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November Lawson LEADS publications
Select articles published by Lawson scientists Sep. 23 – Oct. 27, 2025:
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Free to access full text:
The following research articles are free for the public to access. You can view a copy of the research by clicking on the title.
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Mau M, Leucht P, Frihagen F, Duque G, Yoon R, Schemitsch E, Haller J. (2025). Emerging basic science concepts in geriatric fracture fixation and patient recovery. OTA International.
How does aging affect bone healing and recovery after fractures in older adults? Researchers explored biological changes like bone loss and muscle decline to discover how they complicate recovery from surgery. They found age-related changes increase the risk of fractures and complicate surgery recovery, leading to higher chances for fixation failure, poor healing and wound complications. Early mobility after surgery can help with recovery but must be balanced with risks. Current fixation practices for should be adapted for older adults' unique biological challenges. This research emphasizes the need for personalized approaches and rehabilitation plans in geriatric care to reduce complications and improve outcomes. Orthopedic surgeons, geriatricians and rehab teams aiming to improve outcomes in elderly fracture care will find this research article valuable.
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Soltaninejad M, Dadar M, Collins DL, Rajabli R, Venkatraghavan V, …, Finger E, …, GENFI Consortium. (2025). White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia. Alzheimer's and Dementia.
Rodriguez-Vieitez E, Rydell MT, Ullgren A, Montal V, Illán-Gala I, …, Finger E, …, GENFI Consortium. (2025). Cortical microstructure is associated with disease severity and clinical progression in genetic frontotemporal dementia: A GENFI study. Molecular Psychiatry.
Gilsenan RT, Schwartz RE, Gutmanis IA. (2025). Clinician-caregiver engagement in older adult care. Development of a validated caregiver experience survey to inform the optimization of the caregiver role. Journal of Patient Experience.
Fitzgibbon-Collins LK, Best S, Noguchi M, Guest C, Borrie M, Shoemaker JK, Bhangu J. (2025). Neurovascular de-coupling underlies dual-task cost across cognitive abilities. Alzheimer's and Dementia: Translational Research and Clinical Interventions.
Varghese A, Kang Y, Cowan A, Holden R, Wald R, Clemens KK. (2025). Monitoring, control, and clinical outcomes associated with chronic kidney disease-mineral bone disorder: A population-based cohort study in Ontario, Canada. Kidney Medicine.
de Boer L, Jiskoot LC, Seelaar H, van Swieten JC, Ibanez A, …, Finger E, …, GENFI Consortium. (2025). Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia. Alzheimer's and Dementia.
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Elliott J, Hiebert B, Domm D, Chalmers K. (2025). Understanding the current and future states of behavioural supports Ontario: Protocol for a mixed methods pilot study. JMIR Research Protocols.
This study asks, how can Ontario’s Behavioural Supports program better serve older adults with dementia and their caregivers? To find out, researchers surveyed and interviewed staff and families across four regions in Ontario to assess current services and identify improvements to guide future care models. Health administrators, care teams and those interested in improving dementia care for older adults and their caregivers will find this article an important read about how to strengthen dementia support systems.
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Reischl S, Furtado R, MacDermid J, Grewal R, Schabrun S, Trejos AL. (2025). Effectiveness of mirror therapy to treat musculoskeletal injuries of the hand and wrist: A systematic review. Journal of Hand Therapy.
Mozaffaripour A, Tcherner S, Durom E, Kooner HK, McIntosh MJ, Sherwood M, Paul N, Serajeddini H, Bhalla A, Yamashita C, Parraga G. (2025). Airway mucus and (129)Xe MRI ventilation after single inhaler triple therapy in asthma. European Respiratory Journal Open Research.
Jeon P, MacKinley M, Dempster K, Ford S, Théberge J, Palaniyappan L. (2025). Activity-dependent modulation of glutamate, glutamine and glutathione in first-episode schizophrenia: A 7T functional MRS study. Schizophrenia Research.
Sadek J, Bazaid K, Harrington M, Choy A, Hamer D, …, Varapravan S, ... (2025). Psychiatric training during clerkship, part 2: Specific recommendations for reform-assessment and evaluation. Canadian Journal of Psychiatry.
Coleman BL, Bondy S, Fischer K, Gutmanis I, Zhu V, Kanchan K, Straus SE, Kim J, Simon S, McGeer A. (2025). SARS-CoV-2 infection following home, community and work-related exposures: A prospective cohort of teachers and education workers in Ontario, Canada, 2021-2023. BMJ Open.
Joshy M, Liu L, Dassanayake P, Aiello M, Di Cecca A, Cavaliere C, Anazodo U, Finger E, St Lawrence K. (2025). Disrupted coupling between cerebral glucose metabolism and intrinsic functional connectivity: A hybrid PET/fMRI study on frontotemporal dementia. Human Brain Mapping.
