April 30, 2020
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In This Issue
William R. Huckle, Editor
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Special Session - COVID-19
Current Understanding of COVID-19 Pathology
May 8 at 1:00EDT

Clinical Trials for COVID-19
Vinicio de Jesus Perez,
Stanford University
What are we Learning from COVID-19 Autopsies
William A. Muller,
Northwestern University
COVID-19 and NIH-funded research  
Zorina Galis, NHLBI/NIH
Unfortunately, we decided to postpone Vasculata until summer 2021.  See our statement online. 

The organizers of the IVBM2020 in Seoul continue to plan the meeting.  See their web site.

Boston, MA
Postponed until Summer 2021

September 9-12, 2020
Abstracts due May 31, 2020
Travel Awards available

Vascular Biology 2020
Newport, RI
October 25-29, 2020

June 18-22, 2021 - Visit Website
Corporate Partners

Corporate Members

VB2020 Supporters


VB2020 Exhibitors

Affiliated Journals

Subscription for VBPA
Vascular Biology Publications Alert Now Available by Subscription
The NAVBO Vascular Biology Publications Alert will now be available to non-members for a $55 a year subscription.  If you would like to receive this alert, but are not a member, please contact Danielle at membership@navbo.org.
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Partner Network Advantage on the NAVBO Job Board
Why post your job on NAVBO's career center rather than going directly to the larger job networks?
Pricing on the mass job boards can vary, but to get a job noticed you typically have to sponsor it for $5 - $10 per day, which can add up quickly especially since you also pay for each click the job gets. When you add it all together, you could be spending up to $45 per day on your job posting. But, when posting a job on NAVBO's career center, you simply pay a flat fee! The Premium package includes our Exclusive Extended Partner Network - which means the jobs are broadcast to sites like ZipRecruiter and Jobs2Careers and more for a flat fee.
With special member pricing, you can post a job for as low as $300 with this Partner Network. You never pay for each click, just the flat fee on the NAVBO career center. In addition, the Premium package includes a 60-day job posting making it a great value. The Premium packages also offer features like having your company's logo featured on the career center homepage, having your job appear first in search results, and more.
Post your open position now at www.navbo.org/jobs!
NAVBO Privacy Policy
Your data privacy and security are important to NAVBO. To that end, we have updated our privacy policy to reflect recent privacy and security regulation implementations and changes. Please review our policy as time permits so you have a complete understanding of the data we have, why we have it, and how we use it.
Part of the updates relate directly to the European Union's new General Data Protection Regulation (GDPR) that went into place May 25.   The GDPR seeks to improve the transparency of data usage and give end users more control over their own data. We believe these changes are important and will be compliant with the GDPR regulations.
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Today's Mini-Symposium
Today's session:

April 30, at 1:00pmET

The session will feature the following presentations:
Non-proteolytic ubiquitination in oxLDL/disturbed flow-induced endothelial activation
Dongdong Wang, Louisiana State University, Health Sciences Center-Shreveport
Staphylococcus aureus toxin alpha hemolysin increases endothelial cell proliferation and disrupts pericyte coverage of arteries in a murine retinal model
Sonia Hernandez, University of Chicago
Flow-sensitive PLPP3 regulates YAP/TAZ mechano-responses in vascular endothelium
Jiayu Zhu, University of Chicago

The session will be moderated by Bill Hughes, Medical College of Wisconsin

May 12 at 1:00pmET

The session will feature the following presentations:
Single-cell Transcriptomes Identify Abnormal Endothelial Subpopulations in Pulmonary Arterial Hypertension
Zhiyu Dai, University of Arizona)
A New Approach in Cardiac Oncology: Lessons Learned from Coronary Artery Disease
Andreas Beyer, Medical College of Wisconsin
Premature induction of Lysyl Oxidase drives early arterial stiffening in Hutchinson-Gilford Progeria Syndrome (HGPS)
Ryan von Kleeck, University of Pennsylvania

The session will be moderated by William Hughes, Medical College of Wisconsin and Redouane Aherrahrou, University of Virginia

Please note:  the mini-symposia will NOT be recorded.

Want to present your own work in a mini-symposium? Submit your application here. Must be a current NAVBO member to submit.

