A recent study reported that gastrointestinal problems co-occurring with autism might stem from gene mutations that are also linked to the behavioral symptoms of the condition.

Kara Gross Margolis and colleagues studied mice carrying a mutation also seen in some individuals with autism. The mutation reduces the activity of the neurotransmitter serotonin by increasing the activity of the serotonin reuptake transporter (SERT), which ferries serotonin back into neurons after it is released.

Over the past decade or so, researchers have begun to look deeply into the gut-brain connection. It may seem obvious that what happens in the brain can affect the gut, as the brain sends signals to all parts of the body. However, what happens in the gut may also affect the brain. Researchers are investigating the implications of this gut-brain connection for individuals with autism. 

Learn about the recognition and diagnostic evaluation of gastrointestinal issues autistic individuals, including their frequent presentation with behavioral manifestations.

Recent ARI grant recipients researching gastrointestinal issues:

• Harland Winter, M.D., Massachusetts General Hospital. Is there a relationship between the gut mucosal-associated microbiome, intestinal neurotransmitters and behavior in individuals on the autism spectrum?
• Natalia Battista, Ph.D., University of Teramo Faculty of Bioscience and Technology for Food, Agriculture and Environment. Cross-talk between food-borne Lactiplantibacillus (Lpb.) plantarum and the endocannabinoid system towards Autism Spectrum Disorder
• Rosa Krajmalnik-Brown, Ph.D., Arizona State University. Effect of Microbiota Transfer Therapy on Gut Mycobiota in Adults with ASD

2023 ARI Scientific Think Tank

Since 1995, ARI has called together experts to discuss emerging autism research at its annual think tanks -- we marked our 28th year of these meetings last weekend in Chicago, IL. All year, and especially during Autism Science Month, we are honored to put words into action supporting the health and well-being of people affected by autism through innovative, impactful research and education.