April 14, 2016 
Home           Membership           Events           Awards           Resources
In This Issue

NAVBO members receive discounts on registration to IVBM

Travel Awards available for NAVBO members

Vasculata 2016
Uppsala University
University of Pennsylvania
August 15-18
Look inside the IVBM Virtual Conference Bag

Lymphatic Conference
in Chicago, IL
June 8-11, 2017

Vascular Biology 2017
Monterey, CA
October 15-19 
Corporate Partners
Corporate Members
Affiliated Journals
IVBM Supporters
Diamond Level
Welcome Reception Host

Event Partner

Silver Level
Academic Supporters

Bronze Level
Academic Supporter

New Job Board - NAVBO Career Center
Introducing our New Career Center
Our Career Center definitely needed a face lift!  Well, we've done that and more. This new Career Center (or Job Board) is now hosted by Web Scribble.  Members of the Council and Membership Committee reviewed this service and felt that it would serve our members better.  At this time we have the basics, but look for more customization in the future.

The biggest benefit to members is lower prices on the enhancements.  AND, one of the enhancements is the ability to have your job posting included within the Indeed web site.

All current members are included as Employers (regular members) or Job Seekers (trainee members).  Your log in is your email address.  When you access the site for the first time, you will need to reset your password.  You will have to enter your NAVBO Member Id to obtain the member discounts.

Please take a look at the new Career Center - www.navbo.org/resources/jobs
Organize a Session for Vascular Biology 2017
The deadline to submit your proposal for a session at Vascular Biology 2017 is May 1, 2016.  Go to http://www.navbo.org/events/vb2017 for more details.
Lessons Learned
The NAVBO Education Committee has asked some junior faculty to share their experiences during the transition from trainee to first independent post.  We hope that their accounts of challenges confronted, dilemmas dissected, and lessons learned will help smooth your career path.  If you would like to share your own experiences, please send us reflections on your transition to Assistant Professor or whatever form of solo flight you undertook.  What helped you, what held you back, what was the "if only I had known" secret you can share.  Send your piece to editor@navbo.org.

The View from the Other Side of the Desk 
My name is Stefania Nicoli, and I have been an Assistant Professor at the Yale Cardiovascular Research Center since 2012. This four-year journey in the academic world, more than any previous experience, has made me understand the importance of mentoring models for junior faculty.
Reaching the other side of the desk is what everybody dreams of during their training positions. However, during this time you are not only learning to become a boss but also a mentor. You are now in charge of efficiently communicating, motivating your employees, solving team conflicts, understanding and working with their career and life priorities, their weaknesses and reactions to stress and rejection, and ultimately, their success. Indeed, it appears that this part of the work is energy consuming and sometimes no matter what you might say or do you are wrong and for many of us this feeling, together with the continuous stress of reaching scientific excellence, is overwhelming.
Becoming a boss might be a natural process for a new faculty member, as we ourselves reached this academic status thanks to determination, self-assurance and hard work, traits typical of a leader. However, becoming a mentor is not necessarily included in our natural predispositions. Seeking direction, I asked several senior colleagues about their experiences regarding how they became mentors. Interestingly, there are various theories, all very personal, that I would like to classify into two distinct points of view: the Darwinian or Lamarckian theory of the junior faculty evolution. Essentially some faculty members believe in "natural selection" of the strongest phenotype. Others believe in the progressive learning process of more complex skills that allow successful "adaptation and survival" in any environment.
Of course, this sounds like a scientific joke, but there is some truth in both theories. Indeed, in our competitive and difficult economic climate, scientists have limited time to learn naturally from their mistakes. Therefore, learning quickly is the key to successfully "survive" and "drive." I found it crucial having someone to teach us mentoring strategies as rapidly as possible, to avoid energy dispersion while also gaining efficiency. For example, attending periodic psychology workshops or leadership courses is essential in acquiring these tools. High profile corporations invest time and considerable resources understanding strategies to make employees more efficient. Obviously, academia might not have the same capacity, but an investment toward junior faculty mentoring programs is, in the long run, important for the success of the entire institution.

For information about Dr. Nicoli's lab, visit our Lab of the Month (below).
Lab of the Month
The Lab of Dr. Stefania Nicoli
This month we are highlighting the lab of Dr. Stefania Nicoli of the Cardiovascular Research Institute of Yale University. Find out more about Dr. Nicoli's lab at http://www.navbo.org/membership/members-labs/496-lab042016.
View all featured laboratories at navbo.org/membership/members-labs.
Member News
Welcome our newest members
Eugene Butcher, Stanford University
Ana Kasirer-Friede, University of California, San Diego

If you have news to share with your colleagues, send it to membership@navbo.org.
Product Showcase
Hypertension in Pregnancy
publishes data pertaining to human and animal hypertension during gestation. Topics covered in the journal include physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy. Learn more about the journal and enjoy complimentary access to editor's choice articles from the most recently published issue on the journal's website: www.tandfonline.com/IHIP.  
Spotlight on Trainees
Gordon Conference Travel Awards
NAVBO has set aside funds to provide up to two $500 travel awards for trainees to attend this year's Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease, to be held in Girona, Spain on July 17-22, 2016. Graduate and medical students and postdoctoral trainees who are NAVBO members and submit an abstract for the meeting are eligible to apply. Your PI must also be a member of NAVBO.  Visit the our web site for more information. Applications are due to NAVBO by June 1, 2016.
 Recent Publications by NAVBO Members