For more offerings - see https://www.navbo.org/events/online
Vascular Malformation - Live Discussion
Join us Monday, May 4 at 1:00pmET

Live Discussion on Vascular Malformation with Joyce Bischoff, Mark Kahn and Stryder Meadows

We'll revisit their webinars and host a live question and answer session.  Review the webinars prior to the presentation.  Register for the live discussion here: https://attendee.gotowebinar.com/register/1024154805455271435
Links to the recordings are below.

Capillary malformations: From somatic GNAQ mutation to disrupted endothelial function
Joyce Bischoff, Boston Children's Hospital, Harvard Medical School

The Gut-Brain Axis in Cerebral Cavernous Malformation
Mark Kahn, University of Pennsylvania School of Medicine
(due to a technical issue, skip the first 4 minutes)

Angiopoietin-2 inhibition rescues arteriovenous malformation in a Smad4 HHT mouse model
Stryder Meadows, Tulane University
Find All Things NAVBO
Introducing the NAVBO Guided Tour

Everything NAVBO offers in a simple visual menu - click on the image to check out the full board.
Next Journal Club
"Join the Club" on May 21 at 1:00pm ET
We'll be discussing, " Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues "
Michelle B.Chen, Andrew C. Yang, Hanadie Yousef, Davis Lee, Winnie Chen, Nicholas Schaum, Benoit Lehallier, Stephen R.Quake, Tony Wyss-Coray 

Access information will be sent to current NAVBO members via email or join through the Journal Club Forum at https://www.navbo.org/forum/05-20journal-club (login required).
Leadership Opportunity - NAVBO Council
Seeking NAVBO Councilors
If you are a regular NAVBO member in good standing (dues paid through December 31, 2020 or later) you are eligible to run for Council.  If you would like to take an active leadership role in this society and help guide our mission, please take the time to apply for a position on the NAVBO Council.  Six applicants will be chosen for the ballot.  Deadline to submit is May 10, 2020.  See http://www.navbo.org/membership/call-for-council-nominations .  You will need to log in.
Upcoming Webinars
Upcoming Webinars  

In May, we welcome Martin Schwartz of Yale School of Medicine.  His presentation is
Matrix remodeling and integrin signaling in endothelial function and dysfunction.  Please plan to attend Dr. Schwartz' webinar on May 14 at 1:00pmET. For more information and to register for this webinar, please go to our web site. 
And in June, we welcome Mary Wallingford of the Mother Infant Research Institute at Tufts Medical Center.  Dr. Wallingford's webinar, Essential Yet Transient: An Introduction to the Placental Circulatory System is scheduled for June 11.  
Join us!!  NAVBO Webinars are free to current NAVBO Members. Non-members can attend for $25 per webinar.   

And don't forget you can watch recorded webinars as well - go to  
Leaders' Lessons (from the April 2 issue)
Welcome to the inaugural edition of Leaders' Lessons, the newest NAVBO NewsBEAT feature!
Regular readers of NewsBEAT will be familiar with the popular bimonthly Lessons Learned feature in which junior faculty members share their experiences and advice to help trainees and new faculty navigate this important and sometimes difficult period of their career. Building on the success of Lessons Learned, Leaders' Lessons is a bimonthly forum in which senior members of the NAVBO community will share their wisdom and advice on how to succeed throughout one's career. Each article will feature curated responses from several experienced scientists on a single topic, offering a rich diversity of advice and opinions that we all can learn from.

This month's question is "How can faculty maintain trajectory throughout their career?" Several NAVBO Council Officers generously shared their advice for this first edition - many thanks to all of them for their insights.

In the coming months, we want to address YOUR questions - please send your suggestions to anita@navbo.org.

And of course, we also need our senior members to contribute and will be reaching out to many of you in the coming weeks to ask for your lessons as leaders. As Linda advises below, "once you are established, it's time to give back"!

Leaders' Lessons: How can faculty maintain trajectory throughout their career?

