July 2021
Tips to Maximize your Results with Respen-ATM
Welcome to our Respen-A newsletter, a way for us to share tips on how to maximize the benefits of the Respen-A, to feature upcoming events, and to introduce you to some of the people whose lives have been changed due to this Homeopathic Treatment! Please read on, and share...
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Elaine answers EVEN MORE of your questions:


When I first use Respen-A, is there a formula that can help me determine what the problem is if I am having issues ?

IF your son is hyper and happy = the dose of Respen-A is too high. Cut the disc in half and use as normal for 1 - 1 1/2 weeks while excess serotonin depletes, then go back to a full disc. You can return to full disc sooner if you see signs of depression.

IF your son is irritable and hyper with other autism symptoms (stimming) = the dose of Respen-A is too low OR your son needs more serotonin = give 100 mg of 5HTP 3 - 4 times per day- every 4 hours- or inositol (GLUTEN is preferable to inositol).

IF your son is irritable and aggressive but does not show other symptoms of autism = low calcium levels. He is either not absorbing calcium properly or, when using calcium lotion, user error has occurred...in which case he has not received enough calcium.


Does Elaine have anything for COMT? It's a neurotransmitter like MAO-A.

First, COMT is not a neurotransmitter, but an enzyme, and it is typically not the problem. It is a different mechanism entirely and it usually is working when the MAO-A isn't. It runs counter to MAO-A. That is, it does and it doesn't. Part of COMT goes down a pathway to the norepinephrine molecule. The other part goes down a pathway to the dopamine molecule. COMT methylates the ring on the molecules. That's about as far as I am going to take you with the science as it is kind of like trying to explain trigonometry to a 3 year-old. Could you have a problem with both COMT and MAO-A? Yes, it's possible, but you would be really, really sick!


Can we try the PST disc before the Respen-A? Our son has toxins that need to be cleared, like mold, and he might have better focus if we try PST.

As for detoxification, the MAO-A detoxes everything while PST is just one pathway. As for PST vs. Respen-A, some people respond better to the PST disc and you are welcome to try it.


Why have we seen such a drastic spike in Autism since 1996?

Why the rapid increase in ASD? I hypothesize that it is multi-factorial, but what sets up the “perfect storm” for the development of autism is the use of epidurals during childbirth coupled with inheriting the low activity MAO-A allele. Let me explain the basis of my hypothesis. 

MAO-A metabolizes serotonin into its active aldehyde, 5-HIAL. If MAO-A activity is decreased, the serotonin in the nerve synapses will build up, and increased serotonin concentrations in the nerve synapses inhibit oxytocin neuron growth. 
Note that studies have shown an increase risk of autism in the offspring of mothers who used antidepressants during their pregnancy. 

In utero, as the neurohypophyseal system grows it produces vasopressin which is converted to oxytocin as it travels down the neurohypophyseal plexus. The longer the neurohypophyseal system grows, the more oxytocin is produced. When the oxytocin reaches a specific concentration, it tells the neurohypophyseal plexus to stop growing. This is not supposed to happen until about 7-10 days postpartum. 
Note that research has shown that ASD patients have an immature neurohypophyseal plexus. 

When a mother receives an epidural during childbirth, almost always they are administered Pitocin (synthetic oxytocin) and this is usually continued through the delivery stage. The anesthetics used in the epidurals, Bupivacaine and more recently Ropivacaine, compete with Pitocin for breakdown by the Cytochrome p450 3A4 enzyme in the liver. 
Note that boys genetically have less of the Cyp450 3A4 enzyme than girls. 

This competition for the Cyp450 enzyme results in Pitocin remaining at higher levels longer, which could become high enough to trigger the neurohypophyseal system to stop growing, resulting in decreased oxytocin neuron growth and production. 

The use of epidurals and rate of autism mirrored each other until 1996 when autism spiked drastically. Interestingly, 1996 is when Ropivacaine came on the market and became the most used anesthetic in the epidurals. Ropivacaine requires twice as much Cyp450 3A4 enzyme activity to metabolize it as does Bupivacaine. 

Research shows that MAO-A is integral in the neurochemical architecture of the neurohypophyseal system. The hypothalamus-neurohypophyseal system is involved with releasing oxytocin during stress and to maintain homeostasis. 
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Did you know that we are offering 3 months of FREE RESPEN-A™?

How to get it: send us a before and after video of you or your child on Respen-A that we can post on our www.respen-a.com website under testimonials, and on our Facebook page.

This offer is valid WORLD-WIDE and includes the calcium/magnesium skin cream. Simply upload your video to YouTube or Vimeo, then send us the link at info@respen-a.com.

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What's it Like to Work With Elaine?

I've often told people that speaking with Elaine is like talking to a medical encyclopedia, if that were even possible! I volunteer my time to help her- as a conduit between patient and the answers sought- to give her the time and ability to do further research. After all, we have ALL benefitted from her brilliance! I listen, fully optimistic that I will be able to retain a sliver of what she says "as it travels in one ear and out the other". Sometimes I am able to glean enough to be able to share it with others. The following is from a letter that Elaine shared with me in 2017, and it is a perfect example of what speaking with her is like. Enjoy!


My company has been researching autism for the past twelve years, and we have had to self-fund this research. From this research, we developed the treatment, Respen-A, to treat the core symptoms of autism. I would also like to share what we have learned from our research.

