December 22, 2016 
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Lymphatic Forum
in Chicago, IL
June 8-10, 2017

Vasculata 2017
Chicago, IL 
July 24-27, 2017
(new dates!) 

Vascular Biology 2017
Monterey, CA  
October 15-19 
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President's Message
Dear NAVBO Members,
As we have reached the end of the year, I'd like to reach out to the NAVBO membership to briefly highlight events of the past year and let you know of exciting opportunities and initiatives in 2017.
Without a doubt, our big event during 2016 was hosting IVBM 2016. The meeting has been uniformly recognized as a success and this is in no small part due to all of your participation. I'm also happy to report that a team of NAVBO trainees and junior investigators are preparing a meeting report. We also launched meeting sessions that are developed by members, we enhanced participation of trainees on committees, and hosted the first "international" Vasculata.
This upcoming year, we are continuing to incorporate "member developed" sessions for Vascular Biology 2018. There are a few updates on these sessions. First, the deadline will be earlier this year - April 3, 2017 and, second, we have added the additional opportunity to propose an idea for the Vascular Therapeutics session. See the web site for more details.
I'm pleased to let you know that NAVBO is presenting three meetings this year:
  • Vascular Biology 2017 (October 15-19 at Asilomar) - features the Developmental Vascular Biology and Genetics Workshop, and pairing with this workshop for the first time, the Vascular Matrix Biology and Bioengineering Workshop. 

We have begun to search for the host of the 2018 Vasculata. If you are interested in organizing Vasculata at your institution, please see Proposals should be sent to the NAVBO office by January 20, 2017. The Education Committee reviews these submissions.


Finally, please continue to support NAVBO by renewing your membership! Please consider making a tax-deductible contribution to NAVBO - With your help we can continue to grow the field of vascular biology, support trainees, and provide exciting meetings.


On behalf of the NAVBO Council, Happy Holidays, we wish you a safe and productive 2017.


Jan Kitajewski, Ph.D.
NAVBO President, July '16-June '17

Most Read By You
Top Ten Reads from the NewsBEAT
The following links had the most click-throughs for the year:

 1. Lab of the Month:  Elisabetta Dejana, Ph.D.

 2.  Fine-tuning vascular fate during endothelial-mesenchymal transition. (Member Publication)

 3.  A Vision and Pathway for NIH - Recommendations for the New Administration

 4.  Lab of the Month: Stefania Nicoli, Ph.D.

 5.  Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo. (Member Publication)

 6.  Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. (Member Publication)

 7. Lab of the Month: Daniela Simona Ardelean, M.D., Ph.D.

 8.  Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression. (Member Publication)

 9.  Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior (Member Publication)

10. One Brave Idea Research Award

10. Lab of the Month: Matthew Spite, Ph.D.

And an honorable mention for the Lego Graduate! 

(please note, job and meeting announcements, and links to applications, registrations, renewals, etc. were not included) 
Throw-back Thursday
1988 NATO Conference
NAVBO member Ruth-Maria Korth of the Ludwig MaximiliansUniversity in Munich has kindly provided a group photo of the participants in a conference, "Vascular Endothelium: Receptors and Transduction Mechanisms," held in Porto Carras, Greece, June 18-29, 1988. The conference proceedings
, published in 1989 under the same title as Volume 308 of the NATO Science Series B, contains contributions from many leading investigators in vascular biology from that era, including at least two future Nobel laureates, as well as others who continue to lead our discipline and NAVBO to this day. Help us flesh out a caption by letting us know scientists you recognize!
(Click the photo for a larger image)
Lab of the Month
The Lab of Dr. Matthew Spite

This month we are highlighting the lab of Dr. Matthew Spite, who is an Assistant Professor at Harvard Medical School and in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital. Find out more about Dr. Spite's lab at

HHT Tissue Specimens Available
Anatomy Gifts Registry (AGR) has recovered multiple specimens from an HHT donor.  There is no cost to you at all, they just want to fulfill a donor family's wishes to impact HHT research.

AGR has samples (fixed and frozen) of liver, omentum, intestine, lung, suspected skin lesions, and pulmonary vessels.  All specimens appeared severely affected by the disease other than the pulmonary tissue. There were moderate to severe adhesions and some necrotic tissue noted during dissection in the abdominal cavity. The liver, omentum, intestine, and skin were in there preservative state at 0945. The lung and pulmonary tissue were preserved at 1230. All on 11/12/2016. The DOD was 11/10/16 and TOD 1348.

