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December Lawson LEADS publications
Select articles published by Lawson scientists Oct. 28 – Nov. 24, 2025:
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Free to access full text:
The following research articles are free for the public to access. You can view a copy of the research by clicking on the title.
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Salbach N, Jones CA, Barclay R, Sveistrup H, Sheehy L, Bayley M, Inness E, Legasto-Mulvale M, dos Santos RB, Fung J, Moineddin R, Teasell RW, Jaglal SB, Catizzone M, Hovanec N, Cameron J, Munce S, O’Neil J, Jaglal SB, Aravind G, Su T, Hanson HM. (2025). Short-term effects of a virtual, community-based, task-oriented group exercise program compared to a waitlist control in increasing function among adults with balance and mobility limitations: Protocol for the TIMETM at Home randomized controlled trial. BMJ Open.
Can online group exercise improve balance and mobility? This research trail tests a virtual, task-oriented program for adults with movement challenges. Researchers will compare participants to a waitlist group to see if short-term gains in strength and confidence occur. Why is this important? Mobility limitations affect independence and increase fall risk. If successful, this program could make rehab more accessible for those unable to attend in-person classes. Clinicians, physiotherapists and community health planners should read this paper to learn how transform rehabilitation delivery using virtual care.
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Aronson R, Abitbol A, Bajaj HS, Cheng AYY, Christopoulos S, Harris SB, Jain AB, Goldenberg RM. (2025). Continuous glucose monitoring in noninsulin-treated type 2 diabetes: A critical review of reported trials with an updated systematic review and meta-analysis of randomised controlled trials. Diabetes, Obesity and Metabolism.
Hanna A, Armstrong JJ, Kiatos-Tsioros E, Rocha G, Hutnik CML, Ahmed IIK. (2025). Reply: Intravenous vs nonintravenous sedation for cataract surgery: Systematic review and meta-analysis. Journal of Cataract & Refractive Surgery.
Chatto M, Alaskar D, Ma C, Yuan Y, Vuyyuru SK, Bessissow T, Narula N, Danese S, Peyrin-Biroulet L, Singh S, Jairath V, Sedano R. (2025). Pharmacological management of upper gastrointestinal Crohn's disease: A systematic review. Journal of Crohn's and Colitis.
Klingebiel FK, Oertel MF, Kalbas Y, Balogh ZJ, Beeres FJP, Coimbra R, Fang C, Giannoudis PV, Hietbrink F, Hildebrand F, Kurihara H, Lustenberger T, Marzi I, Peralta R, Rajasekaran S, Schemitsch EH, Vallier HA, Zelle BA, Pape HC, Pfeifer R; IMPACT group - International MultidisciPlinAry Consensus panel on polyTrauma. (2025). Timing of definitive fracture fixation in patients with concomitant traumatic brain injuries - A systematic review of the literature by the IMPACT group. European Journal of Trauma and Emergency Surgery.
Sheedy SP, Arya S, Baheti AD, Chang KJ, Gollub MJ, El Homsi M, Kassam Z, Khatri G, Kim DH, Lalani T, Lee S, Nougaret S, Paroder V, Rauch GM, Wasnik AP, Weiser MR, Horvat N. (2025). SAR Disease-focused Panel: Restaging rectal cancer MRI synoptic report-user guide with imaging review. Radiographics.
Steele N, Hussain A, Baird CL, Haswell CC, Sun D, ..., Lanius R, ..., Théberge J, ..., Morey RA. (2025). Volumetric differences of thalamic nuclei are associated with post-trauma psychopathology. Biology Psychiatry: Cognitive Neuroscience and Neuroimaging.
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Terry AL, Meredith L, Graham J, Law E, Sibbald SL, Trusler A, Thind A. (2025). Evaluating the impact of an integrated community care model for older adults. International Journal of Integrated Care.
How can we better support seniors living in the community? This study evaluates an integrated care model program combining home and community services over a two-year period in Sarnia and Lambton County. Researchers measured outcomes like hospital visits, quality of life and patient satisfaction to assess the implementation and effect of the program. The researchers found providers overcame challenges by aligning shared goals, forming new partnerships and creating community-based initiatives. Socially isolated older adults benefited from integrated services, while a supportive network of providers and system planners enhanced capacity to meet community needs. Health administrators, family physicians and policy makers interested in reducing costs and supporting older adults should read this paper.
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Chatto M, Sedano R, Jairath V. (2025). Gastric and duodenal mucosal healing with risankizumab in upper gastrointestinal Crohn's disease. ACG Case Reports Journal.
