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Updates from Research Administration
- President's Message: Pioneering Regenerative Medicine at Lurie Children’s and Manne Research Institute
Science Showcase
- John Fortunato Receives NASPGHAN Foundation Innovation Award
- Amy Paller Recognized on Clarivate Analytics “Highly Cited” List
- FDA Awards CTIP Another Five-Year Grant to Support Pediatric Medical Device Innovation
- Renee Manworren Receives $1.2 Million National Science Foundation Grant
- Cynthia LaBella Honored With Thomas E. Shaffer, MD, FAAP Award
- FCHIP Announces Different Approaches to Data Pilot Funding Award Winners
- Jennifer Hoffmann Receives Dr. Joseph Wright Advocacy Abstract Award
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Lurie Children's November 10 Grand Rounds Feature Manne Research Institute Presenters
News from the Manne Research Institute Pillars
- More Than 1 in 10 Pediatric Ambulance Runs are for Mental Health Emergencies
- Race Among Disparities in Presentation of Adolescent Scoliosis
Manne Research Institute in the Media
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UPDATES FROM RESEARCH ADMINISTRATION | |
Office of the President and Chief Research Officer | | |
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Pioneering Regenerative Medicine at Lurie Children’s and Manne Research Institute
Manne Research Institute's latest President's Message from Dr. Patrick Seed
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Pioneering research in regenerative medicine by Youyang Zhao, PhD, Monica Laronda, PhD, and Arun Sharma, PhD, at Manne Research Institute represents the forefront of medical advancements, marking an era in medicine where regeneration and healing is a reality. In his latest President’s Message, President and Chief Research Officer Patrick Seed, MD, PhD, reaffirms Manne Research Institute’s commitment to innovative healthcare solutions through groundbreaking discoveries in scientific research. | |
John Fortunato Receives NASPGHAN Foundation Innovation Award | |
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John Fortunato, MD, Director of the Neurointestinal and Motility Program at Ann & Robert H. Lurie Children’s Hospital of Chicago, recently received the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Foundation/Takeda Pharmaceutical Products Research Innovation Award. The grant will provide $75,000 annually for two years (total $150,000) for innovative, high-impact research in pediatric gastroenterology, hepatology, and nutrition.
The funds will support Dr. Fortunato’s research investigating ways to improve diagnosis and treatment of functional gastrointestinal health conditions known as disorders of gut-brain interaction (DGBI). These are challenging for doctors to diagnose and treat because of their heterogeneous presentation and multiple biopsychosocial co-morbidities.
The purpose of the project is to incorporate the perspectives of key stakeholders through a user-centered design approach to design a method for digital capture of patient- and parent-reported information and dissemination to clinical providers. Dr. Fortunato and his collaborators—Bonnie Essner, PhD, Pediatric Psychologist with the Pritzker Department of Psychiatry and Behavioral Health at Lurie Children’s, and Andrew B.L. Berry, PhD, Assistant Professor of Medical Social Sciences (Intervention Science) at Northwestern University Feinberg School of Medicine—will identify design requirements for clinician-facing workflow and technology through observations and interviews with clinicians. They will then develop and evaluate a prototype system and establish a workflow with end-users. By the end of the project, the team will have a clear idea of the design requirements for adolescent- and parent-facing and clinician-facing interfaces to improve diagnosis and treatment of DGBI.
Pediatric research at Ann & Robert H. Lurie Children’s Hospital of Chicago is conducted through Stanley Manne Children’s Research Institute.
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Amy Paller Recognized on Clarivate Analytics “Highly Cited” List
Amy Paller, MD, Attending Physician, Dermatology, at Ann & Robert H. Lurie Children’s Hospital of Chicago, was named to the 2023 Highly Cited Researchers list published by Clarivate Analytics. The annual list identifies investigators who have shown broad and significant influence in their field of research through the publication of highly cited publications during the last decade. As a pediatric dermatologist and clinical researcher, Dr. Paller specializes in genetic and immune-mediated inflammatory in children.
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FDA Awards CTIP Another Five-Year Grant to Support Pediatric Medical Device Innovation | |
The Consortium for Technology & Innovation in Pediatrics (CTIP) has received a five-year Pediatric Device Consortia (PDC) grant from the U.S. Food and Drug Administration’s Office of Orphan Products Development. The grant will continue to support CTIP’s work to improve child health outcomes by advancing pediatric medical devices.
The grant was awarded to the team led by Juan Espinoza, MD, Director and Principal Investigator at CTIP and Chief Research Informatics Officer for Stanley Manne Children’s Research Institute at Ann & Robert Lurie Children’s Hospital of Chicago. CTIP’s leadership team includes Co-Directors Yaniv Bar-Cohen, MD, pediatric cardiologist, and Melissa Bent, MD, pediatric orthopedist, both at Children’s Hospital Los Angeles. CTIP is one of only five centers in the United States awarded a PDC grant for the 2023–2028 cycle.
“Medical devices are critical in the diagnosis and treatment of childhood diseases, but they are rarely designed, developed, tested, and approved specifically for children. The PDC program is an important component of a larger national strategy to close this pediatric health inequity,” said Dr. Espinoza. “CTIP’s mission is to help support pediatric device innovators from concept to commercialization, and to ensure that the needs of children and their families are first and foremost in the development of new technologies.”
