Dear Researcher,

IBA1 (Ionized Calcium Binding Adapter Molecule 1) is an actin-binding protein that is expressed specifically in activated microglia. Microglia activation is an inflammatory response, but chronic expression contributes to several neurodegenerative disorders, including Parkinson’s disease and Alzheimer’s disease, multiple sclerosis, stroke and traumatic brain injury (TBI).

IBA1 is widely considered as an immunohistochemical (IHC) marker useful for the detection of these changes occurring in microglia. Most researchers use Immunofluorescence (IF) staining for these studies and Biosensis' antibodies have been shown to be ideal for this purpose.

IF image of the rat cerebellar layer stained with RPCA-IBA1 (green) and costained with CPCA-MAP2 (red). Nuclear DNA in blue.

IF image of the rat spinal cord section stained with CPCA-IBA1 (red). Nuclear DNA in blue.