July 25, 2019
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Partner Network Advantage - New Job Board Feature
Why post your job on NAVBO's career center rather than going directly to the larger job networks?
Pricing on the mass job boards can vary, but to get a job noticed you typically have to sponsor it for $5 - $10 per day, which can add up quickly especially since you also pay for each click the job gets. When you add it all together, you could be spending up to $45 per day on your job posting. But, when posting a job on NAVBO's career center, you simply pay a flat fee! The Premium package includes our Exclusive Extended Partner Network - which means the jobs are broadcast to sites like ZipRecruiter and Jobs2Careers and more for a flat fee.
With special member pricing, you can post a job for as low as $300 with this Partner Network. You never pay for each click, just the flat fee on the NAVBO career center. In addition, the Premium package includes a 60-day job posting making it a great value. The Premium packages also offer features like having your company's logo featured on the career center homepage, having your job appear first in search results, and more.
Post your open position now at www.navbo.org/jobs! 
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NAVBO Privacy Policy
Your data privacy and security are important to NAVBO. To that end, we have updated our privacy policy to reflect recent privacy and security regulation implementations and changes. Please review our policy as time permits so you have a complete understanding of the data we have, why we have it, and how we use it.
Part of the updates relate directly to the European Union's new General Data Protection Regulation (GDPR) that went into place May 25.   The GDPR seeks to improve the transparency of data usage and give end users more control over their own data. We believe these changes are important and will be compliant with the GDPR regulations.
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Meet One of Our New Council Members
Cynthia St. Hilaire, Ph.D.
Dr. St. Hilaire is an Assistant Professor of Medicine at the University of Pittsburgh in the Division of Cardiology and is a faculty member of the Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute. She received her BS in Molecular Genetics from the University of Vermont and conducted graduate studies at Boston University School of Medicine, where she earned her PhD in Biochemistry studying the role of adenosine receptor signaling in vascular biology under the mentorship of Dr. Katya Ravid. Her postdoctoral studies were performed at the NHLBI with Dr. Manfred Boehm where they worked with the Undiagnosed Diseases Program and together discovered the genetic cause of the rare disease that links the enzyme CD73 and adenosine signaling to vascular calcification and vessel tortuosity.
The research program in her lab focuses on characterizing the underlying pathobiology of vascular disease, concentrating on mechanisms that drive vascular and valvular calcification and extracellular matrix remodeling. The lab's long-term goals are to characterize how mechanical and inflammatory cues induce epigenetic and protein modifications that induce the transformation of a healthy vascular cell into a calcifying cell.
Dr. St. Hilaire is passionate about training the next generation of scientists and even more passionate about breaking down the barriers and biases that have contributed to the gender and racial disparities seen in academic science and medicine. For more information please visit the St. Hilaire Lab Website: www.sthilairelab.pitt.edu
Good News for NIH Budget
Federal budget agreement augurs increased research funding
Research!America President and CEO Mary Woolley has issued a statement applauding the bipartisan agreement reached on the Federal budget for fiscal years 2020 and 2021. Included in the agreement are plans for increased appropriations for the National Institutes of Health, the Centers for Disease Control and Prevention, the Food and Drug Administration, the Agency for Healthcare Research and Quality, the National Science Foundation, and other federal agencies whose missions are to guide public resources to increase the public good.
Upcoming Webinars
NAVBO Continues to Bring You Exciting Webinars 
On August 1 at 1:00pm, Masanori Aikawa of Brigham & Women's Hospital and Harvard Medical School will present his talk entitled, "Exploring New Mechanisms for Macrophage Activation: A Systems Approach."   
Pro-inflammatory activation of macrophages contributes to the pathogenesis of atherosclerosis; however, its underlying mechanisms are incompletely understood.  Despite the availability of potent drugs for modifiable risks, complications of atherosclerosis remain global health threats.  To challenge residual risk, Dr. Aikwawa's laboratory explores novel mechanisms for macrophage activation as an important first stride towards the development of new therapies.  Register for this webinar 

Upcoming Webinars: 
September 12 - Carlos Fernández-Hernando, Yale School of Medicine 
October 10 - Sathish Srinivasan, Oklahoma Medical Research Foundation  

NAVBO Webinars are free to current NAVBO Members.
And don't forget you can watch archived webinars as well - go to  
NAVBO Travel Awards to the GRC
Congratulations to our Award Winners!
Redouane Aherrahrou of Mete Civelek's lab at the University of Virginia was the recipient of the NAVBO Travel Award to the 2019 Atherosclerosis Gordon Research Conference.  Pictured here at the conference with Dr. Carlos Fernández-Hernando, one of the conference chairs.

We are also pleased to announce that the recipient of the NAVBO Travel Award to the 2019 GRC on Angiogenesis is Kazuhide Okuda of Dr. Benjamin Hogan's lab at the University of Queensland. 

Congratulations to you both!
NEW!!!  VB2019 Grants for Child Care
NAVBO announces grants to support child care expenses
The NAVBO Council voted to support grants for family members who may need additional support when attending a meeting.  Go to http://www.navbo.org/events/vb2019/childcare19/childcareinfo for more information and to apply.

