June 2, 2023

Announcements, events, funding opportunities and more news for the Mass General Research Institute community.

In this edition:

(Scroll down for more info and click on the links for additional details)


Funding Opportunities


  • Smith Family Awards for Excellence in Biomedical Research
  • Harrington Scholar-Innovator Award
  • NIH Director’s Early Independence Awards


Announcements:


  • NEW! Overhead Costs for Industry-Sponsored Clinical Trials to Increase July 1
  • NEW! Call for Summer Research Training Program Abstract Reviewers & Final Presentation Panelists
  • NEW! IACUC Policy Update
  • NEW! All of Us Research Program Celebrates 5 Years and Milestone Achievements with Release of Nearly 250,000 Whole Genome Sequences
  • MathWorks Training
  • SAS license renewals 
  • BioRender licenses
  • Software Offering: ChemDraw


Events:


  • NEW! Research Council Monday, June 5
  • NEW! 2023 Virtual Tumor Course: Registration Now Open
  • MGB World Medical Innovation Forum
  • The 24th Annual Harvard Nutrition Obesity Symposium
  • Meditation Sessions available every week

THE SMITH FAMILY AWARDS

FOR EXCELLENCE IN BIOMEDICAL RESEARCH


What are they?

The mission of the Awards Program is to launch the careers of newly independent biomedical researchers with the ultimate goal of achieving medical breakthroughs. The three‐year Award supports newly independent faculty engaged in basic or translational biomedical research. Investigators in the physical sciences (physics, chemistry and engineering) whose projects focus on biomedical science are also encouraged to apply. While basic research projects involving human subjects, data, and samples are eligible, clinical trials research is beyond the scope of this program.


“In recognition of the importance of research collaboration by the scientific community, collaboration is an additional, but not required, positive ancillary factor. These projects may involve researchers within and/or outside MGH.”


This opportunity is open to full-time faculty at MGH who received or will receive their Assistant Professor appointment on or between 10/1/20 and 4/1/24. The award is $400,000 over three years, inclusive of 5% institutional overhead. 


The foundation now has a two-stage application process, and there are no limits on the number of applications from an institution. An internal selection process is no longer required. All eligible faculty at MGH should apply directly to the sponsor.


Please contact Foundation Relations in the Office of Development at devcfr@mgh.harvard.edu if you wish to submit a proposal in response to this opportunity. They will be able to advise you on the application process.


Initial proposal deadline: Tuesday, June 20, 2023 at 12:00 Noon (Those applicants who make it to the second stage will be invited to submit a full proposal in early October).

Learn more

HARRINGTON SCHOLAR-INNOVATOR AWARD


What are they?


Harrington Discovery Institute (HDI) invites you to submit an LOI for the 2024 Harrington Scholar-Innovator Award. The award offers successful applicants multiple opportunities for funding in addition to expertise from pharma-experienced leaders with a track record of bringing drugs to market. Intellectual property rights are retained by the award recipient or their institution.

 

Up to 12 Scholar-Innovators will be selected to receive:

 

  • $100,000 guaranteed grant award;
  • Drug and business development support from Harrington’s Therapeutics Development Center advisors; 
  • Opportunity to compete for acceleration funds up to $300,000;
  • Opportunity to qualify for investment funds typically up to $2MM;

 

Selection criteria include innovation, creativity and potential for impact on human health. Applicants must have a doctorate in medicine. Award recipients will be selected by Harrington Discovery Institute’s Scientific Advisory Board and announced in the second quarter of 2024.

 

**MD or MD/PhD required for eligibility. Open to physician-scientists in the U.S. and Canada.


Call Opens: April 10, 2023

Letters of Intent (LOI) Due: June 5, 2023

Learn more

NIH Director’s Early Independence Awards


What are they?

The NIH Director’s Early Independence Award Program supports exceptional investigators who wish to pursue independent research directly after completion of their terminal doctoral/research degree or clinical residency, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career.


The Early Independence Award is intended for these select junior investigators who have already established a record of scientific innovation and research productivity and have demonstrated unusual scientific vision and maturity; typical post-doctoral training would unnecessarily delay their entry into independent research.


MGH is eligible to nominate two candidates for the NIH Director’s Early Independence Award.

 

When is the deadline?  

MGH internal pre-proposal: Tuesday, June 20, 2023 – 5:00 PM

Learn more

Limited Submission Funding Opportunities


We ask that all MGH Investigators interested in applying for any limited submission award submit a Letter of Intent (see detailed instructions below) to the MGH Executive Committee on Research (ECOR) by the deadline indicated for each award to be considered to receive an institutional nomination. 


