Topics, Trends & Updates

June 2026

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Updated Guidance: Addressing the Needs of Older Patients and Long-Term Survivors in HIV Care

The Guidance: Addressing the Needs of Older Patients and Long-Term Survivors in HIV Care was developed to present strategies to help clinicians recognize and address the needs of older populations with HIV or those who are long-term survivors of HIV.


Updates by author Dr. Eugenia L. Siegler and the MCCC include:


  • Updated discussion, references, and resources throughout guidance
  • Incorporated long-term and lifetime survivors with HIV as target patient population

Quick Links:

Full Guidance

Printable PDF

Updated: Mycoplasma genitalium Management in Adults

The Mycoplasma genitalium Management in Adults guideline was developed to address the care of adults with and without HIV who have acquired sexually transmitted M. genitalium infection.


Updates by author Dr. Daniela E. DiMarco and the MCCC include:


  • Global: Discussion and references updated throughout
  • Laboratory Testing and Diagnosis section: Pelvic inflammatory disease (PID) added to the following recommendation: Clinicians should test for M. genitalium in individuals with persistent or recurrent urethritis or cervicitis, or with PID. (B2)
  • Treatment section:
  • New recommendation: When managing M. genitalium treatment failure, clinicians should obtain macrolide resistance testing to guide antimicrobial selection. (A2)
  • New recommendation: For ongoing sex partners of individuals with symptomatic M. genitalium infection, clinicians should offer testing and treat those with positive M. genitalium test results. (B3)
  • Recommendation removed: When M. genitalium testing is unavailable, clinicians should treat patients when there is a high clinical index of suspicion for M. genitalium infection and other STIs have been reasonably excluded from the differential diagnosis. (B3)
  • Table 1 updated: Section removed on what to do if M. genitalium nucleic acid amplification testing is unavailable, as testing is now widely available

Quick Links:

Full Guideline

All Recommendations

Printable PDF

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Second-Line ART After Treatment Failure or for Regimen Simplification


Viremic—Cases in HIV Podcast

Join Hosts Eileen Scully and Christopher Hoffmann as they present cases, explore quandaries in adult HIV care, and discuss key evidence and guidelines that inform clinical decision-making.



New Episodes

Case 23. Managing Directly (Inter)Acting Medications: Chris presents a 62-year-old man with HIV for >30 years, with viral suppression and many drug resistance mutations, whose ART must be changed due to a drug-drug interaction, but also for simplification. As part of their discussion, Chris and Eileen review reasons to change ART regimens and work through the evidence-based options for this patient based on his history and resistance mutations profile. Listen Now

Case 24. A Violaceous Situation: Kaposi Sarcoma: A 42-year-old man with AIDS presents feeling unwell, with white spots in his mouth and scattered violaceous macules on his upper extremities; he has never taken ART. Listen as hosts Eileen Scully and Chris Hoffmann from Hopkins describe their initial work-up for a patient with a CD4 count of 10; discuss symptoms, diagnosis, and treatment of Kaposi sarcoma and other HHV8-related diseases; and remember the historical stigma of KS and the lingering effects of that stigma as they confirm the need to remain KS-aware even in 2026 in the United States. Listen Now

Coming Soon

Case 25. A Few of Our Favorite Vaccines: A new-to-you patient51-year-old man with HIV since the early 2000shas spotty vaccine records. How to educate, make recommendations, and avoid too many jabs at once so the patient comes back? Listen as Chris and Eileen from Johns Hopkins make the case for their favorite vaccines among the many recommended for adults with HIV and describe their approaches to patient education, prioritizing based on specific patient needs, and strategizing vaccination schedules. Listen June 23

Viremic will be on summer hiatus during July. Catch up on missed cases before we return in August with a brand-new season!

We’re open to suggestions! To submit a clinical topic for a Viremic case discussion, email us at viremicpodcast@jh.edu.

Conversations With CEI Podcast

ASSETS-NY—Anal Dysplasia Screening, Surveillance, Education and Treatment Services of New York: Host Marguerite Urban, MD, is joined by William DeWitt, MD, Clinical Director of Anal Health in Primary Care at Northwell Health, to discuss a new coalition forming in New York City about anal dysplasia. ASSETS-NY aims to bring together people in this field and harness momentum to drive further research and implementation of anal dysplasia and cancer screening, surveillance, education, and treatment in New York State. Be sure to check out the coalition’s website at https://www.screenyourbutt.org/nyc/. Listen Now


Introducing Point-of-Care Testing for Hepatitis C: New York State’s Hepatitis C Dashboard shows that in 2023, 4,783 people were newly diagnosed with HCV in the state, an 8% decrease from 2022. Incidence also decreased, with the rate of new HCV infections dropping from 4.0 to 3.6 per 100,000 population among adult New Yorkers. Despite these gains, progress towards elimination has been stalled by reliance on a multi-step diagnostic algorithm to confirm viremia. In populations with the highest risk of infection—including people who inject drugs—testing and treatment are often inaccessible due to barriers along the care cascade. On June 27, 2024, the U.S. Food and Drug Administration authorized the first point-of-care (POC) HCV RNA test that can be performed where a person receives care, like an outpatient clinic or mobile unit. The availability of POC HCV RNA testing, which can provide qualitative results in 60 minutes, unlocks New York’s ability to integrate a test-and-treat approach where a person can be tested for HCV, and if positive for HCV RNA, be linked to care and potentially receive treatment during the same health care visit. To achieve elimination goals, simplified care that engages people who inject drugs is essential, and single-encounter testing and treatment offers a new tool to significantly expand access, decrease time from diagnosis to treatment, and increase the number of New Yorkers who are treated for HCV. Today’s episode will focus on this new diagnostic tool and its potential impact on HCV elimination across New York. Listen Now


Cannabis and Pregnancy: Based on data from 2023-24, roughly 23% of New Yorkers aged 21 or older reported cannabis use in the past 12 months. Although men generally have a higher prevalence of use than women, recent studies show a narrowing gap as female consumption rises. Despite this trend, research is sorely lacking on the impact of cannabis use on pregnancy, birth outcomes, and overall health. Many advisory panels and organizations advise against the use of cannabis during pregnancy, but there are numerous reasons pregnant people choose to use. On today’s episode, we’ll talk through the evidence and provide best practices for caring for pregnant persons who use cannabis. Listen Now


CROI 2026—Live from Denver: What You Need to Know: The Conference on Retroviruses and Opportunistic Infections (CROI) 2026 took place from February 22 to 25 in Denver, Colorado. CROI is an annual scientific meeting devoted to the understanding, prevention, and treatment of HIV/AIDS and the opportunistic infections associated with AIDS. Thousands of leading researchers and clinicians from around the world convene each year for the conference. On this episode, Antonio Urbina, MD, Medical Director for CEI’s HIV Primary Care and Prevention Center of Excellence, reflects on this year’s conference and shares his highlights about exciting developments in the world of HIV prevention and treatment. Listen Now

Upcoming Training, Education, and Events

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