October 15-19, 2017
20th IVBM
Helsinki, Finland
June 3-7, 2018
Vasculata 2018
St. Louis, MO
July 23 - 26, 2018
 Vascular Biology
Newport, RI
October 14-18, 2018
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Congratulations to
Angiogenesis!
The new 2016 impact factor for
Angiogenesis has increased to
5.253*.
* 2016 Journal Citation Reports (Clarivate Analytics, 2017)
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Congratulations Babak Razani - 2017 Springer Awardee
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The NAVBO Meritorious Awards Committee and NAVBO Council are pleased to announce that Babak Razani, M.D., Ph.D., is the recipient of the 2017 Springer Junior Investigator Award, for which vascular biologists within five years of their first independent investigator position are eligible. Dr. Razani currently holds appointments as Assistant Professor of Medicine, Cardiovascular Division and Assistant Professor, Department of Pathology and Immunology at Washington University School of Medicine in St. Louis. His work focuses on the mechanisms of atherosclerosis and metabolic diseases, with particular focus on macrophages and the autophagy-lysosome system.
Please join us at Vascular Biology 2017 to hear Dr. Razani's Springer Award lecture, "Dissecting the impact of dietary protein on macrophage mTOR signaling and atherosclerosis," at 2:30pm on Wednesday, October 18, 2017 at the Asilomar Conference Grounds in Monterey. Congratulations, Dr. Razani!
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Special Events at Vascular Biology 2017
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Pre-Conference Meeting for Trainees
Sunday, October 15 - 2:00-6:00pm in the Fred Farr Forum
Organizers: Heena Kumra, McGill University and Mary Wallingford, University of Washington
Featured Speaker: George E. Davis, University of Missouri-Columbia
Additional registration fee required
Keynote Lecture
Sunday, October 15 at 7:30pm in Merrill Hall
Hematopoietic stem cell formation from hemogenic endothelium
Nancy A. Speck, Ph.D.
Professor of Cell and Developmental Biology
Perelman School of Medicine, University of Pennsylvania
Lunch and Learn
Monday, October 16 in the Woodland Room of the Crocker Dining Hall
Twelve senior investigators will host trainees at this special luncheon. Trainees can choose to participate onsite when picking up their badges.
Nano-Talks
Monday, October 16 at 4:30pm in the Chapel
Nano-talks are five minute presentations that feature only five slides. There will be five presentations that we hope will shed light on little understood areas or illuminate controversial areas.
Bioengineering Organ-Specific Vasculatures
Tuesday, October 17 - 2:00-4:00pm in Merrill Hall
Organizer: Juan Melero-Martin of Boston Children's Hospital
Chairs: Juan Melero Martin and Andrew Dudley, University of Virginia
Basics of fluid dynamics and shear stress definition in flow experiments
Sponsored by ibidi
Tuesday, October 17 - 4:15-4:45pm in the Chapel
More information below
Awards Presentations and Lectures
Wednesday, October 18 - 2:30-4:30pm in Merrill Hall
Features the Benditt, Folkman and Springer Award recipients
Vascular Therapeutics
Wednesday, October 18 - 7:00-9:00pm in Merrill Hall
Organizers/Chairs: Jan Kitajewski, University of Illinois at Chicago and Weilan Ye, Genentech
Engineering Vascular Morphogenesis
Thursday, October 19 - 2:30-4:30pm in the Chapel
Joint session of workshops
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How-To Session at Vascular Biology
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Basics of fluid dynamics and shear stress definition in flow experiments
An Exhibitor Showcase Sponsored by ibidi
Cell types, such as endothelial cells of blood and lymphatic vessels as well as epithelial cells of kidney and lung, are permanently experiencing the mechanical stimulus of the fluid flow under physiological conditions. This mechanical stimulus is known as shear stress. To approach these conditions
in vitro, the application of a defined flow (and thus shear stress) over the cell layer is necessary.
This session outlines the importance of flow conditioning by selected publications and gives you references of typical shear stress values in various tissues.
Learn how to establish a defined experimental setup for generating reproducible results.
Moreover, this session will provide a basic understanding of fluid dynamics in small channels and explains how to calculate the shear stress on the cells.
Further, example calculations are given for various ibidi Channel Slides, offering an easy and convenient solution for flow experiments.
This showcase will give you a profound understanding of fluid dynamics, which is crucial to establish flow experiments in your own lab.
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Mete Civelek, Ph.D.