Basilious A, Yuan AT, Sheidow TG. (2025). Outcomes of 16-week extension of anti-VEGF therapy in neovascular age-related macular degeneration. Canadian Journal of Ophthalmology.
Kudva YC, Raghinaru D, Lum JW, Graham TE, Liljenquist D, ..., Spaic T, ...; 2IQP Study Group. (2025). A randomized trial of automated insulin delivery in type 2 diabetes. Obstetrical and Gynecological Survey.
Avinashi V, Gupta M, Payne BA, Amhaz H, Temirova AT, ..., Jeimy S, ..., Chan ES. (2025). Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: A Delphi consensus project. Allergy, Asthma and Clinical Immunology.
Solitano V, Hogan M, Singh S, Danese S, Peyrin-Biroulet L, ..., Sedano R, ..., Jairath V. (2025). Placebo rates in randomized clinical trials of ulcerative colitis: An individual patient data meta-analysis. Journal of Crohn's and Colitis.
Itkyal VS, Iraji A, Jensen KM, LaGrow TJ, Duda M, ..., Osuch EA, Theberge J, ...,
Calhoun VD. (2025). Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates. Network Neuroscience.
Kay K, Metersky K, Correia RH, Astell A, McGrath C, Sun W, Yurkiv H, Smye V. (2025). Establishing a dementia care competency framework for care partners, health and social care providers: A modified Delphi study protocol. PLOS ONE.
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Jeimy S, Huan PW, Abrams E. (2025). Management of anaphylaxis. Canadian Medical Association Journal.
Anaphylaxis is a severe allergic reaction that can be life-threatening. Delays in care can be fatal, yet many patients and providers remain uncertain about protocols. This article reviews best practices for rapid recognition and treatment, including the critical role of epinephrine. The guidance emphasizes education for clinicians and patients to ensure timely response. Emergency teams, primary care providers, educators and those with severe allergies should read this paper to learn more about best practices and develop clear actions plans that save lives.
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Mueller ME, Nichols ES, Al-Saoud S, de Vrijer B, McKenzie CA, Eagleson R, de Ribaupierre S, Duerden EG. (2025). Age-related changes in the amygdala from in utero to early childhood: association with social and cognitive outcomes. Human Brain Mapping.
Sampsell K, Marcolla CS, Tapping S, Fan Y, Sánchez-Lafuente CL, Willing BP, Reimer RA, Burton JP. (2025). Current research in fermented foods: Bridging tradition and science. Advances in Nutrition.
Burford JS, Booth RG, McIntyre A. (2025). Exploring the intersection of nursing leadership and artificial intelligence: Scoping review. JMIR Nursing.
Yau K, Ray JG, Jeyakumar N, Luo B, Abdullah S, ..., Clemens KK, ..., Wald R. (2025). Glucagon-like peptide-1 receptor agonists and risk of major adverse cardiovascular events in patients with CKD. American Journal of Kidney Diseases.
Rodrigues R, Edwards J, Madakadze C, Booth R, Archie S, MacDougall AG, Palaniyappan L, Cheng C, Chan S, Nagy K, Anderson KK; project co‐investigators. (2025). Barriers and opportunities for collaboration with primary care: Perspectives of early psychosis intervention programs in Ontario, Canada. Early Intervention in Psychiatry.
Tucker S, Heneghan NR, Gardner A, Rushton AB, Russell E, Soundy A. (2025). Protocol for a virtual nominal group technique to develop expert consensus on graded return to sports, exercise and physical activity during intermediate and late-phase rehabilitation following spinal fusion in AIS. BMJ Open.
So I, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, ..., Finger EC; Frontotemporal Dementia Prevention Initiative (FPI) Investigators. (2025). Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences. Journal of Alzheimer's Disease.
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Philip G, Fiocco AJ, Belleville S, Chertkow H, Feldman HH, Montero-Odasso M, Nygaard HB, Savundranayagam MY; Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN-THUMBS UP Study Group. (2025). Exploring the usability and perceived benefits of Brain Health PRO: An online educational program for healthy brain aging. Digital Health.
Can an online program help people maintain brain health as they age? Researchers explored the usability and benefits of Brain Health Pro, a digital tool offering education and strategics for cognitive wellness. Participants reported positive experiences and felt empowered to take preventive steps. As dementia risk is rising, clinicians, caregivers and older adults should read this paper to learn about accessible education option and how digital tools can complement traditional care.
