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Manne Research Institute's President's Message
- Collaboration in Action: The Power of Our Team-Driven Research
Science Showcase
- Manne Research Institute Names Spring 2024 Internal Funding Awardees
- Debra Weese-Mayer Receives $1.6M FDA Grant Award
- NIH Grant to Tackle Access to Youth Knee Injury Care in Chicago Hispanic Community
News from the Manne Research Institute Pillars
- Nonfatal Opioid Overdoses in Youth Spiked During Pandemic
- Kids Miss Out on Learning to Swim During Pandemic, Widening Racial and Ethnic Disparities
- 20-Week Ultrasound in Pregnancy is a Key Driver of Disparities in Prenatal Diagnosis of Congenital Heart Defects
Manne Research Institute in the Media
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Collaboration in Action: The Power of Our Team-Driven Research
Two years ago, the first Manne Research Institute President’s Message was shared to celebrate teamwork as our superpower. Teams comprising innovative and creative individuals from both inside and outside the research institute are the lifeblood of our collaborative community, propelling research advancements forward. In his latest message, President and Chief Research Officer Patrick Seed, MD, PhD, FIDSA, reflects on two years of messages and celebrates how the power of our teamwork is elevating the importance of pediatric medical research and ensuring better health outcomes for children.
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Manne Research Institute Names Spring 2024 Internal Funding Awardees | Stanley Manne Children’s Research Institute announces the recipients of the spring 2024 internal funding opportunities. Manne Research Institute provides internal grant and award opportunities to a faculty member or other person who has principal investigator-eligible status to develop projects that will lead to a highly competitive extramural application for sustained research support within 18 months of receiving the award. Funding opportunities are available bi-annually, in the spring and fall, and may vary depending on the year and cycle. Pediatric research at Ann & Robert H. Lurie Children’s Hospital of Chicago is conducted through Stanley Manne Children’s Research Institute | |
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Eric Cheon, MD
Attending Physician, Anesthesiology, Ann & Robert H. Lurie Children’s Hospital of Chicago; Associate Professor of Anesthesiology (Pediatric Anesthesiology), Northwestern University Feinberg School of Medicine
Award type: Device and Informatics Springboard Award
Amount funded: $25,000
Title: A Dually Deployed Wireless, Wearable Monitor System for the Detection of Intraoperative Airway Obstruction in Children Undergoing Tonsillectomies
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Sean DeLacey, MD
Attending Physician, Endocrinology, Ann & Robert H. Lurie Children’s Hospital of Chicago; Assistant Professor of Pediatrics, Northwestern University Feinberg School of Medicine
Award type: Endocrine Pilot Project Grant—Preparatory Award
Amount funded: $4,985
Title: Post-Transition Type 2 Diabetes Experience and Outcomes
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Bonnie Essner, PhD
Pediatric Psychologist, The Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children’s Hospital of Chicago; Assistant Professor in Psychiatry and Behavioral Sciences (Child Psychology) and Pediatrics, Northwestern University Feinberg School of Medicine
Award type: Pritzker Pilot Research Award
Amount funded: $40,000
Title: Multi-Method Assessment of Interoceptive Abilities, Mindfulness, and Health Outcomes Among Adolescents with Abdominal Pain-Disorders of Gut-Brain Interaction (AP-DGBIs)
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Ariela Kaiser, PhD
Post-Doctoral Associate, The Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children’s Hospital of Chicago
Award type: Pritzker Department of Psychiatry and Behavioral Health Research Pilot Award—Trainee Pilot Research Award
Amount funded: $5,000
Title: Enhancing Caregiver Preparedness for Family-Based Treatment of Anorexia Nervosa: A Pilot Study of the Empower-ED Single-Session Intervention
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Xiao-Nan Li, MD, PhD
Rachelle and Mark Gordon Professor of Cancer Research, Ann & Robert H. Lurie Children’s Hospital of Chicago; Professor, Pediatrics (Hematology, Oncology, and Stem Cell Transplantation), Northwestern University Feinberg School of Medicine
Award type: Proposal Revision Award
Amount funded: $100,000
Title: Mechanistic Outcomes of Selective Targeting of ZFTA::RLA Fusion Gene in Pediatric Ependymomas
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Hannah McDowell
Graduate Student, Driskill Graduate Program in Life Sciences, Northwestern University Feinberg School of Medicine
