December 12, 2019
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In This Issue
William R. Huckle, Editor
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September 9-12, 2020
Abstracts due Feb 29, 2020

Boston, MA
July 7-9, 2020
Vascular Biology 2020
Newport, RI
October 25-29, 2020

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Round Two!  Meet NAVBO Trainees
Hear what three more of our Travel Awardees have to say
Pictured are today's featured trainees receiving their awards from NAVBO Past-President Michelle Bendeck (left/center) and Kayla Bayless (right), co-organizer of the Vascular Matrix Biology and Bioengineering Workshop at VB2019.  This is our second installment, more to follow in future issues!

Rebecca Bolton, University College London
Kevin Boye, Yale School of Medicine
Emily Bramel, Johns Hopkins School of Medicine
It's the End of the Year Already!?
Holiday Gift Suggestion?

Why not share your enthusiasm for Vascular Biology with colleagues and staff. Purchase a NAVBO t-shirt for everyone in your lab!  Take a group photo and we'll feature your lab in the NewsBEAT  Profits from t-shirt purchases support our educational activities.

Go to to purchase items.  

Make a year end tax deductible contribution to NAVBO. Go to  Thank you for your support. 
Spotlight on Trainees
Coffee break as community builder
Vivienne Tam, a doctoral student at McGill University in Montreal, makes a palatable case in a recent Science feature that scientists should take more coffee breaks, embracing the opportunities to unwind and mingle informally with colleagues. During a research visit to France, Vivienne found the daily ritual of leaving the lab and gathering around the espresso machine not only refreshing, but also a setting for valuable brainstorming, hashing through research bottlenecks and the tribulations of trainee life in a non-judgmental environment. "The life of a scientist can feel isolating," she writes, "but it's much less isolating when you're connected to a supportive community."
Investigating ECFCs
Endothelial Colony-Forming Cells
David Smadja and Juan Melero-Martin are co-chairs of a committee on vascular biology (endothelial progenitor cells) at the International Society of Thrombosis and Hemostasis (ISTH), Scientific and Standardization Committee (SSC).
During one of the annual ISTH SSC meeting in Berlin, two years ago, a round table brought together international specialists from several groups and addressed questions regarding endothelial colony-forming cells (ECFCs). As a result, a position paper was written. Despite that effort, however, many more questions remained unanswered regarding the best methodologies for the use of ECFCs. 
The group is now trying to collect as much information as possible from laboratories that routinely work with ECFCs. Their goal is to identify and recommend standardized methods that are useful for the vascular biology community. 
To this end, a Google survey was created for those groups that routinely use human ECFCs. If this applies to you/your lab, please kindly complete the survey (it should take about 10 minutes to complete). 
The outcome of this survey will be reported to the SSC on Vascular Biology at the 2020 ISTH meeting in Milan, and the results will be submitted for publication to the Journal of Thrombosis and Haemostasis.
If you need more information, or if you encounter difficulties in registering, please contact David Smadja ( or Juan Melero-Martin (
There is a link on the ISTH webpage with more information about this survey. 
Your input is appreciated. 
Webinar Series Flourish through 2020
This month's webinar: Kristy Red-Horse 
Our December 19 webinar at 1:00pm  EST will feature Kristy Red-Horse of Stanford  University.  Her presentation is titled, " Coronary Artery Development and Regeneration."   
Follow this link to register:
Register for this webinar       

And Mark Your Calendar
The first webinar in 2020 will feature Mark Kahn, University of Pennsylvania, and his talk on
"The Gut-Brain Axis in Cerebral Cavernous Malformation." Plan to join us on January 24 at 1:00pm EST.  A link to the registration and web page will be available in our next NewsBEAT.

Our 2020 line up includes: Ke Yuan, Boston Children's Hospital; Brant Weinstein, NICHD/NIH; Courtney Griffin, Oklahoma Medical Research Foundation; Marlene Rabinovitch, Stanford University; Jason Fish, University of Toronto; Natasha Harvey, University of South Australia and Luisa Iruela-Arispe, Northwestern University.   
NAVBO Webinars are free to current NAVBO Members. Non-members can attend for $25 per webinar.   

And don't forget you can watch archived webinars as well - go to  
Special Issue on Vascular Signaling
Special Issue of Cell MDPI focusing on Vascular Signalling 
Drs. Silvia Dragoni and Patric Turowski, NAVBO Member, are the guest editors, and invite you to submit a contribution for this special issue. Submissions may be either a full paper or a communication based on research in any area of vascular biology, or it may be a focused review article.
Submissions are due March 30, 2020
  • MDPI Cells is an open access journal with a current IF of 5.7
  • Articles will be published immediately after acceptance
  • Colleagues may be eligible for discounted publication charges (limited availability on a first come first serve basis; please send an email to Dr. Turowski)
More information is available here:
If you plan to submit a review article please provide either editor or Janet Yan at the editorial office ( with a title and brief description at your earliest convenience, in order to avoid multiple reviews covering the same material.
The editors wish to be notified if you plan to submit a paper.
Patric Turowski - 
Silvia Dragoni -
Promote Your Presentation on the Web Site
Current NAVBO Members Can List Their Upcoming Presentations (Oral or Poster) on our Web Site
Keep members, and all who visit our web site, aware of presentations by NAVBO members.  If you are attending the meeting, be sure to attend your NAVBO colleague's presentation.  If you are also presenting at that meeting, you can attend each other's presentations and offer mutual support! It can also help make you aware when a colleague is in your town so you reach out and arrange an in-person chat. And finally, this listing can also keep you abreast of other relevant meetings and  conferences.

