LDA NEWS & UPDATES 

June 29, 2023

ATTENTION! GOOD NEWS!


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LDA-Columbia University CME Lyme & TBD Conference

 

Virtual, October 13,14, 2023

 

Limited Medical scholarships available

A Review: Seeking a Cure for Lyme Disease

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Advancing Understanding of PTLD

Frontiers in Medicine (Adkison, H., et al.) 5.24.23 published “Lyme disease and the pursuit of a clinical cure.” The review addresses mechanisms that are validated or challenged by the scientific evidence (in vitro, in vivo, and clinical) with a particular focus on the role of immune response and resolution of Borrelia spp. infections in humans. Also discussed are the next generation of treatments aimed at establishing biomarkers that will predict both treatment responses and outcomes. Read more.

Lyme Presenting as Complete Heart Block in Young Man

Case Report and Review of Pathogenesis

IDCases (Carnazzo M. C., et al.) 2023, published “Lyme disease presenting as complete heart block in a young man: Case report and review of pathogenesis.” The case report focuses on a young man with complete heart block due to Lyme carditis, a rare complication of Lyme disease primarily affecting young adults, with men being more affected than women by a 3:1 ratio. Read more.

Read case report.

Powassan Virus Persistence After Acute Infection

Powassan Virus; Credit: Canad. Med Assn.


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A Severe Tickborne Virus 

American Society for Microbiology Journal (Telford S. R., et al.) 06.20.2023, published “Powassan virus persistence after acute infection.” This study aimed to better understand the lasting neurological effects of Powassan encephalitis by observing the effects of Powassan virus (POWV) in mice. Powassan encephalitis is a severe tickborne virus with a high mortality rate and lasting symptoms in many individuals after recovery. Read more.

Seroprevalence of Tick-Borne Infections in German Horses

Bb sensu lato and Anaplasma phagocytophilum

Animals (Gehlen H., et al.) 06.10.2023, published “Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses.” The study aimed to gain further knowledge on Lyme borreliosis in horses due to limited data in the field. Samples were taken from horses suspected of having Lyme borreliosis as well as healthy horses and then tested for antibodies. Results showed 23% of the suspected horses and 17% of the healthy horses were positive for Borrelia burgorferi sensu lato infection. Read more.

Bb in mouse; credit Stephen W. Barthold, DVM, PhD

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Diversification of Bourbon Virus in New York State

Bourbon virus


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Tick-Borne Virus Spreading Farther East

Microorganisms (Lange, R. E., et al.) 06.12.2023, published “Diversification of Bourbon Virus in New York State.” Researchers worked to clarify the genetic characteristics of Bourbon virus (BRBV) strains from the state of New York. The study identified two different strains of BRBV in New York State and suggests that these strains could “contribute to increased spread of BRBV in the northeastern US.” Read more.

A Case Report: Tick-Borne Myopericarditis

Positive Anaplasma, Lyme, and Epstein Barr Virus

Cureus (Arshad, H., et al.) 06.14.2023, published “Tick-Borne Myopericarditis With Positive Anaplasma, Lyme, and Epstein Barr Virus (EBV) Serology: A Case Report.” The report focuses on a 61-year-old male who was unknowingly presenting with myopericarditis symptoms for two weeks, which can occur in some Lyme carditis cases. The symptoms eventually led to septic shock. After furthered investigation, it was discovered that the individual had a recent tick exposure which prompted a change in treatment and proved successful. Read more.

Read the report.

A Variable in Persistent Lyme Disease: Biological Sex

Data Shows Key Differences

International Journal of General Medicine (Johnson, L., et al.) 6.17.23, published “Does Biological Sex Matter in Lyme Disease? The Need for Sex-Disaggregated Data in Persistent Illness.” In this study researchers examined the outcome differences between men and women with Lyme disease. Investigators analyzed self-reported clinical data from 2170 patients in the MyLymeData patient registry, as well as review of other Lyme disease studies. Read more.

Read the study.

