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Updates from Research Administration
- President's Message: Three Cheers for Surpassing a Manne Research Institute Milestone
- In Pursuit Podcast: Researching the Barriers to Swim Safety in the City
Science Showcase
- Three Faculty Recognized at Investiture Ceremony
- Kyle MacQuarrie Receives Major Gift from the Pediatric Cancer Research Foundation
News from the Manne Research Institute Pillars
- Emergency Departments Saw Firearm Injuries in Children Double During Pandemic
- Higher Parenting Stress for Dads Working from Home During Pandemic
- Botox Improves Chronic Nausea and Vomiting in Children with Disorder of Gut-Brain Interaction
Manne Research Institute in the Media
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UPDATES FROM RESEARCH ADMINISTRATION | |
Office of the President and Chief Research Officer | | |
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Three Cheers for Surpassing a Manne Research Institute Milestone
Manne Research Institute's latest President's Message from Dr. Patrick Seed
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Stanley Manne Children's Research Institute and Ann & Robert H. Lurie Children's Hospital of Chicago have surpassed a goal of $100 million in extramural research funding two years ahead of schedule. In his latest President's Message, Dr. Patrick Seed celebrates how innovative, collaborative research teams, together with passionate supporters in the medical center executive team, the foundation, board members, and donors, made this ambitious goal a reality. This funding milestone represents what matters most—the realization of vision, which involves extensive research, discovery, and innovation in pediatric health. To continue the momentum and tackle the most audacious health challenges, we will continue to invest in the support for science, expand and diversify our team, and refine and reconstruct the processes. | |
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Researching the Barriers to Swim Safety in the City
Latest In Pursuit podcast features Dr. Michelle Macy and is hosted by Dr. Patrick Seed
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In the latest episode of In Pursuit, host Patrick Seed, MD, PhD, discusses with Michelle Macy, MD, MS, the genesis of her research into child water safety and injury prevention, as well as the risk factors that contribute to accidental drowning. Dr. Macy also explores the deep-rooted, historical barriers to swim safety in Chicago, and shares how research can guide our response to this alarming public health and safety issue. | |
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Three Faculty Recognized at Investiture Ceremony | |
Stanley Manne Children’s Research Institute congratulates the following research institute faculty who were honored at this month's investiture ceremony. Investiture ceremonies recognize and celebrate the accomplishments of honorific position holders and the donors who have made these positions possible through their enduring investments. | |
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James W. Collins, Jr., MD, MPH
Zeisler Family Neonatology Leadership Chair
Established in 2019 and generously supported by Karen Zeisler, and Karl and Joan Zeisler
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Mary E. Robbins, MD
Neal, Kathleen and Adam Kulick Endowed Research Scholar in Neonatology
Established in 2021 and generously supported by Neal and Kathleen Kulick
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Daniel T. Robinson, MD
Founders' Board Neonatology Young Research Scholar
Established in 2005 and generously supported by the Founders' Board
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Thanks to the generosity of generations of donors, Ann & Robert H. Lurie Children’s Hospital of Chicago is home to more than 70 donor-funded, honorific positions that recognize the clinical accomplishments, scholarship, and research of our faculty and staff. These prestigious positions have been established to advance the hospital’s mission across the four pillars of care, research, advocacy, and education. They convey a great honor for both the individuals who hold them, and for those who establish and name them through enduring investments. | |
Kyle MacQuarrie Receives Major Gift from the Pediatric Cancer Research Foundation | |
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The Pediatric Cancer Research Foundation recently presented a major gift to Kyle MacQuarrie, MD, PhD, an attending physician at Ann & Robert H. Lurie Children’s Hospital of Chicago, to investigate treatment resistance of rhabdomyosarcoma, a rare and aggressive pediatric cancer of the muscle.
