3 . How are antibodies different from vaccines?
While there are some similarities, there are three main ways in which antibodies differ from vaccines. First, when given to infected patients, these neutralizing monoclonal antibodies can transfer a type of immunity to the patient, which is referred to as passive immunity. This may help fight the infection before the immune system builds up a response to the virus, which is called adaptive immunity. Vaccines provide active immunity by helping the body make its own antibodies to protect itself. Neutralizing monoclonal antibodies also work more quickly than vaccines, but the immunity they convey is of a limited duration compared to that of vaccines. Third, scientists are able to develop antibody treatments faster than they are able to develop vaccines. For more information on treatments for COVID-19, including antibodies and vaccines, you can visit LillyAntibody.com
4 . What is the dose of a monoclonal antibody?
Doses can vary between individual neutralizing monoclonal antibodies, but are likely based on their potential clinical effect to reduce viral load and neutralize virus for a sufficient period of time.
5 . What should I do if my patient who is high-risk is symptomatic?
If you are treating a patient who is high-risk and has begun experiencing symptoms of COVID-19, an antibody treatment could be an option, and may reduce patient symptoms and/or the risk of being hospitalized. In order to be eligible for this type of treatment, patients must have tested positive for SARS-CoV-2 and be within 10 days of symptom onset. If together you and your patient decide to pursue an antibody treatment, you can find infusion centers HERE
6 . How soon after symptom onset should antibodies be administered?
Monoclonal antibody treatments should be administered within 10 days of symptom onset and before a patient has been hospitalized due to COVID-19. For more information, you can visit CombatCOVID.hhs.gov
7. How are monoclonal antibodies administered?
Monoclonal antibodies are administered through a single intravenous infusion (IV). The infusion duration will depend on the size of the prefilled IV bag that is used. Patients must be monitored for at least 60 minutes following the infusion.
8. How do I find monoclonal antibody treatments?
You can click HERE
to find an infusion site tracker by city and state.
9. How much do antibody treatments cost?
Through the federally-run distribution program, antibody treatments are purchased by the federal government and offered at no cost to states, sites of care, or patients. Services and ancillary expenses necessary to administer the infusion are the responsibility of the individual site of care and can be billed according to published Centers for Medicare & Medicaid Services (CMS) guidance
10. Does a patient need a prescription for antibody treatments?
A patient who meets the criteria for an antibody treatment will need an order from a healthcare provider. The process includes the following steps:
Step 1: The healthcare provider must confirm that the patient meets the criteria to receive an antibody treatment.
Step 2: The healthcare provider should locate a nearby infusion center.
Step 3: The healthcare provider should discuss with staff at the infusion site regarding the preferred method for prescribing treatment. In some cases, the patient’s HCP will write the order. In other cases, an HCP at the infusion site will write the order.
11. What are the possible side effects of monoclonal antibody treatments?
Neutralizing monoclonal antibody treatments authorized for emergency use by the U.S. Food and Drug Administration (FDA) are still being studied. Therefore, serious and unexpected adverse events may occur that have not been previously reported with neutralizing monoclonal antibody use. Serious hypersensitivity reactions, including anaphylaxis, have been observed with administration of neutralizing monoclonal antibodies. If signs and symptoms of a clinically significant hypersensitivity reaction or anaphylaxis occur, immediately discontinue administration and initiate appropriate medications and/or supportive therapy. For more information regarding side effects of monoclonal antibody treatments, please refer to combatcovid.hhs.gov