-Table: Half standard (mono-therapy) dosing achieved 80% of the blood pressure lowering effect of full dose therapy (
BP reductions depicted as treated minus placebo, reductions in diastolics comparable). Among a heterogeneous population, the degree of BP reduction was similar between classes of agents.
-Mean BP reduction with full dose combination therapy (irrespective of agents) was 14.6/8.6 mm Hg; half standar
d dose combination therapy was 13.3/7.3 mm Hg.
-Figure: Among thiazides, CCBs, and
, side effects were dose dependent. ACEi/ARB related adverse effects (principally cough) were dose independent.
-Among all patients on mono-therapy (regardless of dose), 5.0% reported side effects. Among all patients on combination therapy (regardless of dose), 7.5% reported side effects.