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo
Nature Cell Biology
How vascular tubes build, maintain and adapt continuously perfused lumens to meet local metabolic needs remains poorly understood. Recent studies showed that blood flow itself plays a critical role in the remodelling of vascular networks, and suggested it is also required for the lumenization of new vascular connections.  Read more 

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling
Endothelial cells respond to molecular and physical forces in development and vascular homeostasis. Deregulation of endothelial responses to flow-induced shear is believed to contribute to many aspects of cardiovascular diseases including atherosclerosis.  Read more 

Decreased blood vessel leakage can improve cancer therapy and reduce tumour spread
Nature Communications
Cancer therapy is often hampered by the accumulation of fluids in and around the tumour, which is caused by leakage from the blood vessels in the tumour. Researchers at Uppsala University now show how leakage from blood vessels is regulated.  Read more 

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance
Science Advances
Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulation in adipose tissue via Toll-like receptor 9 (TLR9), originally known as a sensor of exogenous DNA fragments.  Read more 

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
Nature Methods
Here we describe the development of a human lung 'small airway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying microvascular endothelium that experiences fluid flow, which allows for analysis of organ-level lung pathophysiology in vitro.  Read more 

Purified and recombinant hemopexin: protease activity and effect on neutrophil chemotaxis
Molecular Medicine
OBJECTIVE: Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity and inhibition of chemotaxis.  Read more 

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
PLoS One
Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human blood-brain barrier (BBB) within a microfluidic chip by creating a cylindrical collagen gel containing a central hollow lumen inside a microchannel, culturing primary human brain microvascular endothelial cells on the gel's inner surface, and flowing medium through the lumen.  Read more 

Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice
Arteriosclerosis, Thrombosis and Vascular Biology
OBJECTIVE: Angiotensin II (AngII) infusion profoundly increases activity of calpains, calcium-dependent neutral cysteine proteases, in mice. Pharmacological inhibition of calpains attenuates AngII-induced aortic medial macrophage accumulation, atherosclerosis, and abdominal aortic aneurysm in mice.  Read more 

A role for the long non-coding RNA SENCR in commitment and function of endothelial cells
Molecular Therapy
Despite the increasing importance of long non-coding RNA in physiology and disease, their role in endothelial biology remains poorly understood. Growing evidence has highlighted them to be essential regulators of human embryonic stem cell differentiation.  Read more 

Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair Following Inflammatory Vascular Injury
Background - The integrity of endothelial monolayer is a sine qua non for vascular homeostasis and maintenance of tissue fluid balance. However, little is known about the signaling pathways regulating regeneration of the endothelial barrier following inflammatory vascular injury.  Read more 

Job Postings
Job Title
University of Rochester
Rochester, NY
Postdoctoral Fellows
Duke University
Durham, NC
Boston Children's Hospital - Harvard Medical School
Boston, MA
Research Associate
University of Toronto
Toronto, ON
University of Florida
Gainesville, FL
Postdoctoral Research Fellowship
Case Western Reserve University
Cleveland, OH
Calendar of Events
Date Event
April 2-6
May 2-3
11th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease
May 25-28
ISTH 62nd Annual Scientific and Standardization Committee Meeting
July 17-22 Endothelial Cell Phenotypes in Health and Disease
Sept. 7-10 ISACB - 15th Biennial Meeting
Nov. 13-16
Industry News
Reverse Engineering Human Pathophysiology with Organs-on-Chips
While studies of cultured cells have led to new insights into biological control, greater understanding of human pathophysiology requires the development of experimental systems that permit analysis of intercellular communications and tissue-tissue interactions in a more relevant organ context.   Read more 

Morphogenesis of 3D vascular networks is regulated by tensile forces
Understanding the forces controlling vascular network properties and morphology can enhance in vitro tissue vascularization and graft integration prospects. This work assessed the effect of uniaxial cell-induced and externally applied tensile forces on the morphology of vascular networks formed within fibroblast and endothelial cell-embedded 3D polymeric constructs.   Read more 

Cardiovascular events in systemic lupus erythematosus
An internation clinical consortium focused on lupus and associated morbidities has  reported that lupus patients experience an early elevated risk of cardiovascular disease, and that such disease may be manifest prior to a diagnosis of lupus.  These findings are suggestive of a link between chronic autoimmune-mediated inflammation and the development of atherosclerosis. 

Extended treatment with anti-VEGF agents in  diabetic
macular edema
In a study of nearly 700 patients, investigators at Genentech, in conjunction with clinical specialists in retinal disease, report that DME patients with limited initial anatomic response to ranibizumab show delayed but equivalent therapeutic benefit with extended intravitreal treatment (24 months).  Thus, certain patients may be slow to respond anatomically, but still can experience vision gains and retinopathy improvement. The findings reaffirm the discordance between retinal thickness and visual acuity.
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211