CURRENT OPPORTUNITIES:

See full details for all awards on our website.


Population Dynamics Centers Research Infrastructure Program FY 2024 (P2C Clinical Trial Not Allowed)


The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research. 


To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on:


  • Courses for Skills Development
  • Research Experiences


This Funding Opportunity Announcement (FOA) provides support to eligible, domestic institutions to develop and implement Postbaccalaureate Research Education Programs in Diabetes, Endocrinology and Metabolic Diseases (DEM).


These post-baccalaureate research programs will incorporate extensive research experiences and well-designed courses for skills development to prepare recent college graduates from diverse backgrounds, including those from underrepresented groups, to transition into and complete rigorous, research-focused biomedical doctoral degree programs (e.g., PhD or MD/PhD).


The long-term goal of post-baccalaureate participants admitted to the program should be pursuing a career focused on DEM-related research.


Eligible applicants for the R25 must be research-intensive doctoral degree-granting institutions with a research base in DEM science of at least $3 million in direct costs of peer-reviewed research projects, and research opportunities for students admitted to the program must be in DEM science.


MGH LOI Deadline: 6/07/23

NIH LOI Deadline: 6/28/23

NIH Application Deadline: 7/28/23

Learn more


G. Harold & Leila Y. Mathers Foundation Grants


The G. Harold & Leila Y. Mathers Foundation seeks to advance knowledge in the life sciences by supporting scientific research that will benefit humanity. The Foundation primarily supports basic science, ideally with broad translational applications. It tends not to fund overly disease-focused research. Immunology, microbiome, genomics, structural biology, cellular physiology, and neuroscience are some noteworthy examples of current research support. 

Foundation Guidelines:

·      Grants are typically up to $750,000, inclusive of 10% indirect costs.

·      Grant duration must be 3 years.

·      The budget should be reasonable (based on the aims of the project, the number of researchers involved, type of animal models used, etc.).

·      Grant funds may be used only to support the actual investigation (no capital equipment).

·      Requests for funding previously federally supported research, and/or applications pending federal approval will not be accorded priority consideration.

·      The Foundation does not support clinical trials or drug discovery.

·      The Foundation will not support projects which it considers pre-clinical drug development.

·      Covid-19 related research projects (aims or sub-aims) and medical imaging technology related projects will not be considered for support.

·      LOIs or Formal Proposals that have been declined should not be resubmitted at a later date for consideration. 


MGH LOI Deadline: 6/21/23

Sponsor LOI Deadline: 7/28/23

Sponsor Application Deadline: 9/29/23

Learn more


Postbaccalaureate Research Education Program in Diabetes, Endocrinology, and Metabolic Diseases (R25 – Independent Clinical Trial Not Allowed)


The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research. 


To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on:


  • Courses for Skills Development
  • Research Experiences


This Funding Opportunity Announcement (FOA) provides support to eligible, domestic institutions to develop and implement Postbaccalaureate Research Education Programs in Diabetes, Endocrinology and Metabolic Diseases (DEM).


These post-baccalaureate research programs will incorporate extensive research experiences and well-designed courses for skills development to prepare recent college graduates from diverse backgrounds, including those from underrepresented groups, to transition into and complete rigorous, research-focused biomedical doctoral degree programs (e.g., Ph.D. or M.D./Ph.D.).


The long-term goal of post-baccalaureate participants admitted to the program should be pursuing a career focused on DEM-related research. Eligible applicants for the R25 must be research-intensive doctoral degree-granting institutions with a research base in DEM science of at least $3 million in direct costs of peer-reviewed research projects, and research opportunities for students admitted to the program must be in DEM science.


MGH LOI Deadline: 9/05/23

NIH LOI Deadline: 9/25/23

NIH Application Deadline: 10/25/23

Learn more


1.      EPSCoR Collaborations for Optimizing Research Ecosystems Research Infrastructure Improvement Program (National Science Foundation)


The Established Program to Stimulate Competitive Research (EPSCoR) fulfills the mandate of the National Science Foundation (NSF) to promote scientific progress nationwide. Through this program, NSF facilitates the establishment of partnerships among academic institutions, government, industry, and non-profit sectors that are designed to promote sustainable improvements in the research infrastructure, Research and Development (R&D) capacity, and R&D competitiveness of EPSCoR-eligible jurisdictions (i.e., states, territories, and commonwealths).

