Pieruccini-Faria F, Hachinski V, Son S, Montero-Odasso M. (2025). Apathy, gait slowness, and executive dysfunction (AGED) triad: opportunities to predict and delay dementia onset. GeroScience. 

Does the apathy, gait impairment and executive dysfunction (AGED) triad predicts earlier dementia onset? To find out, researchers followed 322 older adults for up to nine years. Researchers found 5% were diagnosed with AGED triad and had five times higher risk of developing dementia than individuals without AGED triad and those with fewer AGED triad components (i.e. 1 or 2). Hypertension and diabetes were also more common in the AGED group. The AGED triad may serve as a simple marker for accelerated dementia progression potentially linked with vascular risk factors.  

Mehrabi S, Cameron L, Bowman A, Fleet JL, Eng J, Bayley MT, Teasell R. (2025). A systematic review of female participation in randomized controlled trials of post-stroke upper extremity rehabilitation in low- to middle-income countries and high-income countries and regions. Cerebrovascular Diseases. 

How many women participate in randomized controlled trials (RCTs) for post-stroke upper limb rehabilitation in low- to middle-income and high-income countries was examined in this systematic review. The researchers analyzed 1,276 RCTs and found women were underrepresented everywhere with slightly higher participation in high-income countries. Female enrolment has not improved over the past two decades. These findings highlight the need for better inclusion of women in stroke rehabilitation research and are relevant to clinicians, researchers and policymakers. 

Mehrabi S, Flores-Sandoval C, Fleet JL, Cameron L, Teasell R. (2025). Comparing interventions used in randomized controlled trials of upper extremity motor rehabilitation post-stroke in high-income countries and low-to-middle-income countries. Archives of Physical Medicine and Rehabilitation. 

This study compared the types of therapies used in randomized controlled trials for upper limb rehabilitation after stroke between high-income and low-to-middle income countries. The researchers analyzed existing trials to identify differences in rehabilitation approaches. They found notable variations in the interventions used across these settings, likely reflecting differences in resources and health care infrastructure. The findings highlight the need for context-specific rehabilitation strategies. This article is relevant for clinicians, policymakers and researchers interested in global stroke rehabilitation practices.  

Seabrook JA, Avan A, O’Connor C, Prapavessis H, Nagamatsu L, Twynstra J, Stranges S, MacDougall A, Hachinski V. (2025). Dietary patterns and brain health in middle-aged and older adults: A narrative review. Nutrients, 17(9), 1436.  

How do different dietary patterns affect brain health in middle-aged and older adults? The authors of this narrative review examined existing research to determine if certain diets can help maintain cognitive function and reduce the risk of dementia. They found that diets rich in essential nutrients – such as the Mediterranean, Nordic and DASH diets – support brain health by reducing inflammation and promoting neurogenesis. These findings are relevant for health care providers, policymakers and adults interested in health aging. 

Hill JLE, Leonard E, Parslow D, Hill DJ. (2025). Gene Dystregulation and Islet Changes in PDAC-Associated Type 3c Diabetes. International Journal of Molecular Sciences. 

This paper shows that diabetes associated with pancreatic cancer does not represent a distinct immunological pattern but that the two diseases may mutually interact and drive the progression of both. The findings help explain why diabetes develops in some pancreatic cancer patients and suggests new directions for early detection and treatment. This research is relevant for clinicians, diabetes specialists and cancer researchers. 

Bateman EA, Viana R, Sales D, Payne MWC. (2025). Pregnancy after amputation: A national survey of prosthetic and mobility outcomes in women with lived experience.  Prosthetics and Orthotics International. 

What challenges do women with lower-limb amputations face during pregnancy? Researchers surveyed 16 Canadian women who had been pregnant after amputation and found that many experienced increased pain, changes in limb size, reduced prosthesis comfort and needed mobility aids like wheelchairs. These findings reveal unique difficulties and highlight the need for tailored support. This study is important for women with amputations, health care providers and rehabilitation teams seeking to improve pregnancy care and outcomes. 

