Today's Journal Club
The February 25 Journal Club will feature the paper:
"Arterialization requires the timely suppression of cell growth"
Authors: Wen Luo, Irene Garcia-Gonzalez, Macarena Fernández-Chacón, Verónica Casquero-Garcia, Maria S Sanchez-Muñoz, Severin Mühleder, Lourdes Garcia-Ortega, Jorge Andrade, Michael Potente, Rui Benedito
Nature 589, 437–441 (2021).
The overview of the paper will be presented by Ziqing Liu, University of North Carolina at Chapel Hill and the session will be moderated by Education Committee Member, William Hughes from the Medical College of Wisconsin.
Journal Clubs are limited to active/current NAVBO members. The registration link can be found in the NAVBO Events app and has been sent to members via email. You can also post comments, questions, etc. in the Journal Club Chat on the home screen of the app.
Consider joining us!
ASIP Welcomes NAVBO to EB2021
You will especially want to attend the NAVBO sponsored session, organized by William Muller, Northwestern University, and titled - The “Ins” and “Outs” of Vascular Inflammation. Taking place on Tuesday, April 27 from 2:00 to 5:00pm EST. Presentations include:
Mechanisms of Integrin Activation During Neutrophil Arrest
Klaus Ley, La Jolla Institute for Allergy and Immunology
Endothelial Cell Regulation of Transendothelial Migration: New Roles for Old Friends
Bill Muller, Northwestern University
Neutrophil Reverse Transmigration: Mechanisms and Significance
Sussan Nourshargh, Barts and The London School of Medicine
Resolution of Inflammation in Atherosclerosis
Ira Tabas, Columbia University
Presentations will be followed by a discussion involving audience members and speakers to put these findings into context with each other and with other developments in the field.
Please join us!
NAVBO members can attend Experimental Biology 2021 as guests of the American Society for Investigative Pathology.
Register for the meeting here
Guillermo Oliver of Northwestern University has been Named the 2021 Earl P. Benditt Awardee
Dr. Oliver will present his lecture, Prox1 and lymphatics, a personal perspective, at Vascular Biology 2021 on October 24.
Congratulations, Dr. Oliver!!
For more information about Dr. Oliver and the Earl P. Benditt Award, follow the link below:
Carlos Fernandez-Hernando is the 2021 Judah Folkman Award in Vascular Biology Recipient
Dr. Fernandez-Hernando will present his lecture, Endothelial dysfunction in coronavirus induced cardiopulmonary disease, at VB2021 on October 27.
Congratulations, Dr. Fernandez-Hernando!
On March 4 at 1:00pmET, we will welcome Dr. Guillermo Oliver of Northwestern University. His presentation is titled, "The lymphatic vasculature: developmental mechanisms and functional roles."
Join us on March 9 for a special webinar, sponsored by the NAVBO Diversity, Equity and Inclusion Committee.
This webinar marks the inaugural event in the Diversity Committee's online series. Look for more webinars, round tables and workshops.
Our guest speaker, Dr. Richard Reddick, is the Inaugural Associate Dean for Equity, Community Engagement, and Outreach for the College of Education at The University of Texas at Austin. He is also Professor in the Program in Higher Education Leadership in the Department of Educational Leadership and Policy (ELP) at The University of Texas at Austin, where he has served as a faculty member since 2007. Additionally, Dr. Reddick serves as the Assistant Director of the Plan II Honors Program in the College of Liberal Arts. Dr. Reddick is a faculty member by courtesy in the Department for African and African Diaspora Studies, the John L. Warfield Center for African and African American Studies, and a fellow at the Institute for Urban Policy Research and Analysis. Dr. Reddick co-chairs the Council for Racial and Ethnic Equity and Diversity (CREED), serves on the Signature Course Advisory Committee (SCAC), and was named to the inaugural cohort of the Provost’s Distinguished Service Academy. Dr. Reddick is the faculty co-chair for the Institute for Educational Management (IEM) at Harvard University, and teaches in the Institute for Management Leadership in Education. In spring 2018, Dr. Reddick was appointed as a Visiting Associate Professor at the Harvard Graduate School of Education.