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Middlebrook N, Heneghan NR, Moffatt M, Silvester L, Falla D, Rushton AB, Soundy A. (2025). Lived experiences of recovery following musculoskeletal trauma 6 months following injury in the UK: A qualitative study. BMJ Open.
Levy CJ, Kanapka L, Brown SA, Marks S, Spaic T, Steenkamp DW, Lu VS, Zhao P, Lum JW, Beck RW, Pinsker JE; 2IQP Study Group. (2025). Simplified meal bolus strategies with Control-IQ+ automated insulin delivery are safe and effective in adults with type 2 diabetes. Diabetes Technology & Therapeutics.
Thompson K, Vigeh AV, Rosha S, Dunne BJ, Henein E, Antony D, Terry AL. (2025). Virtual house calls: Using digital health technology for populations in assisted living. Canadian Family Physician.
Asghar M, Pang KP, Rotenberg B. (2025). Systematic review on the safety of outpatient upper airway surgery for obstructive sleep apnea patients in ambulatory surgical centers. Journal of Otolaryngology - Head and Neck Surgery.
Bysice A, Gibson R, Moore C, Sommer DD, Nichols A, Arts E, Sowerby L. (2025). Evaluation for the presence of SARS-CoV-2 in CO2 laser plume. Journal of Otolaryngology - Head and Neck Surgery.
Nassar E-L, Wurz A, Carrier M-E, Golberg M, Adams C, ..., Pope J, ..., Baril G. (2025). Protocol for a two-arm parallel randomized controlled trial to evaluate patient and researcher co-presentation of research results: The Scleroderma Patient-centered Intervention Network—Patients Alongside Investigators in Research-Sharing (SPIN-PAIRS) trial. Trials.
Hill JLE, Hill TG, Parslow D, Hill DJ. (2025). Pancreatic cancer and diabetes: insights, hypotheses, and next steps. International Journal of Molecular Sciences.
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MacDermid JC, Killip SC, Brazil A, Lomotan M, Fraser S, Bryant D, Cramm H, Nicholas Carleton RN. (2026). Adaptation, implementation, and evaluation of a protective mental health intervention (Resilient minds) for Canadian volunteer firefighters. Comprehensive Psychiatry.
Volunteer firefighters face intense stress and trauma. This study adapted and tested “Resilient Minds” a mental health program designed to build coping skills and reduce burnout. Researchers found strong levels of volunteer engagement and potential benefits for well-being. Fire departments, mental health professionals and those interested in the well-being of volunteer firefighters should read this paper to learn about proactive programs that can protect those protecting the community.
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Lechien JR, Vaira LA, Lamoulen L, Sowerby L, Radulesco T,..., Briganti G. (2025). Validity and reliability of the French Olfactory Disorders Questionnaire-10. Journal of Otolaryngology - Head and Neck Surgery.
Ruiz-Garcia R, Matías-Guiu JA, Grasso S, Ruiz-Rodríguez O, Medina-Rioja R, Finger E, Pérez-Neri I. (2024). Clinical tools accuracy for classification of primary progressive aphasia: A systematic review protocol; Precisión de las herramientas clínicas para clasificación de la afasia progresiva primaria: Protocolo de revisión sistemática. Archivos de Neurociencias.
Lieberman JM, Lanius R, Densmore M, Théberge J, Rabellino D, Frewen PA, Scharnowski F, Jetly R, Frey BN, Hosseiny F, Ros T, Nicholson AA. (2025). Contributions of the default mode and central executive networks during posterior cingulate cortex-targeted fMRI neurofeedback in PTSD. NeuroImage: Clinical.
Hur L, Islam A, Penny JD, Dorie J, McIntyre CW. (2025). Coronary artery disease and intradialytic myocardial ischemia in hemodialysis: An exploratory study using intradialytic imaging. Kidney Medicine.
Osifeso TA, MacDermid JC, Berinyuy D, Szekeres M, Parikh P, Faber KJ. (2025). Exploring the challenges and impact of work-related shoulder disorders on North American firefighters: An interpretive description. Discover public health.
Yang S, Berto FG, Denstedt J, Tang H, Zhang J. (2024). Point-of-care Urinary Tract Infection (UTI) diagnosis enhanced by nanostructured biosensors: Review paper. Advanced Sensor Research.
Bartlett S, Schieir O, Valois M-F, Boire G, Tin D, Pope J, ..., Zummer M. (2025). Predictors of depression trajectories during the COVID-19 pandemic in adults with rheumatoid arthritis: Results from the Canadian Early Arthritis Cohort. Rheumatology Advances in Practice.