The E-CORE RII program supports jurisdictions in building capacity in one or more targeted research infrastructure cores that underlie the jurisdiction's research ecosystem. Based on the evidence-based and self-identified need of the jurisdiction, capacity building supported by E-CORE RII may include (but is not limited to) development, enhancement, and/or sustainability of: jurisdiction-wide research administration; research facilities; higher education pathways; STEM education (K-16) pathways; broadening participation; workforce development; national and global partnerships; community engagement and outreach; economic development and use-inspired research; and/or early career research trainee pathways.


E-CORE RII projects must be designed to support the sustainability of the infrastructure core(s) beyond the award period. In E-CORE RII's support of one or more research infrastructure cores in an EPSCoR-eligible jurisdiction, the program will also support the development and growth of new jurisdictional networks, and the leveraging of existing jurisdictional networks, that can drive demonstrable and sustainable impact to advance the jurisdiction-wide research ecosystem.

Through the fostering of STEM research ecosystems and research capacity pathways across institution types and sectors in a jurisdiction, E-CORE RII aims to support jurisdiction-wide research infrastructure cores based on jurisdictional variability.


A jurisdiction's science, technology, engineering, and mathematics (STEM) research ecosystem encompasses all new and ongoing interactions among its research environment, researchers, stakeholders, and STEM research activities to improve knowledge, or contribute to end-use or societal impacts in the jurisdiction.


MGH LOI Deadline: 10/09/23

Sponsor Application Deadline: 12/06/23

Learn more

Foundation Funding Opportunities


Please contact Corporate & Foundation Relations in the Office of Development at devcfr@mgh.harvard.edu if you wish to submit a proposal in response to any of these opportunities. Note that proposals are still routed through the standard InfoEd/Research Management process.



CURRENT OPPORTUNITIES:

See full details for all awards on our website.

  1. ABPN Dorthea Juul, PhD, Education Research Award, American Board of Psychiatry and Neurology, Inc. $100,000. Application Deadline: August 8
  2. Grand Challenge Awards, Cancer Research UK (CRUK). $25 million. Questionnaire Deadline: June 15
  3. CONquer canCER Now Award, Concern Foundation. $150,000. LOI Deadline: July 3
  4. Making a Difference in Real-World Bioethics Dilemmas, Greenwall Foundation. Unspecified amount. LOI Deadline: June 26
  5. Edward N. and Della L. Thome Memorial Foundation Awards Program in Alzheimer’s Disease Drug Discovery Research, Health Resources in Action (HRiA)/The Medical Foundation. $500,000. Preliminary Proposal Deadline: July 13
  6. NEW! Waite-Griffin SBMA Fellowship, Kennedy's Disease Association (KDA). $77,000. Proposal Deadline: July 3
  7. Seed Grants for Research in Childhood Cancer (multiple opps), Pablove Foundation. $100,000. LOI Deadline: July 5
  8. Research Grants, The Cure JM Foundation (Cure JM). $150,000. Application Deadline: June 30
  9. Edmond J. Safra Fellowship in Movement Disorders, The Michael J. Fox Foundation for Parkinson's Research (MJFF). $180,000. Application Deadline: December 7


Do you want to learn more about identifying external funding opportunities? Please click here to request a research consultation with Amy Robb or see ECOR’s website for information on the Pivot database.

LEARN MORE

Overhead Rate for Industry Sponsored Clinical Trials will Increase from 30% to 35%

Effective July 1, 2023


The current overhead rate for industry-sponsored clinical trials of 30% has not been increased in over 8 years. Mass General Brigham’s Clinical Trials Office (CTO) reviewed the rates charged by other academic medical centers and research institutions for industry-sponsored clinical trials in the United States, and institutional expenses required to support clinical trials at Mass General Brigham’s institutions. 


From this review, we made the decision to increase the rate to 35% of total direct costs. 


This increase brings Mass General Brigham’s rate in line with rates charged by other academic medical centers and research institutions and is necessitated as a result of increased volume and complexity of contractual arrangements, financial assessments, and institutional reviews (e.g., IRB, information security, etc.) in connection with industry-sponsored clinical trials, which require adequate staffing to improve service, and rising costs of services and personnel due to inflation. 

On or after July 1, 2023, all new agreements for clinical trials sponsored or funded by industry that are accepted by CTO will be subject to the 35% rate. Read more.