Masanori Aikawa, Brigham & Women's Hospital, Harvard Medical School
I have always tried to implement new technologies in my manuscripts or grant applications.
I have also focused on proposing new concepts rather than follow in others' footsteps. 
I have tried my best to maintain mutual trust between leadership members of my department or division.  If you support them, they may want to support your career development too.
I suggest to my trainees to have courage to innovate, which energizes the entire team so that you as a PI can fly high with them.

Ondine Cleaver, UT Southwestern Medical Center
How to maintain your career trajectory in science throughout your career? My answer is do what you love. Stick to the science that excites you, and put one foot in front of the other to get the answers you seek. It's not easy, be clear on that right upfront. But with a sense of humor, resilience, persistence, and creating peer groups for cross-critiques, venting and support, it can be done. Demand critical feedback, and thicken your skin so you can make use of it. Value and foster a love of discovery in your labs, simultaneously challenging them and appreciating their efforts. Write those papers and grants, and expect rejections. But keep submitting. Remember it's a marathon, not a race. So learn to enjoy running, and maybe the view along the way.

For responses from Bill Muller, Northwestern University, Kristy Red-Horse, Stanford University,Linda Shapiro, University of Connecticut Health Center and Cindy St. Hillaire, University of Pittsburgh visit our web site:
Member News
Welcome to our New Members:
Nigeste Carter,  Eastern Virginia Medical School
Adam Keen, University of Oxford
Allison MathiesenEastern Virginia Medical School
Vedanta Mehta, University of Oxford
KarLai Pang, University of Oxford
Luke Payne, University of Oxford
Helena  Rodriguez Caro, University of Oxford
Lisa Simpson, University of Oxford
Mauro Siragusa, Goethe University
Aravin Sukumar,  University of Toronto
Kenneth Wolters, German Cancer Research Center
If you have news to share with your colleagues, send it to membership@navbo.org
Lab of the Month
The Lab of Dr. Angela Glading
This month we are highlighting the lab of Dr. Angela Glading, who is an Associate Professor at the University of Rochester. Find out more about Dr. Glading's lab at https://www.navbo.org/membership/members-labs/913-lab042020.
Spotlight on Trainees
The Science & SciLifeLab Prize for Young Scientists is an annual prize awarded to early-career scientists. The prize is presented in four categories:
* Cell and Molecular Biology
* Genomics, Proteomics and Systems Biology Approaches
* Ecology and Environment
* Molecular Medicine
Applicants are to submit a 1000-word essay that is judged by an independent editorial team organized by the journal Science. Essays are judged on the quality of research and the applicants' ability to articulate how their work would contribute to the scientific field.
As a winner, you will have your essay published by Science, win up to USD 30,000 and be invited to Sweden where you will receive your award, present your research and meet with leading scientists in your field.
Eligible entrants must have been awarded their doctoral degree in 2018 or 2019. The winners from each category will compete for the Grand Prize. The Grand Prize winner will receive 30,000 USD and be published in Science magazine. The three remaining category winners will receive 10,000 USD each and be published in Science online.
Read more: scienceprize.scilifelab.se

Questions/Inquiries: SciLifeLabPrize@aaas.org 
IVBM 2020
Abstract Submissions Deadline is  May 31
The IVBM2020 deadline for submission of abstracts for both poster presentation and short talks is May 31. 
The IVBM 2020 Organizers are closely monitoring the COVID-19 outbreak.  They continue to plan for the IVBM to take place in September. For more information, see the meeting web site, https://ivbm2020.org or contact the IVBM Secretariat at office@ivbm2020.org.

NAVBO will Present Up to 8 Travel Awards to the 2020 IVBM   
The submission deadline for the award application is now May 31.

If you are a NAVBO Trainee Member and plan to attend IVBM2020 in Seoul (September 9-12), please submit an application for a travel award (you must be submitting an abstract and be the presenting author). 
More information can be found on our web site at:

