-Study characteristics: 20,250 persons included. 70% women. Prescribed agents included sulfamethoxazole, thiazides, and loop diuretics. Further population characteristics were lacking.
-Including all-comers, 5% reported a hypersensitivity reaction after sulfonamide antimicrobial ingestion and 2% after receipt of a sulfonamide nonantimicrobial.
-Among those who tolerated the sulfa antimicrobial, 1.5% reported a reaction to the ensuing sulfa nonantimicrobial. Among t
hose with an allergic reaction to the sulfa antibiotic, 10% exhibited a hypersensitivity response when given a sulfa nonantibiotic.
-If an individual tolerated the sulfa
antimicrobial, she had a 2% chance of experiencing an allergy to penicillin. If she developed a reaction to the sulfa antibiotic, there was a
14% chance of having a similar reaction to penicillin.
-These associations was preserved after adjusting for confounders.