Neuroscience Update
September 2019
  
Welcome to Scitech's Neuroscience newsletter.
The main focus of this newsletter is to introduce new products and technologies relevant to Neuroscience Research.  
 
Scitech will be exhibiting at the ANS 2019 conference at the Adelaide Convention Centre, Adelaide from 2-5 Dec 2019. Please visit us to see some of the latest technologies and how they are designed to help facilitate your neuroscience research. 
      
 
Scientifica has  developed premium scientific equipment to enhance the research of neurons, neuronal circuits and animal behaviour. The product range has expanded to include high quality, cost-effective instruments for applications in electrophysiology, patch clamp, multiphoton imaging and optogenetics studies.
 
Products include:-  
  • Electrophysiology rigs
  • Multi Photon Imaging
  • Optogenetics and Uncaging
  • Manipulators
  • Microscopes
  • Stages and Platforms
  • Control Options
  • Perfusion
  • Temperature Control    
 Scientifica product range brochure: Click to see a summary of their products  


 
 
Blackrock Microsystems focuses on helping researchers achieve excellence in neuroscience, neural engineering, ephys research and neural prosthetics. Blackrock products and setups rate as the most user-friendly in the industry, while offering high quality, reliable data and simple, intuitive operation.
 
Major product categories include:-
  • DAQ systems including Cerebus, NeuroPort and Cereplex direct
  • Stimulation systems -  CereStim 96
  • Ephys electrodes - Utah Array, Utah Slant Array, Utah Rodent Array, Neuroport Array, Microflex Array
  • Headstages - Analogue and Digital
  • Ephys adapters
  • Behavioural systems - Video tracking, Virtual Reality Jetball, qOMR
  • Analysis software - BOSS, NeuroExplorer and MATLAB
  • Rigs & setups directly tailored to your needs
 

      
 
The HT-2 series opens a new era of 3D correlative imaging, and is the world's first microscopy unit to effectively combine holotomography and 3D fluorescence imaging. Capable of simultaneously capturing high-resolution 3D optical diffraction tomography and 3D fluorescence images, the microscope enables long-term tracking of specific targets in live cells while minimising stress.
 
Ground-breaking research was recently undertaken by Tomocube Inc. and the Korea Advanced Institute of Science and Technology (KAIST) using the HT-2 microscope to explore the 4D interaction dynamics of T cells and their targets in the immunological synapse for the first time.


 
 
Neurolucida 360 studio has been recalibrated to provide a more in-depth analysis of varicosities. Tracing algorithms have been optimised to more accurately model varicosities and generated metrics such as maximum diameter, length, thickness ratio, distance to root, distance along branch, surface area etc. Users can also generate reports based on what structure (e.g. dendrite or axon) the varicosity is associated.
 
Key Features:
  • New 'Neurolucida360 Explorer' functionality allows users to perform extensive morphometric analysis on neuron reconstructions, serial section reconstructions and brain maps
  • Visualise and analyse data in a 3D environment while exploring specific quantitative measurements
  • New '3D Movie Mode' to easily create and edit dynamic presentations of reconstructions
  • New 'Large Volume Reconstruction Mode' to optimise the user's ability to reconstruct sub volumes of extremely large datasets
  • Hundreds of Quantitative Analyses: Customise many of the analyses to address your specific research questions
  • Results are easily exportable to most statistical and spreadsheet software for analysis
  
 
     
 
The BioCAM DupleX from 3Brain is a fully bi-directional microelectrode array platform for 2D and 3D in vitro electrophysiology. Its bidirectional capabilities allow researchers to simultaneously record high-density electrophysiological data at 18 kHz and induce electrical stimulation at any of the 4,096 microelectrodes. In addition to this micrometre-precise electrical stimulation, active and passive light shielding allows the use of ontogenetic tools without affecting chip functionality.
 
Key Features:
  • 4096 stimulation sites 
  • 4 differential channels (accessible with optional connector box)
  • 12 bit data resolution
  • Computational Core: Intel®'s Arria® 10 FPGA 13Gbps, 2GB DDR4, and ARM® dual-core Cortex™-A9 1.5 GHz
  • Data Interface: USB 3.1 Type-C
  • Dimensions and Weight: 180 x 230 x 40 mm, 2 Kg

             
   
The Polygon1000 from Mightex provides the same features and reliability as the Polygon400 (currently used in 300+ labs worldwide and published within 35+ publications), however has improved design for more intricate photo stimulation experiments.
 
Key Features:
  • 1 million pixel count
  • 4ms loading frame time enabling virtual real-time pattern illumination for closed-loop experiments
  • 6600 fps compared to 4000 fps, means enhanced temporal resolution for advanced physiologically relevant experiments and virtual simultaneous 2-colour illumination of distinct ROIs
  • Larger DMD chip
  • 45% increased power-density at sample level
  • UV to visible range illumination
  • Interchangeable front tube optics enabling better trade-off between FoV and spatial resolution


 
 
 
The Crest Optics X Light V3 is the next generation of X-Light spinning disk confocal head series. Integrating cutting-edge technology, it has been engineered to meet the high-end specifications of modern fluorescence microscopy applications. It is the first confocal unit to allow for dual camera imaging at the full field of view of 25mm on both cameras.     
 
                                    
Key Features: 
  • 400-750nm spectral range
  • Fastest spinning disk with 15.000 rpm rotation speed, up to kHz range
  • Ultra-large field of view imaging: maximum 25 m
  • Lateral resolution (FWHM): ~ 230nm (High NA 1.4) diffraction limited
  • Dual-camera view: simultaneous dual-camera view up to 25 mm each camera
  • Axial resolution (FWHM): ~600 nm (High NA 1.4)
  • User inspired: Customise pinhole size and geometry
Supported Software solutions: Metamorph, Nis-Elements, Micromanager, Volocity and Visiview
 
 

   

 
The pco.edge 4.2 bi is a back illuminated camera sensor with high resolution and a 6.5 x 6.5 μm² pixel size for high-quality images with quantum efficiency up to 95%. It incorporates a powerful USB 3.1 interface, and a flexible cooling system allowing the use of air or water to cool the sensor down to -25 °C. At this temperature, the dark current is reduced to 0.2 e-/pixel/s. 
 
Key Features:
  • Back illuminated
  • 16bit sCMOS sensor technology
  • Up to 95 % quantum efficiency
  • Down to -25°C adjustable cooling
  • 2048 x 2048 pixel resolution
  • 40 fps maximum frame rate
  • exposure times from 10μs to 20s
  • UV or VIS input window
  • USB 3.1 Gen1
   
 

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and New Zealand since 1989
 
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