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Perlman CM, Martin L, Elliott J. (2025). Inspiring that EUREKA moment: The Importance of patient co-design of outputs from interRAI assessments. Healthcare Management Forum.
How can patient voices improve care tools? This research study explored how involving patients in designing outputs from interRAI assessments can improve care planning. Using a co-design approach, researchers worked with patients and caregivers to create reports that are clear, actionable and person centered. Findings show that patient input enhances usability, supports shared decision-making and fosters better engagement in care. Health administrators, clinicians and patient advocates may find this paper provides valuable insights on collaborating with patients and caregivers for meaningful, patient-centered care.
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Makhzoum J-P, Mendel A, Touati A, Marcotte G, Barra L, Pagnoux C. (2025). Sonographic Assessment of the Optic Nerve Sheath in Giant Cell Arteritis (SONIC-GCA): Protocol for a prospective, multicentre diagnostic test accuracy study. BMJ Open.
Soskic S, Tregidgo HFJ, Todd EG, Bouzigues A, Cash D, ..., Finger E, ..., Lemos J. (2025). Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: A GENFI study. Brain Communications.
Fernandez-Ruiz J, Riek HC, Brien DC, Coe BC, Grimes DA, ..., Borrie M, B..., Montero-Odasso M, ..., Munoz DP. (2025). The relation of eye movements to the occurrence of freezing of gait in Parkinson's disease. Brain Communications.
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Pay to access full text:
The following research articles are not free for the public to access. You must purchase a copy of the article or a subscription to the journal to read about the research. Alternatively, you may be able to request a copy of the article through the library at St. Joseph's or Western University via institutional subscription or by contacting the highlighted scientist.
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Dhanvantari S, Dean ED. (2025). Glucagon, the alpha cell, and potential targets for diabetes treatment. Endocrinology.
When we think about diabetes, insulin often takes center stage, but another hormone, glucagon, is stepping into the spotlight. Researchers explored how glucagon, produced by alpha cells in the pancreas plays a critical role in blood sugar regulation by doing a mini review of other research studies. Their review highlights emerging therapies aimed at modulating glucagon activity to improve glucose control. These strategies could complement existing treatments and offer new hope for people living with diabetes.
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Peters S, Graham LJ. (2025). Closing the gap by exploring advances in neurorehabilitation physiotherapy research: A special issue introduction. NeuroRehabilitation.
Ratzki-Leewing A, Black JE, Bhatti J, Ryan BL, Zou G, Lin YK, Huang SJ, McCoy RG, Harris SB. (2026). Real-world incidence and risk factors of level 3 (severe) hypoglycaemia in adults with type 1 or 2 diabetes (iNPHORM, United States). Diabetes, Obesity and Metabolism.
El Chamaa A, Kowalski K, Begum R, Parikh P, Rushton A. (2025). Patients' experiences with musculoskeletal spinal pain: a qualitative systematic review. European Spine Journal.
Khoury S, Aleksa E, Smith C, Gandhi K, Ferreira L, Moore C. (2025). Donor site closure in paramedian forehead flap reconstruction: Impact on scar quality and patient satisfaction. Journal of Craniofacial Surgery.
Maniaci A, Lentini M, Lechien JR, Iannella G, Casale M, Moffa A, Pelucchi S, Caranti A, Pang KP, Rotenberg B, Vicini C. (2025). Head-of-bed elevation outcomes on apnea severity nasal resistance in obstructive sleep apnea: a multicenter observational study. Sleep and Breathing.
Rodrigues JFR, Rodrigues LP, Behera C, Rodriguez MFS, Sunkel R, Faveri LA, Heisel MJ, Rafnsson SB, de Godoy MF, Filho GMA. (2025). Suicidal behavior comorbidities in old adults: A systematic review and meta-analysis. Psychiatry Research.
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Mehrabi S, Flores-Sandoval C, Bateman EA, MacKenzie H, Billias N, Teasell R. (2025). Non-pharmacological complementary and alternative medicine therapies in randomized controlled trials of moderate to severe traumatic brain injury. Current Physical Medicine and Rehabilitation Reports.
Recovering from moderate to severe traumatic brain injury is complex. Researchers examined randomized control trials on complementary and alternative medicine therapies to understand what research has been done and the effectiveness of these therapies. Their findings? Some non-pharmacological approaches show promise in improving pain, mood and overall recovery, though more high-quality randomized control trials using larger samples of the population are needed to confirm effectiveness.
