Introducing DART-HT = 96-well format Scanning with feedback loop control and improved sample positioning

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Everyone is under pressure to get answers.  We want to help!  At the meeting this year you can see our new  DART-HT system, it offers high speed sampling using  multi-dimension sample scanning system with improved sample positioning reliability.  If you have a burning desire to reduce your cost per analysis w e are looking for candidates for our validation program.

Interested in more rapid sample prep?  Then talk to us about our PARALLEL SPME technology for a start. We are working with Waterloo U., and MilliporeSigma to enable simultaneous solid phase extraction of up to 96 samples in under an hour? Start your meeting with Prof. Pawliszyn at  9:50 AM Monday, Development of Solid Phase Microextraction (SPME) Devices for Analysis of Drugs in Biofluids via DART

How about getting a report of a potential unknown from your IMS and then being able to get a mass spectrum using without changing your sample collection method? The  DART-TD for thermal desorption from SWABs enables  direct determination of chemicals desorbed from Morpho Systems  IMS sample SWAB in seconds per sample.  Add  DART-TD to your high resolution LC/MS or LC/MS/MS systems. Stop by booth #718 to discuss joining our
validation program.

TD module mounted positioned in the DART source ionization region

Ready for a Nightcap?

This year DART will be center stage in the WATERS CORP Hospitality Suite.  Check out the non-stop appearance of the DART/QDa to learn more about our exciting partnership.  For a highlight-reel of the utility of DART with mass detection click
thats right, forget the .com.  Interested in really at-the-reaction monitoring.  Join one of our focus groups.  Stop by the booth #718 to register!

Finally, check out the  ionRocket Temperature Gradient System  at Booth 821 for use with your DART®-SVP or OS.  Visit their posters or send an email with ionrocket in the subject line to

See you soon!

Best regards,

Brian Musselman, Ph.D.
President and CEO

Highlighted Publication

Rapid analysis of trace drugs and metabolites using a 
thermal desorption DART-MS configuration

National Institute of Standards and Technology, 
Materials Measurement Science Division, Gaithersburg, USA

The need to analyze trace narcotic samples rapidly for screening or confirmatory purposes is of increasing interest to the forensic, homeland security, and criminal justice sectors. This work presents a novel method for the detection and quantification of trace drugs and metabolites off of a swipe material using a thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS) configuration. A variation on traditional DART, this configuration allows for desorption of the sample into a confined tube, completely independent of the DART source, allowing for more efficient and thermally precise analysis of material present on a swipe. Over thirty trace samples of narcotics, metabolites, and cutting agents deposited onto swipes were rapidly differentiated using this methodology. The non-optimized method led to sensitivities ranging from single nanograms to hundreds of picograms. Direct comparison to traditional DART with a subset of the samples highlighted an improvement in sensitivity by a factor of twenty to thirty and an increase in reproducibility, measuring integrated area of the base peak, sample to sample from approximately 45% RSD to less than 15% RSD. Rapid extraction-less quantification was also possible.


About IonSense
IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. We manufacture and develop direct analysis in real time (DART ®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and ASAP Sources are available for most commercial LC/MS systems.   Look here to see if your system is DART-ready.  And    check here to see if your system is ASAP-ready.

For your local representative, please see our distributor network. 

Phone - 781.484.1043  | |