Please join us for this special inaugural session!
Join us for our webinar on April 1 at 1:00pmET featuring Dr. Karen Hirschi, University of Virginia. Her presentation is titled "Regulation of Endothelial Cell Specialization"
For more details and to register,
Join us on March 11 at 1:00pmEST for our First Focus Session on Development moderated by Siqi Gao, University of Pennsylvania and featuring four short talks from selected Vascular Biology 2020 abstracts.
- Hematopoietic potential of the endocardium in zebrafish embryos (Dr. Suman Gurung, University of South Florida)
- Unc5b is a genetic target of Notch signaling and a potential effector of Notch-mediated angiogenesis (Dr. Qanber Raza, University of Illinois at Chicago)
- Peritoneal macrophages regulate vascular integrity and erythrocyte uptake by lymphatics in the embryonic omentum (Dr. Matthew Menendez, Oklahoma Medical Research Foundation)
- Characterizing the in vivo role of RHOA signaling in regulating vascular integrity and development (Dr. Laura Pillay, NIH)
Join future Focus Sessions, sponsored and organized by the NAVBO Online Program Committee, in Signals that Control Angiogenesis, Lymphangiogenesis and Vascular Remodeling; Inflammation; Disease; New Techniques; and Endothelium Heterogeneity.
The NAVBO Education Committee reached out to interview several senior members of the Vascular Biology community to get their thoughts on a variety of key questions regarding how they pursue their science and choices they have made along their paths to professional success. We will be providing regular installments of the diverse perspectives from different individuals to share how some of our Vascular Biology Leaders have learned some of their Lessons. This will be an ongoing series and we hope to connect with more Leaders in the future!
In this issue, we asked Senior Scientists to respond to the question:
How do you stay efficient with splintered time?
Victoria Bautch, Ph.D.,
Beverly Long Chapin Distinguished Professor, Department of Biology, University of North Carolina at Chapel Hill;
Co- Director of McAllister Heart Institute
Michelle Bendeck, Ph.D.
Professor, Department of Laboratory Medicine and Pathobiology
University of Toronto;
Translational Biology and Engineering Program
Ted Rogers Centre for Heart Research.
Joyce Bischoff, Ph.D.,
Professor of Surgery, Harvard Medical School; Research Associate, Surgery,
Boston Children's Hospital;
Surgery and Vascular Biology Program,
Boston Children's Hospital
Patricia D’Amore, Ph.D.
Senior Scientist, Schepens Eye Research Institute;
Director, Howe Laboratory;
Associate Chief for Opthalmology Basic and Translational Research, Massachusetts Eye and Ear Institute;
Charles L. Schepens Professor of Ophthalmology, Harvard Medical School
Jan Kitajewski, Ph.D.
Professor and Head,
Department of Physiology and Biophysics, College of Medicine at Chicago;
Director, University of Illinois Cancer Center
Shulamit Levenberg, Ph.D.
Professor and Former Dean,
Biomedical Engineering Department
Director, Stem Cell and Tissue Engineering Laboratory,
Technion, Israel Institute of Technology,
Robert Mecham, Ph.D.
Alumni Endowed Professor,
Cell Biology and Physiology,
Professor of Medicine, Pediatrics and Bioengineering,
Washington School of Medicine in St. Louis.
Lab of the Month - February 2021
The Lab of Dr. Clint Miller
Spotlight on Trainees (from February 11 issue)
NIH studies eventual grant success of T32 Postdoctoral trainees
In his February 1 Open Mike blog post
, NIH OER Director Michael Lauer summarized career development grant outcomes of more than 35,000 T32 trainees who began their postdoctoral training between 1995 and 2009 after receiving an MD, MD-PhD, or PhD degree. Among all trainees followed, 12%, served as PI on an R01-equivalent award during the follow-up period. Of those who served as PI on a K award, a striking 42%, later served as PI on an R01-equivalent award. Conversely, among those who were not PIs on a K award, only 8% later served as PI on an R01-equivalent award. The detailed report further breaks down the findings according to gender and other characteristics.