Treatment for rhabdomyosarcoma includes chemotherapy along with surgical removal of the tumors, radiation therapy to the tumors, or both. While some patients respond well to the treatments and are essentially cured, others experience a relapse with tumors that are much more resistant to treatments. The major gift will support Dr. MacQuarrie’s research on how chromosomal organization in rhabdomyosarcoma cells affects tumor resistance to chemotherapy, with the hopes of identifying ways to sensitize resistant tumor cells to chemotherapy and improve the treatment of children diagnosed with these types of tumors.
Dr. MacQuarrie is the Sharon B. Murphy, MD and Steven T. Rosen, MD Research Professorship in Cancer Biology & Chemotherapy at Lurie Children’s, and an assistant professor of pediatrics at Northwestern University Feinberg School of Medicine. Pediatric research at Lurie Children’s is conducted through Stanley Manne Children’s Research Institute.
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NEWS FROM THE RESEARCH PILLARS | |
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Pediatric Emergency Department (ED) visits for firearm injuries doubled during the pandemic compared to earlier trends, according to a multicenter study published in the journal Pediatrics. During this time, deaths from firearm injuries in children and adolescents that occurred after arrival to the hospital also doubled – up from 3 percent of ED visits pre-pandemic to 6 percent of ED visits during the pandemic.
“With the pandemic we saw a drastic increase in firearm purchases, which might have led to the tragic spikes in injuries and deaths from firearms among children and adolescents,” said lead author Jennifer Hoffmann, MD, MS, pediatric emergency medicine physician at Ann & Robert H. Lurie Children’s Hospital of Chicago and Assistant Professor of Pediatrics at Northwestern University Feinberg School of Medicine.
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A survey from Ann & Robert H. Lurie Children’s Hospital of Chicago found that 40 percent of parents who worked remotely during the pandemic reported higher parenting stress compared with only 27 percent of parents who worked onsite.
Results revealed a gender difference – fathers who worked from home were twice as likely to report that parenting was stressful all or most of the time compared to fathers who worked onsite. Parenting stress for mothers who worked at home was slightly higher, but it did not reach statistical significance.
The study found no differences in mental or general health between parents who worked remotely or onsite.
“Our survey results show that teleworking during the pandemic was associated with more parenting stress, especially for fathers,” said lead author John James Parker, MD, a pediatrician at Lurie Children’s, an internist at Northwestern Medicine and Assistant Professor of Pediatrics at Northwestern University Feinberg School of Medicine. “This might be a reflection of societal expectations that men should prioritize work obligations over family needs, which creates additional stress for fathers working from home. We recommend that parents reflect on their family and work situation and try to find an arrangement that limits stress and promotes wellbeing. This can be as simple as putting a noise cancelling machine in the workspace, rearranging schedules to limit distractions and planning time for parents to step away from work to be fully engaged with their children.
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A study from Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that Botulinum toxin (Botox) injected in the pylorus (sphincter where the stomach exits into the small intestine) during endoscopy improves chronic nausea and vomiting in children who have a disorder of gut-brain interaction (DGBI). These debilitating symptoms not attributed to a defined illness have previously been called functional gastrointestinal disorders before the newer DGBI classification. The study’s findings point to a novel understanding of the condition’s pathology – pylorus that is failing to relax and allow food to effectively pass into the small intestine resulting in symptoms of nausea, vomiting, stomach fullness (early satiety), and bloating. Results were published in the Journal of Pediatric Gastroenterology and Nutrition.
“Our results suggest that chronic nausea and vomiting might be caused by pyloric dysfunction, rather than abnormal peristalsis, which is the rhythmic contraction and relaxation of digestive tract muscles needed to move foods and liquids through the gastrointestinal system,” said lead author Peter Osgood, MD, gastroenterologist at Lurie Children’s and Assistant Professor of Pediatrics at Northwestern University Feinberg School of Medicine. “This is a paradigm shift in our understanding of mechanistic pathology. Importantly, it opens the door to a more targeted use of Botox specifically in children who are found to have pyloric dysfunction during endoscopy, and for whom the current medications are not effective.”
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MANNE RESEARCH INSTITUTE IN THE MEDIA | | | | |