Award type: Mary J.C. Hendrix Outstanding Graduate Student Award
Amount funded: $5,000
Title: Elucidating the Mechanism by which Elastin Microfibril Interface-located Protein 1 (EMILIN 1) Contributes to Folliculogenesis
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Jillian Merrick
Breakthrough T1D Diabetes Psychology Fellow, The Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children’s Hospital of Chicago
Award type: Pritzker Department of Psychiatry and Behavioral Health Research Pilot Award—Trainee Pilot Research Award
Amount funded: $5,000
Title: Risk and Protective Factors for Optimal Health Outcomes in Children with Type 1 Diabetes (T1D) and their Caregivers
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Divakar S. Mithal, MD, PhD
Attending Physician, Neurology, Ann & Robert H. Lurie Children’s Hospital of Chicago; Founders’ Board Chair in Neurocritical Care, Lurie Children’s; Assistant Professor of Pediatrics (Neurology and Epilepsy), Northwestern University Feinberg School of Medicine
Award type: Kenneth C. Griffin Research Catalyst Award
Amount funded: $100,000
Title: Restoring Metabolism in Patient-Derived Stem Cells to Treat Mitochondrial Disease
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Elizabeth Moroney, PhD and Laurie Thompson, PhD
Moroney (top photo): Pediatric Psychologist, The Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children’s Hospital of Chicago; Assistant Professor of Psychiatry and Behavioral Sciences (Child Psychology), Northwestern University Feinberg School of Medicine
Thompson (bottom photo): Pediatric Psychologist, The Pritzker Department of Psychiatry and Behavioral Health, Ann & Robert H. Lurie Children’s Hospital of Chicago; Assistant Professor of Psychiatry and Behavioral Sciences (Child Psychology), Northwestern University Feinberg School of Medicine
Award type: Pritzker Department of Psychiatry and Behavioral Health Research Pilot Award—Early Career Faculty Pilot Research Award
Amount funded: $20,000
Title: Translating Emerging Diagnostic Criteria into a Valid and Acceptable Clinical Tool for the Diagnosis of Functional Tic-Like Behaviors in Youth
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L. Nelson Sanchez-Pinto, MD, MBI, FAMIA
Attending Physician, Critical Care, Ann & Robert Lurie Children’s Hospital of Chicago; Warren and Eloise Batts Research Scholar, Lurie Children’s; Associate Professor of Pediatrics (Critical Care) and Preventive Medicine (Health and Biomedical Informatics), Northwestern University Feinberg School of Medicine
Award type: Interdisciplinary Colloquia Award
Amount funded: $5,000
Title: Delivering Human-centered AI for Patient Safety: The Role of AI, Implementation Science, and Human-centered Design in Improving Patient Safety
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Abigail Schwaede, MD
Attending Physician, Neurology, Ann & Robert H. Lurie Children’s Hospital of Chicago; Assistant Professor of Pediatrics (Neurology and Epilepsy), Northwestern University Feinberg School of Medicine
Award type: Interdisciplinary Colloquia Award
Amount funded: $4,600
Title: A Multidisciplinary Approach to Improving Diagnostic Accuracy for Charcot-Marie Tooth in Patients Presenting with Pes Cavus Foot Deformity
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Arun Sharma, PhD
Director, Pediatric Urological Medicine and Surgical Research, Ann & Robert H. Lurie Children’s Hospital of Chicago and Stanley Manne Children’s Research Institute
Award type: Proposal Revision Award
Amount funded: $100,000
Title: Bivalent Supramolecular Nanotherapeutics to Treat Chronic Inflammation
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Laura Torchen, MD, MS
Attending Physician, Endocrinology, Ann & Robert H. Lurie Children’s Hospital of Chicago; Associate Professor of Pediatrics (Endocrinology), Northwestern University Feinberg School of Medicine
Award type: Endocrine Pilot Project Grant—Launch Award
Amount funded: $19,750
Title: Human Milk Macronutrient and Hormone Profiles in Mothers with PCOS
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Debra Weese-Mayer Receives $1.6M FDA Grant Award | |
The US Food and Drug Administration Office of Orphan Products Development recently awarded Debra Weese-Mayer, MD, a $1.6 million, four-year, natural history study grant for a prospective study in congenital central hypoventilation syndrome (CCHS). The research study, which will bring together international centers of excellence, patient advocacy groups, and industry partners currently working on interventions for CCHS, aims to define clinical, functional, and quality of life assessments to inform the development of effective treatment measures for this complex disease that entails a life-threatening inability to regulate breathing, requiring life-long ventilatory support.