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Renee Manworren Receives $1.2 Million National Science Foundation Grant | The National Science Foundation has awarded a $1.2 million grant award to Renee C.B. Manworren, PhD, APRN, Pediatric Clinical Nurse Specialist, Anesthesiology, and the Posy and Fred Love Chair in Nursing Research at Ann & Robert H. Lurie Children’s Hospital of Chicago, and Susan Horner, PhD, APRN-CNS, Development Specialist and Nurse Scientist, Neonatal Intensive Care Unit, at Lurie Children’s. The grant will fund the study, “Neonatal Facial Coding for Pain Recognition Monitoring System (PRAMS).” The goal of study is to advance the creation of an automated PRAMS grounded by biological evidence of pain and supervised by nurses-in-the-loop. Dr. Manworren is the study’s principal investigator. | |
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Cynthia LaBella Honored With Thomas E. Shaffer, MD, FAAP Award
Cynthia LaBella, MD, Medical Director of the Institute for Sports Medicine at Ann & Robert H. Lurie Children’s Hospital of Chicago, received the American Academy of Pediatrics Council on Sports Medicine and Fitness Thomas E. Shaffer, MD, FAAP Award. The award recognizes an individual who has made a significant contribution to the field of pediatric sports medicine by displaying leadership and vision, providing quality presentations, and publishing documents relevant to this specialty. Dr. LaBella’s research focuses on identification of risk factors for injury in youth sports and development of strategies for injury prevention.
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FCHIP Announces Different Approaches to Data Pilot Funding Award Winners | |
The purpose of the Family and Child Health Innovations Program (FCHIP) Different Approaches to Data (DAD) pilot funding is to encourage researchers to expand their work beyond a maternal-child or dyadic focus and to begin to collect pilot data that allows for a more holistic and contemporary view of families. These pilot funds can be used to expand research to include fathers (or partners) in creative ways. For the third round of DAD pilot funding, FCHIP is pleased to announce the winners for 2023: John James Parker, MD, MS, and Soyang Kwon, PhD.
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Jennifer Hoffmann Receives Dr. Joseph Wright Advocacy Abstract Award | | |
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The American Academy of Pediatrics Section on Emergency Medicine recently presented Jennifer Hoffmann, MD, MS, Attending Physician, Emergency Medicine, at Ann & Robert H. Lurie Children’s Hospital of Chicago, with the inaugural Dr. Joseph Wright Advocacy Abstract Award for her abstract on “Pediatric Firearm Injury Emergency Department Visits during the COVID-19 Pandemic: A Multicenter Study.” Dr. Hoffmann, who is also the Children’s Research Fund Junior Board Research Scholar at Lurie Children’s, conducts health services research using large databases to understand emergency department utilization patterns and disparities in pediatric mental health conditions. | |
Lurie Children's November 10 Grand Rounds Feature Manne Research Institute Presenters | |
Researchers from Manne Research Institute presented "Translational Research: Applying Lessons from the COVID-19 Pandemic to Improve Child Health" at Lurie Children's Grand Rounds on November 10.
Presenting researchers included (pictured from left to right) Leena B. Mithal, MD, Bria Coates, MD, Marie Heffernan, PhD, and William J. Muller, MD, PhD. They are joined in the photo by Susanna McColley, MD.
Topics included an exploration of assays available to identify host-pathogen relationships associated with severity of illness in viral respiratory infections; challenges in enhancing access to clinical trials in healthy children; the message characteristics that promote parents’ COVID-19 vaccination intentions for their children; and advances in research methodology enabling molecular and developmental perinatal studies.
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NEWS FROM THE RESEARCH PILLARS | |
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A new study offers a novel look at the scope of the youth mental health crisis across the United States – in 2019-2020, more than 1 in 10 kids who were brought to the hospital by ambulance had a behavioral health emergency. Out of these behavioral health emergencies, 85 percent were in 12-17-year-olds. Findings were published in the journal Academic Emergency Medicine.
“Our study found that pediatric behavioral health emergencies requiring an ambulance were much too frequent,” said senior author Jennifer Hoffmann, MD, MS, emergency medicine physician at Ann & Robert H. Lurie Children’s Hospital of Chicago and Assistant Professor of Pediatrics at Northwestern University Feinberg School of Medicine. “And yet, there are no national guidelines for EMS personnel to manage these patients. We found considerable variation in the use of sedative medications and restraints across different parts of the country. There is a great need for standardized EMS protocols for pediatric behavioral health emergencies. Currently only four states have these available.”
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Black/African American adolescents were more than twice as likely as their White peers to be diagnosed with severe scoliosis in a study led by researchers at Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.
The retrospective cross-sectional study, published in the Journal of the Pediatric Orthopaedic Society of North America (JPOSNA), included patients aged 10-18 diagnosed with idiopathic scoliosis (curvature of the spine) in the Chicago area between 2011-21.
Researchers, including senior author Jill Larson, MD, a Lurie Children’s pediatric orthopedic surgeon, found that race, in addition to type of insurance, gender and Child Opportunity Index factors (COI) affected whether a child referred to a pediatric orthopedic surgeons had a mild or more severe scoliosis (defined as a curve of 40 degrees or more). The COI is a validated neighborhood-level index score derived from 29 independent indicators that are known to affect children’s health and development, such as poverty rate and access to healthy food.
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MANNE RESEARCH INSTITUTE IN THE MEDIA | | | | |
