by thousands of IFCC officers over the past decades will ensure the IFCC’s continued journey towards global leadership in laboratory medicine, contributing to its most valuable mission of improving clinical decision making and better healthcare worldwide.

The IFCC General Conference 2022 and the celebration for the 70 years of IFCC Global Leadership of Laboratory Medicine took place in Brussels with enthusiasm, memories and perspectives for the future. Almost all the IFCC people, the people who make it possible that this organization plays such an important role in the laboratories all over the world. The President’s message, Prof. Khosrow Adeli offered a detailed report of every particular day of the conference. The next IFCC General Conferences will be held:
XXV Rome (ITALY) 2023
XXVI Dubai (UNITED ARAB EMIRATES) 2024

Co-editor: Manuela Neuman
Co-editor: Ryuji Kato
Co-editor: Miao Yan

NOTE: Items appearing in the IATDMCT monthly E-News do not necessarily have the endorsement of the Association.