Potential Biomarkers for Neuro Lyme

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Observing Cytokine and Chemokine Levels

Scientific Reports (Gyllemark, P., et al.) 6.15.23, published “Intrathecal Th17-driven inflammation is associated with prolonged post-treatment convalescence for patients with Lyme neuroborreliosis.” In this study, researchers investigated the forces of identified cytokines and chemokines that are responsible for inflammatory response during Lyme neuroborreliosis (LNB) to identify potential biomarkers for this inflammatory activity. Read more.

Permethrin-Treated Uniforms Increase Tick Bite Protection

MilTICK Study

The Army (Douglas Holl, Defense Centers for Public Health-Aberdeen Public Affairs) 5.31.23, published a study by Department of Defense (DOD) Military Tick Identification/Infection Confirmation Kit Program (MilTICK program) on the effectiveness of permethrin-treated uniforms against ticks. Ticks submitted by service members wearing permethrin-treated uniforms were much less likely to have become engorged. The program is open to active-duty service members, DOD beneficiaries, contractors and civilians, and has been offering free identification and analysis of ticks that have been removed from human patients for 20 years. Read more.

More information.

Chronic Wasting Disease: Transmission by Ticks

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Fatal Outcomes

Scientific Reports (Inzalaco, H.N., et al.) published 5.15.23 “Ticks harbor and excrete chronic wasting disease prions.” This study investigated the role ticks play in the transmission of chronic wasting disease (CWD) in members of the deer family (cervids). CWD

is a neurodegenerative disease caused by infectious prions (misfolded proteins) that result in a slow but progressive and fatal outcome for both domestic and wild cervids that are exposed. Both direct and indirect routes of exposure and transmission are found to contribute to increase of prevalence and geographic spread of CWD. Read more.

FDA Approves Paxlovid as COVID-19 Antiviral Treatment

For Management of Mild to Moderate Infections 

JAMA (Harris, E.) 6.7.23, published “FDA Grants Full Approval to Paxlovid, COVID-19 Antiviral Treatment.” The article provides a summary of the FDA’s recent approval of the oral drug, Paxlovid. Read more.

Read announcement.

LDA Approved National Charity By CFC 2023

Visit CFC website.

18 Years Running

The Lyme Disease Association, Inc. (LDA) has been approved as a national charity by the Combined Federal Campaign (CFC) 2023. This designation means inclusion in the 2023 Combined Federal Campaign (CFC) National/International Charity List. CFC is part of the federal Office of Personnel Management (OPM). Each

year, federal employees are provided with lists of approved charities for their workplace giving through the CFC. The LDA has applied for, met the requirements and been a part of CFC for 18 years running. LDA’s administrative and fundraising rate (AFR) was determined by CFC to be only 3%, the percentage of dollars spent on expenses other than services. Read more.

Persistent Symptoms after Lyme Neuroborreliosis

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Association with Increased Levels of Interferon-α

Emerging Infectious Diseases (Hernández, S., et al.) 06.2023, published “Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood.” The purpose of the study was to determine the cause of persistent, lingering symptoms of Lyme neuroborreliosis (LNB), despite antibiotic drug treatments. Read more.

National Academies Infection Associated Illnesses

Workshop Included Lyme & COVID

The National Academies of Science, Engineering and Medicine (NASEM) hosted a groundbreaking workshop “Toward a Common Research Agenda in Infection – Associated Chronic Illnesses: A Workshop to Examine Common, Overlapping Clinical and Biological Factors,” on June 29 – 30, in Washington DC. Registrants attended in-person and virtually. Read more.

Visit NASEM website.

Lyme Innovations Co-Creation Workshop

Collaborating to Advance the Field

An free online workshop co-sponsored by Health and Human Services (HHS) Office of the Assistant Secretary for Health (OASH) and The Center for Open Data Enterprise (CODE) took place on June 28, 2023 from 2-4pm ET. The workshop included diverse partners who are connecting to advance the field. Lyme Innovation is an HHS patient-centered approach to Lyme and tick-borne diseases. Read more.

More information.

The Lyme Disease Association Inc. (LDA) does not charge any membership fees. Most of our

materials are free to download and most of our videos are free on YouTube. Our nationwide

doctor referral system is free to access. Printed brochures can be ordered for the cost of S&H.  

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CFC 2017 Approves LDA as National Charity
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