We know that membrane protein, a class of proteins that are embedded in the phospholipid bilayer of cell membranes to enable extracellular and intracellular spanning, occupies a place in the field of 'non-pharmacological' therapeutics. Many human diseases may be associated with abnormal receptor function, and the multifunctional nature of receptors makes them ideal targets for drug action. However, multi-pass receptors are structurally complex and often expressed at extremely low levels in the host cell. The use of high-quality, full-length transmembrane receptors is therefore essential for the accurate characterization of drug candidates. High-throughput surface plasmon resonance (HT-SPR) is a powerful technique that is transforming the characterization workflow, enabling greater breadth and depth of information on up to thousands of drug candidates.