Summer Training for Junior Faculty
Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE)
The PRIDE Summer Institute Program in Cardiovascular Disease Comorbidities, Genetics and Epidemiology to Increase Diversity Among Individuals Engaged in Health-Related Research is now accepting applications. Space is limited for the 2021 mentored summer training programs so apply early!
Eligible applicants are junior-level faculty or scientists with a background that is under-represented in the biomedical or health sciences, and are United States Citizens or Permanent Residents. Research interests should be compatible with those of the National Heart, Lung, and Blood Institute (NHLBI) in the prevention and treatment of heart, lung, blood, and sleep (HLBS) disorders.
Our All-Expense paid Summer Institute program with effective mentored training opportunities to enhance the research skills and to promote the scientific and career development of trainees with a research interest in Cardiovascular disease Comorbidities, Genetics and Epidemiology.
Trainees will learn effective strategies for preparing, submitting and obtaining external grant funding for research, including extensive tips on best practices.
Welcome to our New Members:
Xinming Liu, Washington University in St. Louis
Ana Valentin, Florida International University
Yu Zhang, Johns Hopkins University
Recent Publications by NAVBO Members
High Endothelial Venules Accelerate Naive T Cell Recruitment by Tumor Necrosis Factor-Mediated R-Ras Upregulation
The American Journal of Pathology
Recruitment of naive T cells to lymph nodes is essential for the development of adaptive immunity. Upon pathogen infection, lymph nodes promptly increase the influx of naive T cells from the circulation in order to screen and prime the T cells. The precise contribution of the lymph node vasculature to the regulation of this process remains unclear. Read more
NOGOB receptor–mediated RAS signaling pathway is a target for suppressing proliferating hemangioma
Journal of Clinical Investigation Insight
Infantile hemangioma is a vascular tumor characterized by the rapid growth of disorganized blood vessels followed by slow spontaneous involution. The underlying molecular mechanisms that regulate hemangioma proliferation and involution still are not well elucidated. Read more
Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension
Journal of Clinical Investigation Insight
Excess macrophages and smooth muscle cells (SMCs) characterize many cardiovascular diseases, but crosstalk between these cell types is poorly defined. Pulmonary hypertension (PH) is a lethal disease in which lung arteriole SMCs proliferate and migrate, coating the normally unmuscularized distal arteriole. Read more
Open Call for Lipedema Research Proposals
Collaborative Research Award - Designed for team research that requires involvement of multiple institutions or muIti-disciplinary researchers. Applications that involve current LF grantees receive priority review. Up to $250,000 over two years.
Proof of Concept Award - Designed to support development of preliminary data for highly innovative hypotheses. Open to investigators of any career stage or background. Successful awards are eligible for streamlined award renewal. Up to $125,000 for one year
Mentored Award - Designed to support postdoctoral research experiences for candidates in non-independent mentored research training. Intended to support PhD (or equivalent research degrees) and clinicians engaged in mentored medical research. Up to $70,000 for two years
· Application Portal Opens: January 19, 2021
· LOI Submission: March 15, 2021; 11:59 PM EST
· Video Presentation with Lipedema Foundation staff and Full Application Invitations: April 2021
· Full Application Submission: June 26, 2021
· Award Status Update: August 31, 2021
· Earliest Project Start Date: October 1, 2021
Dates are subject to change at discretion of Lipedema Foundation. Registered applicants will be notified by email should these dates change.
Specific Areas of Interest
While the Foundation will consider all proposals, those that are oriented towards improving diagnosis of patients will be prioritized in the current cycle.
Applicants should consider the development of local surgeon-researcher teams that will facilitate access to fresh, well-characterized patient biological samples and appropriate controls.
Investigators requiring assistance with recruitment of patients or acquisition of biological samples should contact the Foundation at least 3 weeks prior to LOI submission to review feasibility of the request.
Proposals to create clinically relevant animal models should clearly justify the relationship of the proposed model to a genetic or biomechanical feature of Lipedema.
