Influence of Prior SARS-CoV-2 Infection on COVID-19 Severity: Evidence from the National COVID Cohort Collaborative

As SARS-CoV-2 has transitioned from a pandemic to endemic disease, the majority of new infections have been among previously infected individuals. To manage the risks and benefits of ongoing COVID-19 policies, it is important to understand whether prior infection modifies the severity of subsequent infections.

Datavant Joins NSF and Partners in Launch of the National AI Research Resource (NAIRR) Pilot Providing Privacy-Preservation Technologies to Safeguard AI-Enabled Data

In collaboration with 11 federal agencies, alongside private sector, nonprofit, and philanthropic organizations, the NAIRR pilot is set to offer U.S.-based researchers and educators access to cutting-edge computing, datasets, models, software, training, and user support. 

Effect of Paxlovid Treatment on Long COVID Onset: An EHR-Based Target Trial Emulation from N3C

Preventing and treating post-acute sequelae of SARS-CoV-2 infection (PASC), commonly known as Long COVID, has become a public health priority. In this study, we examined whether treatment with Paxlovid in the acute phase of COVID-19 helps prevent the onset of PASC.

N3C Data Help Validate Two Clinical Tools to Predict COVID-19 Mortality Risk

For people hospitalized with COVID-19, two new risk-prediction tools, tested in part using the NCATS National COVID Cohort Collaborative (N3C), could help clinicians make faster, better treatment decisions.

Privacy‐preserving record linkage across disparate institutions and datasets to enable a learning health system: The national COVID cohort collaborative ( N3C ) experience

Introduction Research driven by real‐world clinical data is increasingly vital to enabling learning health systems, but integrating such data from across disparate health systems is challenging.

The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia

Although vaccines have proved effective to prevent severe COVID-19, their effect on preventing long-term symptoms is not yet fully understood.

Palantir Partners with University of Colorado Anschutz Medical Campus to Establish the All of Us Research Program’s Center for Linkage and Acquisition of Data (CLAD)

Palantir Technologies Inc. (NYSE: PLTR) today announced its partnership with the University of Colorado Anschutz Medical Campus to establish the Center for Linkage and Acquisition of Data (CLAD) as part of the National Institutes of Health’s (NIH) All of Us Research Program.

Privacy-preserving record linkage across disparate institutions and datasets to enable a learning health system: The national COVID cohort collaborative (N3C) experience

Research driven by real-world clinical data is increasingly vital to enabling learning health systems, but integrating such data from across disparate health systems is challenging. As part of the NCATS National COVID Cohort Collaborative (N3C), the N3C Data Enclave was established as a centralized repository of deidentified and harmonized COVID-19 patient data from institutions across the US. 

Doctors Aren’t Prescribing Paxlovid Often Enough. Here’s Why

Covid-19 infections and deaths have been steadily increasing in recent weeks, now reaching 1,500 deaths per week. There are antiviral drugs that still protect against severe infection and death, yet practitioners prescribe them infrequently. Why?

Drug-drug interaction between dexamethasone and direct-acting oral anticoagulants: A nested case-control study in the National COVID Cohort Collaborative (N3C)

Objective The goal of this work is to evaluate if there is an increase in the risk of thromboembolic events (TEEs) due to concomitant exposure to dexamethasone and apixaban or rivaroxaban.

Severe covid-19 infections linked to increased risk of schizophrenia

People with severe covid-19 infections are more than 4 times as likely to later be diagnosed with schizophrenia than people who have not been infected, though the risk of developing the condition is relatively low.