The prevalence of childhood overweight and obesity in the US has tripled over the past 3 decades. The comorbid conditions associated with obesity are numerous and deleterious for our nation’s children and their future. Genetic, environmental, and cultural inputs are contributing factors to childhood obesity. A recent study in JAMA Pediatrics including 900+ full-term infant-mother pairs to examine the plausibility and possible mechanisms mediating the intergenerational transfer of obesity from mother to offspring. The mediating roles of birth mode and infant gut microbiota composition were investigated.