June 9, 2016 
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NAVBO members receive discounts on registration to IVBM 2016

Vasculata 2016
Uppsala University
University of Pennsylvania
August 15-17
Look inside the IVBM Virtual Conference Bag

Lymphatic Forum
in Chicago, IL
June 8-10, 2017

Vascular Biology 2017
Monterey, CA
October 15-19 
Corporate Partners
Corporate Members
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Gold Level

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Silver Level
Academic Supporters

Bronze Level
Academic Supporters

New Councilors
Cecilia M. Giachelli from the University of Washington has been elected to serve as our new President-Elect as of July 1.  Dr. Jan Kitajewski will take over as President and Dr. Joyce Bischoff will become our immediate Past President.

We also welcome new Councilors: Rosemary Akhurst, University of California, San Francisco, and Jason Fish, University of Toronto.  Their terms will run from July 1, 2016 through June 30, 2019.

A special thank you to those who were willing to run and serve the society - Dr. Mark Kahn (President-elect candidate) and Councilor Candidates: Drs. Daniel Greif, Guillermo Oliver, A. Wayne Orr, Anand Ramamurthi and Linda Shapiro.  We know that we can count on their continued support of our society. 
Vasculata 2016
Abstract Deadline is now July 1
Scholarship Application Deadline is June 27
Don't miss your opportunity to attend a meeting in Philadelphia, where the speakers are prominent European scientists!  Or you can travel to Sweden and see them in person.

In addition, Philadelphia will also host a Poster Session and is accepting abstracts.  Workshops will be held at both sites.

Scholarships are available
Whether you plan to attend Vasculata in Uppsala or Philadelphia, a limited number of scholarships are available to those with limited resources.  Apply for a scholarship at http://www.navbo.org/events/vasculata-2016/2016scholarships Deadline is June 27 .
To register, view the program, or submit an abstract go to: 
Meritorious Awards
Seeking Nominations for Meritorious Awards 
Nominate colleagues for the NAVBO Meritorious Awards - the Earl P. Benditt Award, recognizing an individual who has made an outstanding discovery or developed a concept that has been seminal to our understanding of vascular biology or pathology and the Judah Folkman Award in Vascular Biology, which recognizes an individual who has made a significant impact on the field through his/her original research accomplishments.  For more information about the awards and the nominating process, please visit our web site at http://www.navbo.org/awards/nominations-for-meritorious-awards
Nominations are due by July 8.  
Lessons Learned
My name is Sathish Srinivasan, and I am an Assistant Member at Oklahoma Medical Research Foundation (OMRF), located in the vibrant downtown area of Oklahoma City. I came to OMRF in February of 2013 after an enjoyable period of postdoctoral training in the lab of Dr. Guillermo Oliver at St. Jude Children's Research Hospital, Memphis. The last three years have been the most challenging of my entire life. Identifying the important questions, addressing those questions with innovative approaches, and being a motivating leader and spokesman for your team are very difficult tasks. Knowing that there is no guarantee for success makes each task all the more challenging. Here I will list a few things that I think are important for a startup lab. I hope that my experience will be helpful to others who are taking their first steps as independent investigators.
Getting the team together: As a new PI, it can be difficult to attract talented, motivated, and experienced researchers to join your team. However, setting the bar high is important both for the team and for the individual. I am very fortunate to have Xin Geng (staff scientist), Boksik Cha (post doc), and Lijuan Chen (research assistant) in my lab. They are my super heroes. Stephanie Yeager (research assistant) and Bing Liao (post doc) also made important contributions during their stay in the lab.
Plan to continue working in the lab: You will likely be the one with the most experience in your field when starting the lab. Be ready to continue working in the lab and training others. The time invested will pay off. Riaj Mahamud (graduate student), who joined my lab with little experience but with a strong motivation, is now a well-trained, important member of my lab.
Don't hesitate to invest in your startup: Proper reagents and tools are a must to run your lab, so don't be stingy in making that mouse model or buying that microscope. But do get a quote and make sure you will get good service.
Be generous: You got hired because other PIs in the institution thought that they could collaborate with you; be willing to share your expertise and resources to help others both within and outside of the institution. The favor will be returned to you many times over.
Choose your collaborators carefully: I am lucky to have many thoughtful collaborators. However, collaborator-on-collaborator conflict is not uncommon and could be career-ending. Make sure you are truly independent in collaborative projects. Also, verify the sincerity of a collaboration request. You don't want your precious time and energy to be wasted on projects that the collaborators are not serious about.
Focus: When I started the lab, I wanted to simultaneously work on 10 different projects and write five R01 applications. It was an exercise in futility. Focus on the most important questions that you can address with your expertise and resources and for which you are recognized. Try to obtain small grant funding that will keep your lab moving forward. Bigger grants, such as an NIH R01 grant, need plenty of time and work before applying. The time you spend on writing those big grants can be better spent in generating the preliminary data and publications that are absolutely important in getting those larger grants funded.
Be cautious...: In this highly competitive research environment, it is important to find a balance between camaraderie and caution. Avoid presenting unpublished data until you get some traction.
...but don't get cynical: Many papers and grants do get favorably reviewed due to the political connections of the PIs. Yours may seem to be unfairly reviewed. You will be angry and discouraged, but acknowledge the reality and your emotions and move on. Grow a thick skin, keep improving, and believe that good science will be appreciated and acknowledged sooner or later. I am fortunate to have known plenty of researchers who are genuinely curious about nature, passionate about research and kind-hearted to support others.
Improve your writing skills: It is important to have good science. It is even more important to communicate your work well. My first two R01 applications were beaten down, and rightfully so. Now my grantsmanship is a work in progress. Do everything possible to make your grants and papers easy to read and understand. Your peers deserve that respect.
Try to relax: If we are lucky, we are expected to be creative and productive for 30-40 years. It is a daunting task. When I confided my fear to Mike Davis (University of Missouri, Columbia), he gave me the best career advice that I ever got. If you are worried about everything, you are not going to do anything. Andrew McMahon likens the scientific career to running a marathon. You have to plan for the next 3-5 miles (years) and not focus on the finish line. So find your circle of supporters, spend quality time with your family, develop a hobby, read good literature and give a good fight. It ain't over 'til it's over.