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Fitzgibbon-Collins LK, Noguchi M, Coombs GB, Hughson RL, Guest C, Amelard R, McArthur D, Peters S, Best S, Borrie M, Khan H, Shoemaker JK, Bhangu J. (2025). Navigating the brain: How cerebral blood flow shifts with task complexity. PLOS ONE.
How does brain blood flow change with task difficulty? Researchers studied older adults doing simple and complex tasks and found that blood flow increased with complexity, but performance declined. Clinicians, rehab teams and researchers in aging should read this study to explore new ways to assess cognitive and motor function.
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Heckman GA, Jantzi M, Hirdes JP, Nova A, Elliott J, Sinha S. (2025). Building a rational clinical information system for older adults in acute care: The role of the interRAI Acute Care Suite. Healthcare Management Forum.
Pistritto SC, Burhan AM, Chiu M, Elgazzar S, Lally P, Sun W. (2025). Exploring salivary Brain-Derived Neurotrophic Factor (BDNF) as a potential biomarker of neuroplasticity in older adults through exergaming. Cureus.
Bhat V, Thu KL, Goncalves Santiago AF, Bonvissuto AC, Ghasemi F, Goodale D, Roes MV, Passos DT, Dick FA, Cescon DW, Allan AL, Parsyan A. (2025). Artemis (DCLRE1C) acts as a target to enhance radiotherapy response in triple-negative breast cancer. Cancers.
Policelli R, Ward A, Dammak S, Kassam Z, Ramsewak D, Kalia V, Nadrah A, Wang D, Madubuobi H, Abbott C, Dawson C, McCarthy D, Balki I, Ladak I, Knezevic S, Marshall H. (2025). Testing remote feedback using a virtual semi-automated educational tool for the detection of pancreatic tumour-vessel contact on staging CT. Current Problems in Diagnostic Radiology.
Diksha, Donnelly SC, Suchy M, Cockburn N, Prato FS, Kovacs MS, Goldhawk DE. (2025). Radiolabelling bacteria with (89)Zr-DBN for PET/MRI: Comparing [(89)Zr]Zr oxalate and [(89)Zr]Zr phosphate. Nuclear Medicine and Biology.
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Vazquez-Guajardo M, Mimenza-Alvarado AJ, Martínez-Bravo LE, Rubalcava-Ortega J, Montero-Odasso M, Aguilar-Navarro SG. (2025). Association between small vessel disease and slow gait speed in older adults with cognitive impairment. Dementia e Neuropsychologia.
Is slow walking linked to brain changes in older adults with memory issues? Researchers studied 124 participants and found that small vessel disease, where there were white matter damage and tiny strokes, was tied to slower walking. Geriatricians, neurologists and rehab teams will find this an important read in early detection to prevent falls and cognitive decline.
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Cowan SS, Kosar L, Poon S, Bains M, Costigan J, Ducharme A, Gewarges M, Groulx S, MacFarlane K, Nagpal S, Singer A, McKelvie R. (2025). Prescription drug coverage of guideline-directed medical therapy for people living with heart failure with reduced ejection fraction in Canada. CJC Open.
Salonia A, Brock G. (2025). Erectile dysfunction: A harbinger of cardiovascular disease risk. Trends in Andrology and Sexual Medicine.
Wojcik S, Galatas C, Dekis A, Iacoviello L, Di Castelnuovo A, Costanzo S, Wang M, Fritzler MJ, Hudson M, Huynh T, Baron M, Gyger G, Ligier S, Pope J, Larché M, Khalidi N, Masetto A, Sutton E, Rodríguez-Reyna TS, Thorne C, Fortin PR, Ikic A, Robinson D, Jo. (2025). Limited utility of screening electrocardiograms in systemic sclerosis: Data from the Canadian scleroderma research group. ACR Open Rheumatology.
Coleman BL, Gutmanis I, Maunder R, Mcgeer A. (2025). Psychological distress is associated with symptoms of post-traumatic stress disorder among healthcare providers during the COVID-19 pandemic: 2021–2023. Frontiers in Psychology.
Shahmirzadi MR, Fowler M, Bondy L, Climans S, Lau J, To E, Iordanous Y, Phung M, AlMutawa F, Fuller J, Silverman M. (2025). The diagnostic challenge of a false-positive cryptococcal antigen in chronic meningitis with suspected indolent cns b-cell lymphoproliferative neoplasm. Journal of Fungi.
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Pay to access full text:
The following research articles are not free for the public to access. You must purchase a copy of the article or a subscription to the journal to read about the research. Alternatively, you may be able to request a copy of the article through the library at St. Joseph's or Western University via institutional subscription or by contacting the highlighted scientist.