Mehrabi S, Fleet J, Dukelow S, Murie-Fernandez M, Harnett A, Teasell R. (2025). Systematic review of upper extremity outcome measures assessed in randomized controlled trials of post-stroke upper extremity rehabilitation in low-to-middle-income and high-income countries. Archives Physical Medicine and Rehabilitation. 

This systematic review examined which outcome measures are used in randomized controlled trials of post-stroke upper extremity rehabilitation in low-to-middle-income and high-income countries. Analyzing 1,276 studies, the authors found significant differences in the choice of outcome measures between countries, likely influenced by available resources and expertise. The study highlights the need for standardizing outcome measures globally. Researchers, clinicians and policymakers involved in stroke rehabilitation should read this to inform best practices and future research directions.

Spangenberg GW, Uddin F, Habis AA, Faber KJ, Langohr GDG. (2025). Automatic determination of the resection plane for shoulder arthroplasty in arthritic humeri: A deep learning model. Journal of Shoulder and Elbow Surgery. 

This study developed a deep learning model to automatically identify the optimal bone-cutting plane for shoulder replacement surgery in arthritic patients. Researchers trained and tested their model on should images and found it accurately predicted where surgeons should make cuts, even in challenging arthritic cases. This advancement could improve surgical planning and outcomes Surgeons, radiologists and health care professionals involved in shoulder arthroplasty would benefit from learning about these findings. 

Teasell R, Mehrabi S, Saikaley M, George C, Dukelow SP, Harnett A, Fleet JL. (2025). A systematic review of upper extremity outcome measures assessed in randomized controlled trials of post stroke upper extremity rehabilitation over time. Topics in Stroke Rehabilitation. 

This research systematically reviewed which tests and assessments are used in clinical trials to measure arm and hand recovery after stroke. The team analyzed hundreds of studies to see how outcome measures have changed over time and found a wide variety in tools used, with some improvement in research quality but ongoing issues like small sample sizes and inconsistent methods. This study is important for clinicians, researchers and policymakers aiming to improve stroke rehabilitation research and care. 

Mehrabi S, Fleet JL, Safaei-Qomi MR, Dukelow SP, Murie-Fernandez M, Harnett A, Teasell R. (2025). Systematic review of upper extremity outcome measures assessed in randomized controlled trials of poststroke upper extremity rehabilitation in low-to-middle-income and high-income countries. Archives of Physical Medicine and Rehabilitation. 

This systematic review analyzed 1,276 randomized controlled trials on post-stroke upper extremity rehabilitation from low-to-middle-income and high-income countries. The study examined which outcome measures were used to assess arm and hand recovery over time. Researchers found 112 different measures, with most focusing on body functions and activities. The findings highlight the need for greater standardization in measuring stroke recovery. This review is relevant for clinicians, researchers and policymakers involved in stroke rehabilitation. 

Safaei-Qomi MR, Mehrabi S, Fleet JL, Peters S, Viana R, Payne MW, Tang A, Teasell R. (2025). Systematic review of worldwide female enrollment in randomized controlled trials of poststroke lower extremity rehabilitation. American Journal of Physical Medicine & Rehabilitation. 

This research systematically reviewed global studies to see how many women participate in randomized controlled trials for lower limb rehabilitation after stroke. The authors wanted to find out if women are under-represented in this important research area. They analyzed published trials, found that female enrollment is often low and highlighted the need for more balanced participation. These findings are important for researchers, clinicians and policymakers seeking fairer, more effective stroke rehabilitation for everyone. 

Choi JW, Lee JH, MacDougall A, Sharma V, Elfakhani M, Liu A, Kim BJ, Lee SJ, Lee YJ, Lim EJ, Kang N, Cha B, Lee D. (2025). Residual subjective depressive symptoms and resilience in patients with bipolar disorder. Journal of Affective Disorders. 

