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multipurpose prevention technologies (MPTs)
MPT Insiders, 

This month’s issue of the MPT Insider is packed with the latest research, media, events and opportunities for you as our partners in advancing the field of multipurpose prevention technologies! We encourage you to share these resources with your networks and join us at these events. Keep scrolling to learn more! 

Thank you for your continued partnership with the IMPT, 
The Secretariat Staff  
MPT Research Articles

Multipurpose Prevention Technologies: Opportunities and Challenges to Ensure Advancement of the Most Promising MPTs. Young Holt et al. (2021). Frontiers in Reproductive Health.

Recent advances in electrospun nanofiber vaginal formulations for women's sexual and reproductive health. Cazorla Luna et al. (2021). International Journal of Pharmaceutics

Implications of advance biomaterials in development of new contraceptive devices. Kumar et al. (2021). Journal of Materials NanoScience
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel. Dallal Bashi et al. (2021). International Journal of Pharmaceutics. 
Passive immunization of the human vagina. Anderson. (2021). Human Vaccines & Immunotherapeutics. 
Long-Acting Reversible Contraception, Condom Use, and Sexually Transmitted Infections: A Systematic Review and Meta-analysis. Steiner et al. (2021). American Journal of Preventative Medicine. 
Estimating the market size for a dual prevention pill: adding contraception to pre-exposure prophylaxis (PrEP) to increase uptake. Begg et al. (2021). BMJ Sexual & Reproductive Health. 
Vaginal ring acceptability: a systematic review and meta-analysis of vaginal ring experiences from around the world. Ridgeway et al. (2021). Contraception. 

Contraceptive Technologies: Looking Ahead to New Approaches to Increase Options for Family Planning. Haddad et al. (2021). Clinical Obstetrics & Gynecology. 
MPT Technical Report
In 2019 the IMPT facilitated a process to inform strategic actions for advancing non-hormonal MPTs. A priority action area, which emerged from this process, is to identify and stimulate research for anti-infective approaches targeting HIV and other STIs that could be combined with contraceptives as MPTs.  

To further stimulate MPT innovation and connect researchers working on compounds that have the potential to become active pharmaceutical ingredients (APIs) in future MPTs, this review aims to summarize the anti-infective agents in development with activity against HIV or other STIs. See report here
MPTs in the Media
Upcoming Conferences and Key Dates

December 6-11, 2021 | 21st International Conference on AIDS and STIs in Africa (ICASA) (Virtual + Durban ICC, South Africa) 
ICASA is a major bilingual international AIDS conference, with in-person and virtual modalities. This conference represents a tremendous opportunity to highlight the diverse nature of the African region’s HIV epidemic and the unique response to it. Learn more and register here

February 12-16, 2022 | Conference on Retroviruses and Opportunistic Infections (CROI) (Virtual + Denver, USA) 
For researchers and clinical educators in the field of HIV and other retroviruses, the CROI will offer a platform to explore emerging and momentous research on these issues. This unique conference will be held both virtually and in Denver, Colorado in 2022. 
February 15-16, 2022Reproductive Health Innovation Summit (Boston, USA) 
As part of the Women’s Health Innovation Series, the Reproductive Health Innovation Summit will bring together innovators in the field to discuss solutions and the future of reproductive health, maternal health, and fertility. Register here!

May 25-28, 2022 | 16th ESC Conference (Ghent, Belgium) 
This year’s Congress of the European Society of Contraception and Reproductive Health will focus on issues of sexual violence, contraception, and STIs under the theme: “Challenging times, are we ready? Novel approaches to sexual and reproductive health.” The Call for Abstracts has been extended to November 30th! Learn more about the conference and register here.  

July 29 – August 2, 2022 | AIDS 2022 (Virtual + Montreal, Canada) 
Registration for AIDS 2022, the 24th International AIDS Conference, is now open. For the first time, the world’s largest conference on HIV and AIDS will be hosted in-person, as well as virtually, to make it accessible to as many people as possible. Pre-conference meetings begin July 27, 2022.  
November 14-17, 2022 | 6th International Conference of Family Planning (Pattaya City, Thailand) 
This conference is set to take place in Pattaya City, Thailand. This will be a stage to disseminate knowledge, celebrate successes, and identify next steps toward reaching the goal of universal access to family planning systems, services, and products. Learn more! 

Contact us if you or your colleagues are attending any upcoming meetings where MPTs will be featured. We’re happy to provide materials to help enhance your presentations. We’d also love to include any materials that you share with us from recent MPT relevant events in our MPT Resource Center
December 9, 2021 | Advocating for Gender Rights Through Self-Care for UHC
Join the IMPT and partners with the Self-Care Trailblazer Group for this community forum to discuss increasing accessibility and use of self-care for marginalized genders through health systems. Register here for this event!

Find some recently passed webinars now available on-demand!