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Xie JS, Kaur H, Lusterio A, Li HC, Adli T, Taboun O, Basilious A, Angold-Stephens A, Masket S, Mather R. (2026). A scoping review of ergonomics in ophthalmology: Working smarter. American Journal of Ophthalmology.
How can eye doctors reduce work-related injuries caused by poor posture? Researchers looked at 94 studies on ergonomic strategies in ophthalmology. They found that better equipment, posture training and fitness can lower injury risk. This matters because eye injuries can end careers. Ophthalmologists and those interested in eye health should read this to improve workplace safety and longevity.
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Cohen DJF, Drosdowech D, Murkin JM, Chui J. (2025). Assessment of amplitude and temporal differences of cerebral oxygen saturation in response to hypotension across multiple cerebrovascular territories during shoulder surgery. Journal of Nerosurgical Anesthesiology.
Norman E, Lalone E, Kadar A, Suh N, Langohr GDG. (2024). Muscle forces and articular loading following in vitro total wrist arthroplasty. Journal of Wrist Surgery.
Kadar A, Salman IM, Nikpour S, Hedberg YS. (2025). Implant analysis of a distally positioned volar locking plate - a microscopic proof of Soong's Theory?. Journal of Wrist Surgery.
Maruyama D, Doan TNM, Tian X, Chaki T, Yeh JJ, Layden BT, Prakash A. (2025). Gut microbiota-derived lipopolysaccharides and short-chain fatty acids regulate immune responses via FFAR2/FFAR3 in lung ischemia-reperfusion injury. Annals of the New York Academy of Sciences.
Pope J. (2025). Novel therapies in SSc. Best Practice & Research: Clinical Rheumatology.
Peters S, Fitzgibbon-Collins LK, Luan S, Kohli S, Durand N, Teasell R, Viana R, MacDonald SL, Bhangu J, Fleet JL. (2025). Functional and brain activation changes in females with subcortical subacute stroke captured through functional near infrared spectroscopy: A case series. Physiotherapy Theory and Practice.
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Zajner C, Hanna A, Zaman M, Bursztyn LLCD. (2025). Extraocular muscle enlargement in thyroid eye disease: A systematic review and meta-analysis. Canadian Journal of Ophthalmology.
How do eye muscles change in people with thyroid eye disease (TED)? To find out, researchers reviewed 23 studies comparing muscle eye size in TED patients versus health controls. They found people with TED had consistent muscle enlargement, especially in the inferior rectus muscle. This matters for diagnosis and treatment planning. Eye care professionals and radiologists should read this to better understand TED’s impact on eye anatomy, clinical diagnosis and patient treatment. Researchers may want to investigate this finding further using imaging.
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Tran J, McCormick ZL, Lanting BA, Lisk K, Loh E. (2025). Patient-specific knee radiofrequency ablation using contrast spread analysis and 3D anatomy knowledge: Teaching Images. Pain Medicine.
Tran E, Hadi A, Nair G, Bursztyn LLCD, Fraser JA, Ing EB. (2025). Incidence of alemtuzumab-induced thyroid-associated orbitopathy: A systematic review and meta-analysis. Ophthalmic Plastic and Reconstructive Surgery.
Brooks K, Stolee P, Elliott J, McAiney C. (2025). Enhancing behavioural support in long-term care: Evaluation of a regional behavioural support program for older persons living with dementia. Healthcare Quarterly.
Parsyan A, Athwal H, Bhat V, Allan AL. (2025). Polo-like Kinase 4 (PLK4) as a therapeutic target in breast cancer. Carcinogenesis.
Gross O, Averbeck MA, Musco S, Phé V, Vrijens D, Welk B, Werneburg GT, Kessler TM. (2025). 'BJUI Clinical Dilemma': The overactive bladder. BJU International.
Abdi K, Adams E, Agarwal S, Aliyu MH, Altamimi T, Andescavage N, ..., Duergen EG, ..., Zarrinnegar (2024). Proceedings of the 15th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal: Fota Island, Cork, Ireland, February 28th - March 2nd 2024. Journal of Neonatal-Perinatal Medicine.
Xing S, Cool DW, Tessier D, Chen ECS, Peters TM, Fenster A. (2026). A novel framework for integrating 3D ultrasound into percutaneous liver tumour ablation. Lecture Notes in Computer Science.
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Tcherner S, Mozaffaripour A, Yamashita C, Parraga G. (2025). Visualizing improvements in airway dysfunction after inhaled therapy in patients with uncontrolled asthma: A narrative review. Advances in Therapy.
Can a new type of MRI scan show how well asthma treatments are working in people with uncontrolled asthma? Researchers reviewed how inhaled therapies improve airway dysfunction in uncontrolled asthma and tried using hyperpolarized zenon-129 MRI to visualize treatment effects beyond standard lung tests. This research is vital for clinicians and respiratory researchers seeking better tools to assess and personalize asthma treatment.
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