NEW: Patient Blog

Jen Feinberg – Lessons From The Trenches

NEW Webinar Recording Available

Leptomeningeal Spread and Breast Cancer

NEW Research Articles

Stay up-to-date with the latest findings. Explore these recent studies and see what they might mean for you and your care.

November 26, 2025

Patritumab deruxtecan (HER3-DXd) in patients with active brain metastases of breast cancer (TUXEDO-3): a multicentre, single-arm, phase 2 trial

Rupert Bartsch, Maximilian Marhold, Javier Garde-Noguera, María Gion, Manuel Ruiz-Borrego, Richard Greil, María Valero, Antonio Llombart-Cussac, Juan José García-Mosquera, Miriam Arumi, Javier Cortés, Marta Campolier, José Antonio Guerrero, Felipe Slebe, Elena Martínez-García, Carlos Jiménez-Cortegana, Marta Vaz-Batista, Felicitas Oberndorfer, Julia Furtner, Thorsten Fuereder, Anna Sophie Berghoff, Matthias Preusser

The TUXEDO-3 study tested a new treatment, HER3-DXd, in people with active brain metastases from breast cancer. In this small phase 2 trial, about 5 (24%) of 21 patients had an overall response, even though most participants had already received many prior treatments. Importantly, responses were seen across all breast cancer subtypes, including HER2- positive, HER2-low, and HER2- negative disease.

Patients' quality of life and neurological function stayed stable during treatment, which is especially important for people living with brain metastasis. Common side effects included neutropenia, fatigue, nausea, hair loss and diarrhea.

Although this was an early small study and more research is needed, the results are encouraging. HER3-DXd may become a future treatment option for people with brain metastases from breast cancer.

Organizations that Provide Patient Support

Leptomeningeal Cancer Foundation



The Leptomeningeal Cancer Foundation (lmcancer.org) is a patient founded organization dedicated to offering hope, support, and education for those facing leptomeningeal cancer (LMC), a rare condition where cancer spreads to the brain and spinal cord membranes. The foundation also works to raise awareness and advance research for better diagnostics and treatments.

Private Facebook Group

Leptomeningial Disease (LMD) Community and Support

Founded by twin sisters Kyle and Briana Greenemeyer after Briana’s diagnosis, this group offers patients, families, and caregivers a safe space to share experiences, access information, and have honest conversations about treatment, side effects, and living with leptomeningeal disease.

This is a Zoom Support Group meeting twice a month from 3:00-4:30 ET. The group is for women of all ages who have been diagnosed with brain metastases or leptomeningeal disease from breast cancer. Please join us to find hope, support and information from others living with this disease. 

Registration is required for new participants.

Would you like to Share your Story?

We want to hear from YOU!



We have two different opportunities for you to share your story: blog and video. Your patient voice and story matters. Sharing your story can provide hope and inspiration to others diagnosed or undergoing treatment.

Patient Blog

Would you like to write about your story? For questions or to submit your blog, please email mbcbrainmets@gmail.com for guidance.

No patient should have to go through MBC brain metastasis alone. Read some of our patient stories which are vulnerable, honest, and poignant.

Patient Video

If you are interested in creating a video, please email mbcbrainmets@gmail.com for guidance.

Take a look at the videos from patients living with brain metastasis who share their experiences of receiving a brain metastasis diagnosis, participating in a clinical trial, and undergoing treatments like a craniotomy, whole brain radiation, and others.