AVAC and the AIDS Foundation of Chicago hosted this engaging event on the future of MPTs and the products closest to introduction, co-moderated by the AIDS Foundation of Chicago's Jim Pickett and the IMPT's Bethany Young Holt. This lively webinar featured expert presenters and a moving performance. If you missed it, find the recording here.
Access Passcode: +Bf%f8$2

November 16, 2021 | Contraceptive-Induced Menstrual Changes Global Research & Learning Agenda
The FHI360's CIMC Task Force gathered experts on menstrual health and family planning to discuss the new Contraceptive-Induced Menstrual Changes Global Research & Learning Agenda. Watch the official launch of this agenda here.  

November 18, 2021 | Launching FP 2030 Moving Forward Together to Transform the Future 
FP2030 held this virtual event to celebrate the next decade of the family planning movement. Watch it here!
Opportunities to be Directly Involved in MPT Development!

EvoFem is currently recruiting for participants in their clinical MPT trial. The EvoGuard Study will evaluate the safety and efficacy of EVO100 vaginal gel in the prevention of some STIs.

For those interested in playing a role in the development of new MPTs, read more about the study and eligibility criteria here.
Funding Opportunities

The following funding opportunities support research to meaningfully advance the field of MPTs. Find these and other available opportunities here.  
Multipurpose Prevention Technology (MPT): Novel Systemic Options for Young Adults (R43/R44 Clinical Trial Not Allowed) | NICHD, NIAID, NIMH 
The objective of this FOA is to support the development of innovative long-acting systemic and non-systemic MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokinetic (PK), pharmacodynamic (PD), safety and, drug-drug interactions (DDI) studies. It also encourages biobehavioral and social studies to identify MPT end user preferences (look, feel, effectiveness, safety and duration of action) and other behavioral/social factors that could promote increased MPT use in adolescent and young women. This is a R43/R44 - Small Business Innovation Research (SBIR) Grant - Phase I and Fast-Track. View the full FOA description and apply before December 9th, 2021 here 
Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R41/R42 Clinical Trial Not Allowed) | NICHD, NIMH  
The objective of this FOA is to support the development of new and innovative long-acting systemic and non-systemic MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokinetic (PK), pharmacodynamic (PD), safety and, drug-drug interactions (DDI) studies. It also encourages biobehavioral and behavioral/social studies to identify MPT end user preferences factors (look, feel, effectiveness, safety and duration of action) and other behavioral/social factors that could promote increased MPT use in adolescent and young women. This is a R41/R42 - Small Business Technology Transfer (STTR) Grant - Phase I, Fast-Track. View the full FOA description and apply before December 9th, 2021 here. 

Contraception Development Research Center Program (P50 Clinical Trial Optional) | This FOA supports and facilitates multidisciplinary approaches towards the development of new and/or improved contraceptive methods for both men and women through the formation of a Contraceptive Research Development Center. This FOA allows the inclusion of translational studies to facilitate the pre-clinical to clinical transition and increase the likelihood of clinical success. Additionally, it allows for behavioral/social science, including market research to test user acceptability, research projects that are responding and well-coordinated to the contraceptive product being developed. Applications are due December 29th, 2021; learn more and apply here
MCI-BCM Sponsored Target Screening | This ongoing funding scheme offers the opportunity to utilize state-of-the-art facilities at Baylor College of Medicine to screen validated male contraceptive targets for small-molecule inhibitors using DNA-Encoded Chemistry Technology. Learn more and apply here.
Fellowship & Career Opportunities

Looking to advance your MPT career? Keep an eye out here for updated career and fellowship opportunities.  

Gilead Public Health Research Scholars | The Global Public Health Awards support development of independent investigators from low and middle-income countries with an interest in supporting country driven research priorities to meet sustainable development goals for people infected with or at risk for viral Hepatitis (B,C,D) and/or HIV. Apply before April 15, 2022. Learn more about this opportunity here.  

Nominations for WHO Youth Council | The World Health Organization (WHO) wants to collaborate with representatives of health and non-health youth organizations on key health and development issues affecting young people to co-create a comprehensive and inclusive WHO Youth Engagement Strategy. Learn more, and get involved here

Deputy Director Position at The Well Project | The Well Project is a global leader in ending the HIV/AIDS epidemic, striving to make sure women and girls are included along the way. The organization is recruiting for their new Deputy Director position. Qualified applicants would be passionate about the mission of The Well Project, creative, and motivated. To find out more about the role and apply, visit their website. 

Call for new members of IPPF International Medical Advisory Panel | IMAP is looking for new members to join the Panel for the next 3-year term. The IMAP is seeking individuals with medical and technical expertise in SRHR including service delivery, research, health systems, medical standards and quality of care to formulate and disseminate recommendations to the IPPF and other stakeholders regarding best practices in SRHR. For more details about the IMAP terms of reference, eligibility criteria, and how to apply, visit this page
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