University of Virginia
I started my laboratory at the Center for Public Health Genomics at the University of Virginia about two years ago. I made several good decisions as well as several mistakes during this time. While everyone's experiences will be different, I would like to share some of the lessons I learned with the hope that you will make wiser choices when you start your research group.
I immediately found a group of like-minded junior PIs who also started their labs around the same time as me at UVA. This group has been a great support both mentally and scientifically. In fact, four of us hold joint lab meetings together as we have overlapping interests. If you are just starting your lab, I highly recommend to you to be part of the New PI Slack, which is a community of about 400 junior faculty members primarily across the United States (
https://newpislack.wordpress.com/). This is a group of generous and thoughtful new PIs who share many things from examples of grant applications to advice for wet lab and computational tools, funding opportunities, how to deal with diversity-related issues, and even tips for work-life balance.
One of the mistakes I made was not to have a laser-like focus on a single project that will result in a publication as soon as possible. Since publications measure our productivity, it is important for a junior PI to prove that he/she can produce results as a result of all the investment an institution makes. My advice is to focus on a publication rather than grant applications in the first one or two years. If you are going to send in grant applications, it is better to apply to organizations that provide feedback so that you can improve your application by addressing the reviewers' comments and resubmit.
Hiring and managing people will prove to be challenging. You will not find a postdoctoral fellow or a graduate student who will be just like you. Many times, you will think "I could have done this in an hour instead of a day." I learned to be patient as I trained the lab members and allowed them to make mistakes. It is the only way the trainees are going to master the techniques. I also learned to look out for warning signs as it is important to correct the mistakes quickly so that they don't accumulate and become bigger problems in the future. I quickly learned that weekly one-on-one meetings where we go over even small details increased the productivity of the lab.
I am required to teach as part of my appointment. I started a new class in large-scale data analysis, and it took a considerable amount my time in the first year. Becoming a good teacher is an iterative process, and it takes time to be a good teacher. If you have teaching duties, set aside only one day of the week to prepare for the class. We all tend to have perfectionist qualities, but you do not want teaching to consume your precious time.
Finally, science is a collective effort. Your lab will be more productive if you can create a welcoming and fun environment in the lab where diverse ideas are openly discussed.
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The Lab of Dr. Mete Civelek
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Welcome to our Newest Members:
Federica Fontana, University of Potsdam
Teresa Monkkonen, UCSF
Bendix Slegtenhorst, Brigham & Women's Hospital, HMS
Andrew Sligar, The University of Texas at Austin
Melanie Torrie, Iowa State University
Chinmay Trivedi, UMass Medical School
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Recent Publications by NAVBO Members
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| Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair
JACC: Basic to Translational Science
The author's data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. Read more MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair after Myocardial Ischemia Reperfusion Injury
Circulation Research
Rationale: Clinical benefits of reperfusion after myocardial infarction (MI) are offset by maladaptive innate immune cell function and therapeutic interventions are lacking. Read more BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity
Arteriosclerosis, Thrombosis, and Vascular Biology
OBJECTIVE: The chromatin remodeling enzyme BRG1 (brahma-related gene 1) transcriptionally regulates target genes important for early blood vessel development and primitive hematopoiesis. Read more Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
The New England Journal of Medicine
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Read more Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial
The Lancet
Background: Inflammation in the tumour microenvironment mediated by interleukin 1β is hypothesised to have a major role in cancer invasiveness, progression, and metastases. Read more Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression
Oncogene
Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Read more |
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Job Postings
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Job Title
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Company
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Location
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Case Cardiovascular Institute
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Cleveland, OH
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Postdoctoral Research Fellow
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University of Illinois at Chicago
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Chicago, IL
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Yale University
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New Haven, CT
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Postdoctoral fellow
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Children's Hospital Los Angeles
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Los Angeles, CA
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UC Berkeley
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Berkeley, CA
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Postdoctoral Fellow
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Cincinnati Children's Hospital
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Cincinnati, OH
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University of Pittsburgh
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Pittsburgh, PA
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Assistant Member - Cardiovascular Biology
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OMRF
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Oklahoma City, OK
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Imperial College London
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London, England
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Assistant Postdoctoral Fellow Position
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Johns Hopkins University
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Baltimore, MD
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This month we are highlighting the lab of Dr. Mete Civelek, who is an Assistant Professor of Biomedical Engineering at the University of Virginia. Find out more about Dr. Civelek and his lab at 