Pediatric research at Ann & Robert H. Lurie Children’s Hospital of Chicago is conducted through Stanley Manne Children’s Research Institute.
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NIH Grant to Tackle Access to Youth Knee Injury Care in Chicago Hispanic Community
Knee injuries, especially those related to the anterior cruciate ligament (ACL) or meniscus, are a common problem among young athletes and sometimes surgery is required to treat them. Unfortunately, many kids, especially those from Hispanic communities face significant delays in getting the care they need. These delays can have serious long-term consequences, such as arthritis and chronic pain.
Lurie Children’s orthopedic surgeon-scientist Dr. Neeraj Patel is working to change this. His latest research aims to understand why these delays happen and to develop solutions to get young athletes the care they need faster to avoid long-term health issues. Learn more.
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NEWS FROM THE RESEARCH PILLARS | |
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Drug overdose mortality has risen faster among adolescents than the general population in recent years, largely due to fentanyl, a potent opioid pain medication. A new study published in JAMA sheds light on trends in nonfatal opioid overdoses in youth – an area that was not as well characterized, but key to formulating prevention strategies to save lives.
Researchers from Ann & Robert H. Lurie Children’s Hospital of Chicago and colleagues analyzed data using Emergency Medical Services (EMS) encounters from January 2018 to December 2022. They found that opioid overdoses in youth increased at pandemic onset and remained elevated compared to pre-pandemic levels. The majority (86 percent) occurred in young adults in the 18-24 age group. Adolescents aged 12-17, however, also emerged as high-risk, with significantly increasing trends both before and during the pandemic. Most of the opioid overdoses in youth (58 percent) happened at home.
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Nearly three out of four kids in Chicago had no swimming lessons in summer of 2022, with significant racial and ethnic differences, according to a parent survey from Ann & Robert H. Lurie Children’s Hospital of Chicago published in Pediatrics. Black and Hispanic/Latine kids were disproportionately affected (85 percent and 82 percent, respectively), compared to white kids (64 percent).
The most common reasons for not getting swimming lessons also differed among racial and ethnic groups. Parents of White kids reported they already knew how to swim, however Black and Hispanic/Latine parents reported being not comfortable with swimming themselves as a reason their kids did not take swimming lessons. All groups cited cost as a barrier to swimming lessons.
Racial and ethnic differences in learning to swim have been documented among adults. According to the report from the Centers for Disease Control and Prevention (CDC) released in May 2024, two out of three Black adults (63 percent) and three out of four Hispanic/Latine adults (72 percent) never had a swimming lesson, compared to less than half of White adults (48 percent). The CDC report stresses the importance of accessible basic swimming and water safety skills training, a proven and effective way to prevent drowning.
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In a recent episode of Manne Research Institute's In Pursuit podcast, host Patrick Seed, MD, PhD, discusses with Michelle Macy, MD, MS, the genesis of her research into child water safety and injury prevention, as well as the risk factors that contribute to accidental drowning. | | |
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Patients insured by Medicaid are less likely to get prenatal diagnosis of heart defects than those with private insurance, and this disparity can be partly attributed to lower rates of 20-week ultrasound in pregnant people with public insurance, according to a study led by Ann & Robert H. Lurie Children’s Hospital of Chicago in collaboration with Advocate Christ Children’s Hospital. The study was published in the journal Prenatal Diagnosis.
“The 20-week ultrasound is hugely important in detecting birth defects because it involves assessment of the baby’s major organs. All pregnant people must know that this test should not be missed,” said lead author Joyce Woo, MD, MS, pediatric cardiologist at Lurie Children’s and Assistant Professor of Pediatrics and Medical Social Sciences at Northwestern University Feinberg School of Medicine. “It is a routine part of prenatal care that is covered by Medicaid, but patients can still experience barriers to getting this test, such as inability to take time off work. Our study suggests that one way to increase rates of prenatal diagnosis of heart defects and mitigate insurance-related disparities, is to increase utilization of 20-week ultrasound.”
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