Please contact Corinne Bell at Anatomy Gifts Registry directly if you are interested in any of these HHT tissue specimens.
Corinne N. Bell, MS, RD, CTBS
Executive Director/ Chief Operations Officer
Anatomy Gifts Registry
Fax:   410-553-0502  
Cell/ Text:   443-623-0550
Member News
Welcome to our New Member:
Andreas Beyer, Medical College of Wisconsin
Spotlight on Trainees
Stronger support ahead for early-career scientists?
Science Magazine reports that the 21st Century Cures Act recently approved by the U.S. House of Representatives and Senate contains language encouraging the NIH develop strategies that foster earlier independence and improve long-term opportunities for junior biomedical researchers. According to Jodi Yellen, director of science policy at the Association of American Medical Colleges, the legislation reinforces the direction that NIH and the research community have been going in supporting the next generation of researchers. Specifically, the Act authorizes NIH to enhance ongoing efforts in the Office of the Director to develop and coordinate policies and programs related to new researchers and earlier independence.
 Recent Publications by NAVBO Members

Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process
Background - During adult life, blood vessel formation is thought to occur via angiogenic processes involving branching from existing vessels. An alternate proposal suggests that neo-vessels form from endothelial progenitors able to assemble the intimal layers.  Read more


Transition in the mechanism of flow-mediated dilation with aging and development of coronary artery disease
Basic Research in Cardiology
In microvessels of patients with coronary artery disease (CAD), flow-mediated dilation (FMD) is largely dependent upon the endothelium-derived hyperpolarizing factor H2O2. The goal of this study is to examine the influence of age and presence or absence of disease on the mechanism of FMD.  Read more


TSP1-CD47 Signaling is Upregulated in Clinical Pulmonary Hypertension and Contributes to Pulmonary Arterial Vasculopathy and Dysfunction
Cardiovascular Research
Aims: Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1-/- mice are protected from pulmonary hypertension (PH). The authors hypothesized the TSP1-CD47 axis is upregulated in human PH and promotes pulmonary arterial vasculopathy.  Read more


Gaso-Transmitters: Expanding the kinetic universe of cell signaling
American Journal of Physiology - Cell Physiology
This is an Editorial.  Read more


Nitric oxide: What's new to NO?
American Journal of Physiology - Cell Physiology
Nitric oxide (NO) is one of the critical components of the vasculature, regulating key signaling pathways in health. In macro-vessels NO functions to suppress cell inflammation as well as adhesion. In this way it inhibits thrombosis and promotes blood flow. It also functions to limit vessel constriction and vessel wall remodeling.  Read more


CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL
Antioxidants and Redox Signaling
AIMS: Macropinocytosis has been implicated in cardiovascular and other disorders yet the physiological factors that initiate fluid-phase internalization and the signaling mechanisms involved remain poorly identified. The present study was designed to examine whether matrix protein thrombospondin-1 (TSP1) stimulates macrophage macropinocytosis and, if so, to investigate the potential signaling mechanism involved.  Read more


Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field
Deveopmental Biology
Oxygenated blood from the heart is directed into the systemic circulation through the aortic arch arteries (AAAs). The AAAs arise by remodeling of three symmetrical pairs of pharyngeal arch arteries (PAAs), which connect the heart with the paired dorsal aortae at mid-gestation.  Read more


5,6-d-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation
Free Radical Biology and Medicine
Objective - Prominent among the endothelium-derived hyperpolarizing factors (EDHFs) are the Cytochrome P450 (CYP) epoxygenase-derived arachidonic acid metabolites-the epoxyeicosatrienoic acids (EETs), that are known as vasodilators in the microcirculation.  Read more

Job Postings
Job Title
Chicago, IL
Assistant/Associate/Full Professor - Physiology and Biophysics
University of Illinois at Chicago
Chicago, IL
Grenoble, France
Postdoctoral Researcher
University of Virginia
Charlottesville, VA
Calendar of Events
May 8-12, 2017
Keystone Symposia Conference - Angiogenesis and Vascular Disease
June 8-10, 2017
Lymphatic Forum 2017
Aug. 7-10, 2017
Vasculata 2017
Oct. 15-19, 2017
Vascular Biology 2017
June 4-7, 2018
20th International Vascular Biology Meeting
Look inside the IVBM Virtual Conference Bag
North American Vascular Biology Organization | |
18501 Kingshill Road
Germantown, MD 20874-2211