See "Lessons Learned" pieces on our web site - http://www.navbo.org/resources/lessons-learned 
Lab of the Month
The Lab of Dr. Sathish Srinivasan
This month we are highlighting the lab of Dr. Srinivasa of the Oklahoma Medical Research Foundation of the University of Oklahoma. Find out more about Dr. Srinivasan's lab at http://www.navbo.org/membership/members-labs/521-lab062016.
View all featured laboratories at navbo.org/membership/members-labs.
Member News
Welcome our newest members:
Meenal Datta, Massachusetts General Hospital
Emilia Korhonen, University of Helsinki
Lee Meier, University of Minnesota
Cristina Sastre, Massachusetts General Hospital
Wei Zhang, Albany Medical College

If you have news to share with your colleagues, send it to membership@navbo.org.
Product Showcase
Submit your next manuscript to Thrombosis and Haemostasis - International Journal for Vascular Biology and Medicine!

The current average turnaround time from submission to first decision is only 23 days and the Impact Factor 2014 is 4.984.
The following Manuscript categories are accepted for review by the Editorial Board:

Original Articles: Coagulation and Fibrinolysis; Cellular Haemostasis and Platelets; Blood Cells, Inflammation and Infection; Endothelium and Angiogenesis; Cellular Signalling and Proteolysis; New Technologies, Diagnostic Tools and Drugs; Stroke, Systemic or Venous Thromboembolism; and Atherosclerosis and Ischaemic Disease 
Letters to the Editor (incl. Case Reports) 
T&H Images 
Trial Design Papers 
Review Articles (contact Editorial Office before Submission)
Here you can find the instructions and forms for your online submission: http://th.schattauer.de/en/authors/manuscript-submission.html

Spotlight on Trainees
Balancing the time demands of graduate study against the need to attend to friends and family is challenging under the least complicated of circumstances. Add to that the unparalleled mix of joy and stress that accompanies learning that one's family is about to grow. "D uring the spring of 2015," writes McKenzie Wood in The Chronicle of Higher Education, "I had the momentous experience of being pregnant through three of the most transitional periods of my life - the end of graduate school, the job market, and the beginning of my new faculty position. Although being on the job market while pregnant was no cakewalk, and starting my first semester as a faculty member the week before I was due was not exactly convenient, the most trying time of my whole pregnancy was the six months I was completing my dissertation in grad school." Read more

 Recent Publications by NAVBO Members

Human Arterial Ring Angiogenesis Assay
Angiogenesis Protocols
In this chapter the authors describe a model of human angiogenesis where artery explants from umbilical cords are embedded in gel matrices and subsequently produce capillary-like structures. The human arterial ring (hAR) assay is an innovative system that enables three-dimensional (3D) and live studies of human angiogenesis.  Read more