For questions regarding this RFP, please contact the Lipedema Foundation staff by email at email@example.com.
How to Apply
All applications must be submitted through the Lipedema Foundation research submission portal.
Please visit their website to find the link to the submission portal.
Industry News (from February 11 issue)
Lipedema gains ACC recognition as a distinct lymphatic disorder
Lipedema is a chronic condition that occurs almost exclusively in women and manifests as symmetrical buildup of painful fat and swelling in the limbs, sparing the hands and feet. The American College of Cardiology, in a recent revision of key conditions encountered by practicing vascular specialists, recognizes lipedema as a separate entity from the lymphatic disorders with which has normally been grouped. The report may not only influence specialty training but also spark trainees’ interest in research into improved lipedema diagnostics and treatment options. You can read more here about this recognition as well the Lipedema Foundation’s 2021 Request for Proposals in support of lipedema research.
National Academies report examines vaccine distribution strategies
While the COVID-19 pandemic continues to disrupt all aspects of life across the US and around the world, and scientists public policy experts alike labor to scale up vaccine manufacturing, production, allocation, and distribution. As the pandemic lingers, the new Biden administration, in league with state and local officials, must make difficult choices about how to balance public health priorities with other critical societal functions. In support of these efforts, the National Academies of Sciences, Engineering, and Medicine have deployed expertise in numerous disciplines to help the nation and the world respond and recover. A recent report from the National Academies outlines a four-phased framework to vaccine allocation that is guided by evidence on how to reduce deaths, prioritize vulnerable populations, and maximize societal benefit.
Toolkit available to enhance societal outreach effectiveness
Scientific publisher Springer Nature announces the launch of a new toolkit with which researchers can maximize the societal impact of their research. This resource was created in partnership with the Association of Universities in the Netherlands (VSNU), Dutch University Libraries and the National Library Consortium (UKB), supplemented by results of a survey of over 9,000 researchers representing different disciplines. The toolkit provides tips on selecting the channels best suited to reaching a target audience inside or outside academia, as well as approaches to assessing the impact of your outreach efforts. Available resources include interviews with senior researchers, sample impact plans for early career researchers, and insights on motivations, perceptions and actions to achieve maximum societal relevance in your field of research.
Frontiers in Cardiovascular Medicine
Special Research Topics
Putting Engineering Back In Vascular Tissue Engineering To Advance Basic Science and Clinical Applications
Topic Editors: Jessica Wagenseil (Washington University in St. Louis) and W. Lee Murfee (University of Florida).
This topic is sponsored by NAVBO
Vascular tissue engineering (VTE) can be characterized as the creation of replacement vessels. Over the past 30 years, approaches have incorporated different combinations of extracellular matrix scaffolds, cells and biological active chemical cues. Challenged by the goal to recapitulate the complexity of big or small vessels, the clinical use of in vitro tissue engineered vessel replacements is still limited. With research more often focusing on reductionist materials science or cell biology characterization of vessel-like constructs, an opportunity has emerged to re-apply engineering approaches to guide the next step in VTE.
Manuscript submission deadline has been extended; for more information, click here.
February Journal Club
NAVBO Session at ASIP
NAVBO 2021 Meritorious
New Focus Sessions
Lab of the Month
Spotlight on Trainees
Summer Training Program
Call for Proposals -
Call for Papers
And below . . .
VB2020 Guest Societies
Shop NAVBO Items
Subscribe to the VBPA
NAVBO Career Center
Calendar of Events
Registration and Abstract Submission Sites NOW OPEN!!
Help support our trainee scholarships
Any profits from the sale of these NAVBO items will help fund additional scholarships for students in the Advancing Young Voices Through Diversity and Inclusion Program. Thank you for your support!
Vascular Biology Publications Alert Now Available by Subscription
The NAVBO Vascular Biology Publications Alert will now be available to non-members for a $55 a year subscription. If you would like to receive this alert, but are not a member, please contact Danielle at firstname.lastname@example.org.
October 24-27, 2021