We have found that the root of autism lies at the mitochondria, specifically deficient monoamine oxidase-A (MAO-A) activity. MAO-A is genetically expressed as a high or low activity allele on the X-chromosome. The low activity MAO-A allele has been shown to be associated with ASD. 

Those with a low activity allele are more susceptible to inhibition of the MAO-A activity by environmental factors. MAO-A activity is inhibited by stress, lipid peroxidation, high estrogen, heavy metals such as aluminum, mercury, cadmium and chronic high copper levels. 

There are two isoforms of MAO; MAO-A and MAO-B. MAO-A metabolizes histamine, serotonin and norepinephrine and MAO-B metabolizes dopamine. Interestingly, research in 1986 by Palmer et al has shown that these monoamine aldehyde metabolites are physiologically active. Thus, instead of the catecholamines and indoleamines being the active neurotransmitter, it is more likely that the aldehyde metabolites are the active agonist on the post synaptic receptors. 

MAO-A metabolizes; histamine into the active H2 agonist, telemethylimidazoleacetaldehyde; serotonin into its active aldehyde, 5-HIAL; and norepinephrine into its active aldehyde, DOPEGAL. Medicine has assumed that, for instance, low levels of the serotonin excreted metabolite, 5-HIAA in the urine indicates low serotonin levels, but research actually shows that 5-HIAA levels do not indicate serotonin concentrations but rather reflect MAO-A activity.
 
When the ratio of MAO-A:MAO-B is decreased it results in mitochondrial dysfunction by inhibiting the alpha-ketoglutarate dehydrogenase enzyme and the NADH dehydrogenase enzyme. Inhibition of the alpha-ketoglutarate dehydrogenase results in impaired Acetyl CoA production. This results in increased conversion of pyruvate to alanine. Increased alanine levels inhibit MAO-A activity. 

Inhibition of NADH dehydrogenase results in impaired transfer of electrons to the electron transport chain. Inhibited NADH dehydrogenase activity also results in decreased oxidation of NADH to NAD resulting in decreased superoxide ion production which is needed to pull the electrons down the electron transport chain. Inhibition of NADH dehydrogenase results in lactic acid production. Increased levels of lactic acid and the decreased oxygen consumption by the mitochondria can trigger the cell danger response. The increase in lactic acid results in increased calcium influx resulting in mast cell hypersensitivity, inflammation and cell destruction. This increase in calcium influx also explains the increased risk of seizures in the ASD population.
 
This scientific rationale is the basis for our development of the treatment, Respen-A. Respen-A is a homeopathic dilution of reserpine which has been shown to double the activity of MAO-A. Respen-A has been prescribed as a compounded treatment to over 900+ ASD patients with no adverse side effects. A small study of ASD patients (N=9), average age 13.5 years, showed significant improvement in ATEC scores (p<0.001) using the Respen-A for 3 months.

(Submitted by Kerri McCormick)
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IF YOU WOULD LIKE TO HAVE YOUR CHILD FEATURED IN A FUTURE NEWSLETTER, PLEASE LET US KNOW!
HAVE YOU HEARD?

Elaine is working on something new...sort of. She developed AM-4 many years ago and then set it aside. AM-4 stimulates the gene expression of MAO-A. It is used 1 day on 2 days off, which follows the MAO-A half-life- MAO-A lasts 3 days in the body before it's used up and gone. 

Recently, Elaine was able to do more research and discovered that the AM-4 inhibits the negative effects of alanine on MAO-A*.

AM--4 is currently being tested with PST, with Respen-A, and by itself to determine which will provide more gains in freeing people from the trap of autism. To date, the results look promising !
*(see #2 in Did You Know? below)
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DID YOU KNOW?

1. The calcium requirements are the same whether a full disc or a half disc is used.

2. Glutamine and alanine are the most abundant amino acids generally in the body, and both are associated with the MAO-B pathway. MAO-B is the counterbalance to MAO-A, and can decrease the activity of MAO-A. Glutamine and GABA may possibly increase MAO-B activity, therefore decreasing MAO-A activity. This action counteracts the Respen-A™ Disc's action of trying to boost MAO-A. Tyrosine shouldn’t be supplemented because it feeds the dopamine, which is too high in autism. For this reason Glutamine, Tyrosine and GABA should not be supplemented when using Respen-A
FREE one month supply of Respen-A to New Users!
Elaine is offering one month of Respen-A™, FREE to new users. This is a $50 savings!

We want every parent to experience the joy of recovering their child from autism, ADD/ADHD, anxiety, depression, bipolar disorder, and more, so tell your friends and people you know about this special offer!

You'll pay for shipping ($15 in the U.S., shipped USPS Priority Mail, other countries may cost more), and $10 for a one-month container of calcium/magnesium skin cream necessary to make the Respen-A work. Order ships upon payment.

Please help us help others by telling your friends about this opportunity to try Respen-A™ , FREE, and help us to change the face of autism! Tell them to send their request for this offer to Elaine at info@respen-a.com.

(Photo shown is Kyle, a happy Respen-A user!)

TOGETHER, WE CAN
CHANGE THE FACE OF AUTISM!
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Please stay tuned for our September 2021 Newsletter !
| MedDEV-OTC Inc. | 360-652-2816 | info@respen-a.com | www.respen-a.com