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications
Circulation Research
Impaired angiogenesis has been implicated in adipose tissue dysfunction and the development of obesity and associated metabolic disorders. Here, the authors report the unexpected finding that vascular endothelial growth factor B (VEGFB) gene transduction into mice inhibits obesity-associated inflammation and improves metabolic health without changes in body weight or ectopic lipid deposition.  Read more

Lymphatic System in Cardiovascular Medicine
Cell Metabolism
The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively regulates tissue fluid homeostasis, absorption of gastrointestinal lipids, and trafficking of antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation.  Read more

Endothelial-to-Mesenchymal Transition: An Evolving Paradigm and a Promising Therapeutic Target in PAH
Pulmonary arterial hypertension (PAH) is a complex and progressive disorder, which almost always leads to right heart failure and death1. PAH is invariably associated with a spectrum of structural changes in the pulmonary arteries: increased adventitial and medial thickness, eccentric and concentric intimal thickening, the obliteration and recanalization of arteries and the appearance of dilation lesions.  Read more

Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment
Current Hypertension Reports
Stiffening of the pulmonary arterial bed with the subsequent increased load on the right ventricle is a paramount feature of pulmonary hypertension (PH). The pathophysiology of vascular stiffening is a complex and self-reinforcing function of extracellular matrix remodeling, driven by recruitment of circulating inflammatory cells and their interactions with resident vascular cells, and mechanotransduction of altered hemodynamic forces throughout the ventricular-vascular axis.  Read more

Endothelial Lipid Phosphate Phosphatase-3 Deficiency that Disrupts the Endothelial Barrier Function is a Modifier of Cardiovascular Development
Cardiovascular Research
Aim: Lipid phosphate phosphatase (LPP)3 is expressed at high levels in endothelial cells (ECs). Although LPP3 is known to hydrolyze the phosphate group from lysolipids such as Spingosine-1-phosphate (S1P) and its structural homologs, however, the function of Lpp3 in ECs is not completely understood. In this study, the authors investigated how tyrosine-protein kinase receptor (TEK or Tie2) promoter-dependent deletion of Lpp3 alters EC activities.  Read more

Job Postings
Job Title
Yale University School of Medicine
New Haven, CT
Postdoctoral Positions
University of Massachusetts Medical School
Worcester, MA
University of Illinois at Chicago
Chicago, IL
Postdoctoral fellowship in vascular biology
Brigham and Women's Hospital
Boston, MA
LSU Health Sciences Center
Shreveport, LA
Calendar of Events
July 17-22 Endothelial Cell Phenotypes in Health and Disease
Aug. 15-18 Vasculata 2016
Sept. 7-10 ISACB - 15th Biennial Meeting
Sept. 26-28 Perspectives in Vascular Biology
Oct. 30 - Nov. 3 19th International Vascular Biology Meeting
Nov. 13-16 American Society for Matrix Biology Biennial Meeting
Industry News
Links between heart disease and intestinal microbiota
Current Heart Failure Reports
From the abstract: Changes in gut microbiota can initiate systemic inflammation, recognized as a contributor to the pathophysiology of heart failure. Investigators at the Cleveland Clinic report that the metabolite trimethylamine N-oxide (TMAO), derived by gut microbiota from dietary nutrients, is a significant promoter of diseases of the heart and kidney. Much remains to be learned regarding mechanisms by which gut microbiota may influence the development of heart failure.

MicroRNA-93 in control of peripheral blood mononuclear cell VEGF-A expression in Kawasaki disease
Pediatrics Research
From the abstract: Kawasaki Disease, a systemic vasculitis syndrome, primarily affects medium-sized arteries, including the coronaries. Investigators at Toyama, Japan and University of Utah report, in a study of 23 KD patients and 12 controls, strikingly high levels of miR-182 and miR-296-5p during the acute febrile phase, and of miR-93, miR-145-5p, miR-145-3p, and miR-150-3p in the defervescence stage. The expression of VEGF-A mRNA by circulating mononuclear cells, previously reported to be controlled by miR-93, was negatively correlated with the expression of this microRNA. miR-93 may thus contribute to the pathogenesis of arteritis in acute KD.

Migraine and cardiovascular disease risk in women
British Medical Journal

From the abstract: An international team of investigators has examined the long-term association between migraine headaches and cardiovascular disease in a subset of female participants in the Nurses' Health Study II. Migraine occurrence was associated, after adjustment for potential confounding factors, with an increased risk for major cardiovascular disease, myocardial infarction, angina/coronary revascularization procedures, and cardiovascular disease mortality. Results of this large, prospective cohort study in women with more than 20 years of follow-up indicate a consistent link between migraine and cardiovascular disease events.
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