Information about travel awards from other societies can be found here
Recent Publicatons by NAVBO Members
Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy 
As the general population ages, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging of eye disease mouse models. Read more
BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance 
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant vascular disorder characterized by development of high-flow arteriovenous malformations (AVMs) that can lead to stroke or high-output heart failure. HHT2 is caused by heterozygous mutations in ACVRL1, which encodes an endothelial cell bone morphogenetic protein (BMP) receptor, ALK1. Read more
The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis 
The Dll4-Notch-signaling pathway regulates capillary sprouting via the specification of endothelial tip cells. While VEGF is a potent inducer of Dll4 expression, the intracellular mediators that stimulate its expression remain poorly defined. Read more
Endothelial-epithelial communication in polycystic kidney disease: Role of vascular endothelial growth factor signalling 
Cellular Signalling
Whereas targeting the cyst epithelium and its molecular machinery has been the prevailing clinical strategy for polycystic kidney disease, the endothelium, including blood vasculature and lymphatics, is emerging as an important player in this disorder. Read more
Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases 
Journal of the American Society of Nephrology
The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and cells from the renal interstitium. Through modulating immune responses and via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. Read more
Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5' Untranslated Region 
Journal of the American Heart Association
Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis. Read more
PERK Inhibition Mitigates Restenosis and Thrombosis: A Potential Low-Thrombogenic Antirestenotic Paradigm 
JACC- Basic to Translational Science
Background- Drug-eluting stents (DES) represent the main-stream management of restenosis following treatments of occlusive cardiovascular diseases. However, DES cannot eliminate instent restenosis yet exacerbate thrombogenic risks. Read more
Call for Abstracts

Dear Friends and Colleagues,
Juan Melero-Martin and Kai Wang are organizing a Methods Collection titled "  Current Methods in Vascular Network Bioengineering: from Stem Cells to Organoid Systems and Tissue Engineering " for the Journal of Visualized Experiments (JoVE).
The purpose of the collection is to offer a comprehensive overview of novel techniques and standard protocols to investigate the formation of vascular networks. The focus is on 1) methods to derive competent vascular cells from the differentiation of pluripotent stem cells; 2) vascular heterogeneity and protocols to generate organ- and tissue-specific vasculatures; 3) different bioengineering approaches to form functional vascular networks, including three-dimensional (3D) printing and microphysiological systems; and 4) methods to vascularize 3D engineered tissues as well as organoids.
Would you be interested in contributing? If you are, please submit an abstract here ( Abstract submission ).
JoVE (ISSN 1940-087X) is the leading peer-reviewed scientific methods video journal, aimed at increasing the visibility and reproducibility of research. JoVE is indexed in the major databases, including PubMed, EMBASE, Scopus, and Web of Science. JoVE's team will take care of the entire  process  of filming and producing your video.
If you need additional information, please contact either Juan Melero-Martin (Juan.MeleroMartin@childrens.harvard.edu ) or Kai Wang (Kai.Wang@childrens.harvard.edu).  
Thank you for your contribution!
New Journal
New journal 'JVS-Vascular Science' is online at jvsvs.org and accepting original papers.
This journal focuses on both basic and translational vascular science, and seeks to publish the best of "bench-to-bedside" translational research, underlying modern medical, endovascular and surgical investigation and management of vascular diseases.  NAVBO member Alan Dardik is the Editor, and several NAVBO members are on the Editorial Board, including Luke Brewster, Elliot L. Chaikof, Alan Daugherty, Raul J. Guzman, Ngan Huang, Bo Liu, Kathleen Martin, Xiaochun Long, William Sessa, and Jun Yu. JVS-Vascular Science is the 4th journal from the Society of Vascular Surgery and all journals are overseen by Editor in Chief Peter Gloviczki. An invitation is extended to all NAVBO members to participate; there are no fees for papers accepted during 2020. Email jvascsurg@vascularsociety.org for more information.

Job Postings
Have an opening to post?  Submit your open job post to the NAVBO Career Center - go to https://www.navbo.org/jobs.  Members receive a $150 discount on all postings, which makes our basic 30-day posting FREE for members.
Calendar of Events
July 12 - 14, 2020
ISTH 2020 Virtual Congress
Sept. 9 - 12, 2020
21st International Vascular Biology Meeting (IVBM 2020)
Oct. 3 - 6, 2020
11th Kloster Seeon Angiogenesis Meeting
Oct. 25 - 29, 2020
Vascular Biology 2020
Nov. 16 - 18, 2020
EMBO Workshop - Cell Signalling and Biology of Vascular Malformations
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211