DART ® MS @  IMSC Toronto                                         August 2016    
Direct Analysis in Real Time Mass Spectrometry on Display

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The International Mass Spectrometry Conference is upon us and for the first time its in North America!   Being so close to Boston we have decided to bring both our  DART configured Waters Acquity QDa compact-MS and  "Pimisa" , our novel software program for near real time chemical screening  to the show.  We will also show our new Thermal Desorption chamber ideal for use with SWAB based samplers , and Pyrolysis probe technologies.

Please stop by the IonSense   booth # 
1218 at the  IMSC

Also visit our Wednesday posters presented by Rob describing the
Thermal Desorption probes W-T-137 and  Fred describing PIMISA W-T-199  
For those of you who missed ASMS in San Antonio this year there is still time to view the posters from DART users by visiting the ASMS web site.  Below we present a few abstracts from notable posters.  

Feel free to contact me if you have any questions or comments about these posters or our products. 

Best regards,

Brian Musselman, Ph.D.
President and CEO

Notable DART Application Posters from ASMS 

The Complete DART Bibliography is Now Available - CLICK HERE

Direct Quantification Technique for Natural Moisturizing Factor (NMF) in Stratum Corneum by DART-MS
Katsuyuki Maeno , and Haruo Shimada. Shiseido Global Innovation Center, Yokohama
Yasuo Shida, University of Yamanashi, Kofu, Japan  

DART-MS is used for direct quantification of natural moisturizing factor (NMF) components in stratum corneum (SC), such as urea, pyrrolidone carboxylic acid, lactic acid and amino acids. NMF components play an important role in maintaining proper moisture levels in the SC. However, DART-MS has been considered not to be suitable for a quantitative analysis due to the matrix effects that are practically unavoidable in ambient ionization techniques . In this study, we have targeted amino acids as NMF and employed appropriate stable-isotope-labeled internal standards (SIL-IS) to overcome the quantitative problem of DART-MS. We have tried to develop a rapid, simple and quantitative analytical technique for NMF components.

Dopant-Assisted Direct Analysis in Real Time Ionization with Argon Gas
Robert B. Cody* and A. John Dane. 
JEOL USA, Inc. 11 Dearborn Rd, Peabody MA 01960 USA

The Direct Analysis in Real Time (DART) ambient ionization source is commonly operated with helium or nitrogen gas causing direct ionization of the analyte, or indirect ionization through ion-molecule reactions involving atmospheric gases such as water and oxygen. With two exceptions in the literature, argon has not been used as a DART gas because the internal energies of metastable argon states are lower than the ionization energy of water and oxygen. Here we show that dopant-assisted argon DART follows mechanisms analogous to those proposed for dopant-assisted atmospheric pressure photoionization (APPI) and that common APPI dopants can also be used with argon DART. The ionization mechanism can be controlled by selecting dopants that favor charge exchange or proton transfer.

Inert-atmospheric solid analysis probe (ASAP): a new fast and easy way to characterize  air sensitive compounds by mass spectrometry 

Mathilde Farenc, Carlos Afonso, Pierre Giusti
TOTAL Refining Company  - CNRS Joint Laboratory C2MC: 
Complex Matrices Molecular Characterization, France

Metallocenes are used on an industrial scale for olefin polymerization  and are highly reactive toward moisture and  oxygen. The analysis of air sensitive molecules by mass  spectrometry (MS) is always a difficult task.   The principal challenge is to transfer the molecules from  the inert atmosphere to the source of the instrument. One  solution developed by Trefz at al., is to couple the mass  spectrometer to a glove box. The sample can be then infused  to the source using a syringe pump but glove boxes  are very rarely located close to mass spectrometers. Moreover  this method require to solubilize the sample with an  ESI compatible solvent.   We developed a new approach based on the atmospheric  pressure analysis probe (ASAP) that allows the transfer of  air sensitive samples and the transfer of air sensitive samples and their release directly into the source chamber.
About IonSense
IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. We manufacture and develop direct analysis in real time (DART ®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and  ASAP Sources are available for most commercial LC/MS systems.   Look here to see if your system is DART-ready.  And    check here to see if your system is ASAP-ready.

For your local representative, please see our distributor network. 

Phone - 781.484.1043  | |