Understanding whether people with bipolar disorder who still feel some depressive symptoms experience lower resilience – the ability to cope with stress – was explored in this study. Researchers assessed patients’ lingering depressive feelings and measured their resilience levels. They found that ongoing depressive symptoms are linked to reduced resilience in these individuals. The findings suggest that boosting resilience could help improve outcomes for bipolar patients with residual depression. Mental health professionals and researchers interested in mood disorders should read this study. 

Plouffe RA, Houle SA, Birch M, Ein N, Nazarov A, Richardson JD. (2025). Validation of the Moral Injury Outcome Scale in Canadian health care workers. Psychological Assessment. 

This study tested whether the Moral Injury Outcome Scale (MIOS), a tool for measuring distress from morally troubling events, is reliable and valid for Canadian health care workers. Researchers analyzed responses from 786 participants and found that the MIOS accurately captures two main aspects of moral injury – shame and trust violation – similar to previous findings in veterans. The results support using MIOS in health care settings, making it valuable for clinicians and researchers studying staff well-being.

Shoemaker LN, Kamar F, Milej D, Fitzgibbon-Collins L, Eskandari R, Bhangu J, Shoemaker JK, St. Lawrence K. (2025). Two paths to one destination: Altered low-frequency oscillations of cerebral perfusion and oxygenation but not oxygen metabolism in mild cognitive impairment. Journal of Applied Physiology (1985-). 

Do people with mild cognitive impairment (MCI) show changes in brain blood flow and oxygenation rhythms and do these changes affect how the brain uses oxygen? Using advanced imaging, the researchers of this study found that individuals with amnestic MCI had reduced low-frequency oscillations in cerebral perfusion and oxygenation, but their brain oxygen metabolism remained unchanged. These findings suggest early vascular changes in MCI, which could help identify those at risk for dementia. Clinicians and dementia researchers should read this study. 

Roth ML, Wanklyn SG, Bird BM, Collins E, Gargala D, Houle SA, Forbes D, Nazarov A, Richardson JD. (2025). Problematic anger in a treatment-seeking Canadian veteran population: Prevalence, assessment, and treatment implications. Journal of Traumatic Stress. 

How common is problematic anger is Canadian veterans seeking mental health treatment, how does it relate to other psychological issues and what does this mean for care? In this study, researchers assessed 882 veterans and found that about 63% reported problematic anger, which was strongly linked to PTSD, depression, anxiety and harmful drinking. The findings highlight the need for routine anger screening in veteran care. This article is relevant for clinicians, policymakers and those working with military populations.

Liu JJW, Nazarov A, Ein N, Easterbrook B, Le T, Baker C, Gervasio J, Auger E, Balderson K, Bilodeau M, Burhan AM, Enns MW, Hosseiny F, Lavoie V, Mota N, Roth ML, Wanklyn SG, Richardson JD. (2025). Treating posttraumatic stress disorder in military populations: A meta-analysis. The Journal of Clinical Psychiatry. 

What are the most effective treatments for post-traumatic stress disorder (PTSD) in military populations? In this meta-analysis, examining over 400 studies, researchers compared psychotherapy, medication and their combination. They found that while both psychotherapy and medication alone are effective, combing them leads to the greatest improvement in PTSD symptoms. These findings suggest clinical guidelines should be updated. Clinicans, policymakers and anyone involved in veteran mental health care will find this an important read. 

Nazarov A, Brandwood A, Forchuk CA, Fraser B., Merchant W, Pavlovic B, Badell S, Guest K, Bailey S, Granek J, Richardson JD. (2025). Improving Mental Health and Resilience Training: Feedback from Military Personnel.. Journal of Military Social Work and Behavioral Health Services. 

This study explored which features of mental health and resilience training are most valued by military personnel. Using surveys with 567 Canadian Armed Forces members, researchers found that expert instructors, leadership support, practical skill practice and relevant content were most important. Less emphasis was placed on behavioral nudges or trainer-trainee similarity. The findings suggest that tailoring programs to these preferences could improve engagement and effectiveness. Military trainers, program designers and policymakers should read this article for actionable insights.