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Nelson M, Shi J, Lindsay MP, Salbach NM, Yao JK, …, McIntyre A, …, Mehrabi S, Mountain A; Canadian Stroke Best Practice Recommendations Advisory Committee, in collaboration with the Canadian Stroke Consortium, Canadian Neurological Sciences Federation, and CanStroke Recovery Trials Platform. (2025). Canadian stroke best practice recommendations: rehabilitation, recovery and community participation following stroke. Part one: Stroke rehabilitation planning for optimal care delivery, 7th edition update 2025. American Journal of Physical Medicine and Rehabilitation.
Salbach NM, Yao JK, Lindsay MP, Nelson MLA, Shi J, …, McIntyre A, …; Canadian Stroke Best Practice Recommendations Advisory Committee, in collaboration with the Canadian Stroke Consortium, Canadian Neurological Sciences Federation, and CanStroke Recovery Trials Platform. (2025). Canadian stroke best practice recommendations rehabilitation, recovery, and community participation following stroke, Part two: Delivery of stroke rehabilitation to optimize functional recovery, 7th edition update 2025. American Journal of Physical Medicine and Rehabilitation.
Yao JK, Salbach NM, Lindsay MP, Nelson MLA, Shi J, …, McIntyre A, …, Mehrabi S, …; Canadian Stroke Best Practice Recommendations Advisory Committee, in collaboration with the Canadian Stroke Consortium, Canadian Neurological Sciences Federation, and CanStroke Recovery Trials Platform. (2025). Canadian stroke best practice recommendations rehabilitation, recovery, and community participation following stroke, Part three: Optimizing activity and community participation following stroke , 7th edition update, 2025. American Journal of Physical Medicine and Rehabilitation.
Johari S, MacDermid J, Graham LJ, Ziebart CT, Shafiee E. (2025). A scoping review of principles of multisensory exercise training interventions in older adults emphasizing balance and fall incidence. Journal of Geriatric Physical Therapy.
Tsvetanov KA, Malpetti M, Jones PS, Rittman T, Whiteside DJ, …, Finger E, …; Genetic FTD Initiative, GENFI. (2025). Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia. Brain.
Zheng B, Nikpour M, Stevens W, Proudman S, Morrisroe K, …, Pope J, …, Thorne C (2025). Predicting trajectories of lung function decline in systemic sclerosis-related interstitial lung disease. Rheumatology.
Monchy N, Duprez J, Houvenaghel J-F, Legros A, Voytek B, Modolo J. (2025). Functional connectivity is dominated by aperiodic, rather than oscillatory, coupling. Journal of Neuroscience.
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Phillips NA, Fogarty J, Pilon R, Whitehead V, Best S, DiProspero C, Fouquet C, Beuk J, Mohades Z, Das S, Beaudoin C, Henri-Bellmare C, Anderson N, Belleville S, Brambati S, Einstein G, McLaughlin P, Chertkow H, Borrie M. (2025). The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) Study Neuropsychology Battery of the Canadian Consortium on Neurodegeneration in Aging (CCNA): Battery development and description. Canadian Journal on Aging.
How do we measure changes in memory and thinking as dementia progresses? Researchers from the Canadian Consortium on Neurodegeneration in Aging (CCNA) have developed a new tool, the COMPASS-ND Neuropsychology Battery. In this article, researchers describe how the comprehensive set of tests in the COMPASS-ND Neuropsychology Battery assess cognitive functions like memory, attention and language. This article provides helpful information on early and accurate brain health assessment for clinicians, researchers and families.
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Patience J, Burhan AM. (2025). “Emotional frailty” in older adults. The Routledge Handbook of Contemporary Ageing Issues.
MacDermid JC (2025). A primer on outcome measures. Evidence-Based Surgery.
Thomson M, Sharma V (2025). Bipolar disorder. Perinatal Psychopharmacology.
Safi A, Patience J, Blair M, Li KZH, Burhan AM (2025). Cognitive frailty in older adults. The Routledge Handbook of Contemporary Ageing Issues.
Sharma V, Palagini L, Mazmanian D (2025). Conclusion and recommendations for research. Sleep and Perinatal Psychiatric Disorders.
Stern N, Brock G (2025). Medicolegal mitigations for prosthesis complications. Complications of Urologic Prosthesis in Male Lower Genitourinary Reconstruction.
Thomson M, Sharma V (2025). Perinatal post-traumatic stress disorder and sleep pathology. Sleep and Perinatal Psychiatric Disorders.
Sharma V, Serdah H, Wood KN, Cha B (2025). Sleep disruption in bipolar disorder during and after pregnancy. Sleep and Perinatal Psychiatric Disorders.
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