Call for Summer Research Training Program

Abstract Reviewers & Final Presentation Panelists


Abstract Reviewers:

Review 3 – 4 abstracts and discuss feedback with students via Zoom

Zoom meeting options (1 hour/15 min per student):

July 12: Anytime between 8 am to 1 pm or 4:30 pm to 6:30 pm

July 13: Anytime between 8 am to 1 pm or 4:30 pm to 6:30 pm

Provide your availability


Final Presentation Panelists:

Listen and score student presentations, and provide written feedback

Student final presentations schedule:

July 11 (1 student) – 5 pm to 6 pm

July 26 (13 students) - 11:30 am to 5:30 pm

July 27 (13 students) - 7:30 am to 1:30 pm

August 3 (3 students) - 1 pm to 2 pm, 4 pm to 5 pm, or 5 pm to 6 pm

Provide your availability

IACUC Policy Updates

 

The following new and revised policies have been approved by the MGH IACUC and are available for review on the MGH IACUC website.

 

Effective July 1, 2023:

  • Policy on Monoclonal Antibody Production, Version 1.4

 

Please review these policies to ensure that you are following current requirements and be sure to update any relevant documents and practices you may have in your laboratory. 

 

If you have any questions, please contact the MGH IACUC Office or MGH IACUC Compliance.  

All of Us Research Program Celebrates 5 Years and Milestone Achievements with Release of Nearly 250,000 Whole Genome Sequences to Advance Precision Medicine

 

The National Institutes of Health's All of Us Research Program is celebrating its five-year anniversary this month with the recent expansion of the program’s dataset, which now includes nearly a quarter million whole genome sequences for broad research use.


About 45% of the data was donated by people who self-identify with a racial or ethnic group that has been historically underrepresented in medical research.


The data expansion provides registered researchers access to the world’s largest and most diverse dataset of its kind, paving the way to help advance health equity and uncover health care approaches better tailored to people's genes, lifestyles and environments.

 

Massachusetts General Hospital is an enrollment partner for All of Us in New England, and has played a critical role in this milestone, working to nurture relationships with diverse participants from throughout the region to ensure strong diversity in the dataset.


To date, more than 32,700 participants have joined All of Us in New England. The genomic data is available to approved researchers across the Mass General Brigham (MGB) system with information from surveys, physical measurements and biosamples (blood, urine and/or saliva), electronic health records (EHRs), and wearable devices. Learn more.


Mass General Women in Leadership Group

Seeking Membership Applications


The Mass General Women in Leadership Committee is now welcoming applications for new member-at-large positions for a two-year term beginning October 1, 2023.

 

Committee membership is open to all MGH female-identified administrative, clinical leaders and research staff. We ask members to regularly attend monthly meetings, participate in WIL events and serve on at least one subcommittee. Reaffirming MGH’s dedication to creating an inclusive community, we hope that people of diverse backgrounds and career paths will apply to maintain and foster a supportive professional network.

 

To apply, please complete the application form linked here by Friday, June 30. The first eight questions on page one request contact and demographic information. The four questions on page two are listed below for your reference. Applications can be submitted by selecting “done” on page three. Please note that all submissions will go through a de-identification process.


  1. Please describe your particular interest in becoming a member of the WIL Committee and what you hope to gain from the experience.
  2. Please describe ways in which you have demonstrated inclusive leadership in your role at MGH, regardless of your formal position.
  3. Please describe how you can contribute to the advancement of the MGH female-identified professional network and your proposed level of involvement.
  4. Is there anything else you would like the WIL selection committee to know? 

 

To learn more about WIL, please visit our website at https://apollo.massgeneral.org/wil-committee/. We will also host a Virtual Open House on Tuesday, June 13 from 10:30am-12:30pm via Zoom. You can register here. We have no formal agenda and invite you to drop in when you can to ask questions and learn more about WIL. If you have any questions, please email us at MGHWIL@mgb.org. 

Software Offering: Chem Draw


Time to renew your ChemDraw license through the ERIS Research Computing Core. Annual ChemDraw licenses expire each year on May 25th. Your license will automatically cancel, and you will need to order again at rcservices.partners.org (MGB login required).


ChemDraw licenses are $70/year per User and new licenses can be ordered and accessed today.


ChemDraw is a powerful, yet easy-to use, tool for producing chemical and biological drawings. You can create your own drawings or use those provided in the library of available templates. For more information on ChemDraw go to the Research Computing Core's software page. All questions may be directed to rcc@partners.org.

MathWorks Training


Online training is available, offered by MathWorks.

SAS license renewals 


SAS licenses expire each year on April 30th and will automatically renew. No action is required, unless you no longer need your license. To cancel your SAS license, log into your account at rcservices.partners.org to cancel.

BioRender licenses



BioRender Software: Annual License Renewal and Signup:

If you have a BioRender license through the Research Computing Core, it's time to renew. BioRender licenses expire each year on April 30th and can be renewed, starting May 1st. Request a software license through the ERIS Research Computing Core Service Catalog. The annual fee is $185/license. More information about BioRender, and other software offerings are on the ERIS Research Computing Core Service Catalog site.