So check out the current listings: and add yours!
There is a form at the bottom of the page for you to add your presentation.
Member News
Welcome to our New Members:
Sera Nakisli, Ohio University
Harish Palleti Janardhan, University of Massachusetts Medical School

If you have news to share with your colleagues, send it to
Recent Publications by NAVBO Members

Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics
Scientific Reports
Upon inositol trisphosphate (IP3) stimulation of non-excitable cells, including vascular endothelial cells, calcium (Ca2+) shuttling between the endoplasmic reticulum (ER) and mitochondria, facilitated by complexes called Mitochondria-Associated ER Membranes (MAMs), is known to play an important role in the occurrence of cytosolic Ca2+ concentration ([Ca2+]Cyt) oscillations.  Read more


Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth
Clinical Science
OBJECTIVE: The role of chronic inflammation in abdominal aortic aneurysm (AAA) is controversial. CD11c+ antigen-presenting cells (APCs) (dendritic cells (DCs)) have been reported in human AAA samples but their role is unclear.  Read more


Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation
International Journal of Molecular Sciences
Atherosclerotic occlusive diseases and aneurysms that affect large and medium-sized arteries outside the cardiac and cerebral circulation are collectively known as peripheral arterial disease (PAD).  Read more


Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis
Journal of Experimental Medicine
Transendothelial migration (TEM) of leukocytes across the endothelium is critical for inflammation. In the endothelium, TEM requires the coordination of membrane movements and cytoskeletal interactions, including, prominently, recruitment of the lateral border recycling compartment (LBRC).  Read more


Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window
Biomedical Optics Express
We longitudinally imaged both the superficial and deep cortical microvascular networks in brains of healthy mice and in a mouse model of stroke in vivo using visible-light optical coherence tomography (vis-OCT).  Read more


Combining laser microdissection and microRNA expression profiling to unmask microRNA signatures in complex tissues
Neglecting tissue heterogeneity during the analysis of microRNA (miRNA) levels results in average signals from an unknown mixture of different cell types that are difficult to interpret.  Read more


The in vivo endothelial cell translatome is highly heterogeneous across vascular beds
Endothelial cells (ECs) are highly specialized across vascular beds. However, given their interspersed anatomic distribution, comprehensive characterization of the molecular basis for this heterogeneity in vivo has been limited.  Read more


Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension
American Journal of Respiratory and Critical Care Medicine
RATIONALE: Pulmonary (arterial) hypertension (PH/PAH) is a life-threatening cardiopulmonary disorder where inflammation and immunity have emerged as critical early pathogenic elements. Read more


Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease
Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ.  Read more

Industry News
Stem cells as magic bullet, placebo...or non-specific immune stimulant and repair accelerator?
Researchers have for years attempted, with limited success, to restore myocardial function by administering stem cells variously derived from embryos, reprogramming of terminally-differentiated cells, or isolated from adult heart. A recently published study in mice delivers a further blow to this idea, showing that modest beneficial effects of two types of cell therapy are caused not by the rejuvenating properties of stem cells, but a more ordinary wound-healing response that can also be triggered by injecting dead cells or immune activators into the heart. Writing in The Washington Post , Carolyn Johnson reviews the rollercoaster history of cardiac regeneration research, ending with the upbeat prospect that the immune system may be intentionally engaged to promote heart repair.

US Federal budget languishes - but you can help motivate your reps!
Lynn Marquis, Director of the Coalition for Life Sciences, reminds us in her December letter to CLS Grassroots Members that the failure of Congress to pass a budget for FY2020 has serious negative consequences for biomedical scientists who rely on federal agencies such as the NIH for research sponsorship. She appeals to us to contact our Congressional representatives, urging them to escape the cycle of short-term continuing budget resolutions and pass the annual budget legislation. Sample letter contents and a representative finder tool are available on the CLS website.
Job Postings
Calendar of Events
April 4 - 7, 2020
Experimental Biology 2020
July 7 - 9, 2020
Vasculata 2020
July 11 - 15, 2020
ISTH 2020 Congress
Sept. 9 - 12, 2020
21st International Vascular Biology Meeting (IVBM 2020)
Oct 25 - 29, 2020
Vascular Biology 2020
Partner Network Advantage on the NAVBO Job Board
Why post your job on NAVBO's career center rather than going directly to the larger job networks?
Pricing on the mass job boards can vary, but to get a job noticed you typically have to sponsor it for $5 - $10 per day, which can add up quickly especially since you also pay for each click the job gets. When you add it all together, you could be spending up to $45 per day on your job posting. But, when posting a job on NAVBO's career center, you simply pay a flat fee! The Premium package includes our Exclusive Extended Partner Network - which means the jobs are broadcast to sites like ZipRecruiter and Jobs2Careers and more for a flat fee.
With special member pricing, you can post a job for as low as $300 with this Partner Network. You never pay for each click, just the flat fee on the NAVBO career center. In addition, the Premium package includes a 60-day job posting making it a great value. The Premium packages also offer features like having your company's logo featured on the career center homepage, having your job appear first in search results, and more.
Post your open position now at!
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Part of the updates relate directly to the European Union's new General Data Protection Regulation (GDPR) that went into place May 25.   The GDPR seeks to improve the transparency of data usage and give end users more control over their own data. We believe these changes are important and will be compliant with the GDPR regulations.
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