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The asset redirected T-Cell activation to kill B7-H3+ AsPC-1 (pancreatic cancer) and NCI-N87 (gastric cancer).
- The asset suppresses tumor growth in NCI-N87 xenograft model.
▶ Good safety in preclinical study.
- The Asset shows a positive safety profile in toxicity studies with Cynomolgus Monkeys.
✓There were no animal death and no adverse effects
✓No liver impairment was observed, compared to other BsAb target CD3 and B7-H3.
✓The asset induced very low cytokine release(IL-2, IL-6, TNF-α, IFN-γ) in Cynomolgus monkeys.
- The asset is well-tolerated in Cyno monkeys and the NOAEL is the highest dose tested at 3.6 mg/kg once weekly for 4 consecutive weeks (5 doses in total).
▶ Innovative BsAb development platform
- After reasonable design of heavy and light chains, the mismatch probability of asset is greatly reduced.
- Creative CMC, which greatly simplified the production and purification process, through one step affinity chromatography the purity can be higher than 95%.
- The platform brings a much lower cost of production.
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