Research Council

Monday, June 5, 2023

12:00 pm to 1:00 pm


Chair: Yakeel Quiroz, PhD

Lunch will be available in the Simches Auditorium 3.110

In-Person option: Simches Auditorium, room 3.110

Zoom option: https://partners.zoom.us/j/82612518339?pwd=dlpxeHVtd2FwMERUUlFYZGJTbjROQT09

Meeting ID: 826 1251 8339

Passcode: 366529

 

Agenda:

IRB Update

Martha Jones, Vice President, Human Research Affairs


Minors in Laboratories

Kele Piper, Director, MGH Research Compliance

 

New Solutions from Research Compliance: Transfer Out Process 

Mirabella Daguerre, Senior Research Compliance Specialist 

June 2023 Anne Klibanski Visiting Lecture

Tuesday, June 6, 2023

1:00 pm to 2:00 pm


Dr. Marlene Hager, from the Medical University of Vienna in Vienna, Austria will be speaking about Functional Hypothalamic Amenorrhea and PCOS – Interrelations and Differentiations.

Register

2023 Virtual Tumor Course

Tuesday, Oct. 24 to Friday Oct. 27, 2023

38TH CRITICAL ISSUES IN TUMOR MICROENVIRONMENT, ANGIOGENESIS, METASTASIS AND IMMUNOLOGY

The 38th Annual Critical Issues in Tumor Microenvironment: Angiogenesis, Metastasis and Immunology course will continue to offer the best in critical analysis of what is currently known about the tumor microenvironment, angiogenesis, metastasis, immunology. This will include chimeric antigen receptor (CAR) T-cell therapies, tumor metabolism, and the role of microbiome.


The internationally recognized faculty speakers will present their latest findings from the clinic and the lab and highlight key gaps in the knowledge of cancer and outline future directions for research at the bench, in the clinic, and in drug development.


The course will continue its four-day online webinar-based live lecture format. Learning formats will include didactic lectures, Q&A and group case discussions.


The faculty will encourage an open discussion and will provide critical comments on challenges and future opportunities in research in cancer and in establishment of novel therapy approaches and biomarkers to guide treatment. The aim of this course is to analyze and synthesize the most up-to-date findings.


Faculty will present valuable information in a systematic and comprehensive framework, along with a critical review of the latest techniques. This course is dedicated to helping to improve clinical translation of this knowledge and competence, leading to improved cancer treatment.

Register
Course Schedule & Details

MGB World Medical Innovation Forum

June 12-14, 2023

Boston's Top Healthcare Innovation Gathering


Join leading healthcare and financial experts at the World Medical Innovation Forum as they assess the impact of the latest innovations in three of today’s fastest breakthrough areas.


Network with industry disruptors and executives, including top Harvard clinicians and scientists from Mass General Brigham, the premier academic research organization and medical system in the U.S., and financial experts from Bank of America, manager of one of the largest healthcare portfolios in the industry.

Learn More

The 24th Annual Harvard Nutrition Obesity Symposium – Adiposity, Immunity, and Inflammation: Interrelationships in Health and Disease

Date: June 7, 2023

Time: 8:30am to 4:30pm EST 


The Nutrition Obesity Research Center at Harvard (NORCH) invites you to attend our 24th Annual Symposium, featuring the latest research on a wide range of topics including nutritional regulation of immunity, immunometabolic drivers of heart failure, and immunological landscape of adipose tissue. The George L. Blackburn Keynote Lecture, "Obesity and Immunometabolism," will be given by Dr. Lydia Lynch of Harvard University School of Medicine.

 

Additional event info and speaker information can be found here.

This event will be held virtually. All are welcome!

Registration is free for all attendees. Register now

Register

Two Meditation Sessions available every week



SESSION 1: Meditation Mondays with Dr. Darshan Mehta 

Every Monday, 8:00 – 8:30 am, Zoom à next session, Monday, June 5!

Co-sponsored by the Center for Faculty Development’s Office for Well-Being and the MGPO Frigoletto Committee

Join Darshan Mehta, MD, MPH, Director, Office for Well-Being, for a guided meditation session on Monday morning. 

Register and add to calendar

 

SESSION 2: Midweek Meditation with Guest Leader 

Every Wednesday, 8:00 – 8:30 am, Zoom à next session, Wednesday, June 7!

Sponsored by the Center for Faculty Development’s Office for Well-Being

Join guest leader, Sara Lazar, PhD.

Register and add to calendar

Facebook  Twitter  Instagram