Help support these grants by purchasing a Vascular Biology networking T-shirt or by giving a donation.  NAVBO will support five grants at $400 each;  all funds raised in this manner, even if above $2,000, will support these grants.  Thank you for your support.
Buy a T-shirt (or mug)
Make a donation (Select quantity 1 for $25; quantity 2 for $50, etc.)
Lab of the Month
The Lab of Ngan F. Huang

This month we are highlighting the lab of Dr. Ngan Huang, an Assistant Professor in the Department of Cardiothoracic Surgery at Stanford University. Find out more about Dr. Huang and her lab at  http://www.navbo.org/membership/members-labs/815-lab072019.  
Lessons Learned
Ngan Huang
My name is Ngan F. Huang, PhD and I have been an Assistant Professor in the Department of Cardiothoracic Surgery at Stanford University since 2013. Many people consider the milestones of a successful Assistant Professor to include: publishing high impact papers, receiving grants, getting top teaching evaluations, serving on grant review panels, becoming nationally recognized by peers, obtaining leadership positions in service organizations, becoming journal editors, and receiving achievement awards. However, these milestones can be challenging and even overwhelming. I remember feeling lost as a brand new faculty member, not knowing how I would eventually be able to reach these milestones towards securing tenure. Now, six years later, I would like to share some of the progressive steps I took towards reaching these milestones.
Years 1 & 2: Setting up the laboratory and developing thick skin for rejection. I consider the first two years as being simultaneously the easiest as well as most challenging years of being an Assistant Professor. The reason for being the easiest is because new faculty would already know that the initial tasks are to establish your laboratory, purchase any necessary equipment that cannot be borrowed, hire your first trainees, and start teaching. Although the process of doing these tasks can be daunting, at least every new faculty already knows these initial responsibilities. On the other hand, the most challenging aspect of the first two years is in getting that first grant without leaning on the shoulders of your former mentor. Writing a fundable grant requires first and foremost good ideas, and getting that first grant is to affirm your ability to develop novel ideas and to build self-confidence. Therefore, the first two years are like a testing ground to get feedback from reviewers about your ideas. Some ideas might be met with enthusiasm, and other ideas will be harshly criticized. This seemingly endless cycle of writing grants and then learning of the funding outcome is like a filtration process-separating the non-fundable ideas from those that stand a chance. Although these rejections can provide some constructive feedback on potential improvements to your ideas, it may feel very disappointing at times.  In times of receiving rejection, my advice for new faculty is to persevere and not give up. When facing rejection, take a break to seek support from colleagues who have gone through the same experience. At a later point, revisit the reviewer comments to identify ways to improve the quality of the proposal, or possibly to approach the same question from a different angle. As an example, I once took the well-received elements of a non-funded R01 grant and submitted it as a R21 grant, which was later funded. Also consider alternative funding agencies that might be more receptive to your ideas. Being able to grow from writing non-funded grants is a necessary aspect of academia. Keep writing and refining your ideas. Do not be afraid of rejection, as your skin will adapt with time by thickening.
Years 3 & 4: Becoming visible in your field and getting that elusive major grant.
Most new faculty members already have training in writing manuscripts and grants, but many people have never learned about becoming visible in the research community. I used to think that publishing high impact papers was the only way to get invited as a speaker at conferences or to become an editor of a journal. I realized a few years into my faculty position that taking an active role to becoming visible in the field is more effective and more fun. Whereas in the first two years I was predominantly focused on attending research conferences, by the third year I began to actively organize conference sessions, volunteer for service committees, and distribute my CV to program officers for consideration as a grant reviewer. Becoming actively involved in societies or service organizations is helpful towards becoming recognized for both research and service in the research community. In the process of organizing conference sessions, you will meet other colleagues, some of whom may one day be a reviewer on your manuscripts or grants. Social media is also emerging as a highly effective way to meet colleagues and publicize your latest research findings.  .  .  . 
Promote Your Presentation on the Web Site
Current NAVBO Members Can List Their Upcoming Presentations (Oral or Poster) on our Web Site
Keep members, and all who visit our web site, aware of presentations by NAVBO members.  If you are attending the meeting, be sure to attend your NAVBO colleague's presentation.  If you are also presenting at that meeting, you can attend each other's presentations and offer mutual support! It can also help make you aware when a colleague is in your town so you reach out and arrange an in-person chat. And finally, this listing can also keep you abreast of other relevant meetings and  conferences.

So check out the current listings: http://www.navbo.org/membership/meeting-presentations-by-members and add yours!
There is a form at the bottom of the page for you to add your presentation.
Spotlight on Trainees
Congratulations to our Vasculata Poster Award Recipients!
At this year's Vasculata, held at the Medical College of Wisconsin, five posters were judged to be outstanding.  Pictured here with Dr. Calvin Williams, Associate Dean of Research and Associate Director, Medical Scientist Training Program, are Sarah Proudfoot, Rachel Jones Lipinski, Javier Abello and Sohni Bhalla (Matthew Rappelt was not available for the photo)
Participants enjoyed sessions, workshops, posters and a boat tour of Milwaukee!  Many thanks to Dr. Ramani Ramchandran and his organizing team for another successful Vasculata!!    
Call for Papers - Single-Cell Anaylysis
A Frontiers Research Topic initiated by NAVBO
Recent advances in analyzing tissues and organs at the single cell (SC) level are revolutionizing our understanding of organ development, biology, and disease. Previously, the genetic composition or transcriptional profiles of cells was based on sequencing DNA or RNA from a large number of cells, but this approach loses information on the heterogeneity of individual cells. Sequencing DNA and RNA from individual cells preserves heterogeneity, and technological advances have made these techniques highly accessible.

A recent analysis - available here - of the SC extramural research funded by the NIH, either through NIH-initiated programs focused on SC or initiated by extramural investigators, revealed the paucity of such analyses related to vascular cells compared to a variety of other cells and tissues. This Research Topic is seeking to galvanize interest in SC applications related to the field of vascular cell biology and highlight original research related to SC analyses of vascular related cells, under normal or diseased conditions. We seek to understand the specific challenges associated with studying vascular cells, and how advances in SC approaches could benefit vascular fields. Submissions are due September 30, 2019. More information can be found here on the Frontiers web site.
Member News
Welcome to our New Members:
Suhaas Anbazhakan, Stanford University
Rebecca Bolton, University College London
Denver Britto, University of Auckland
Claire Dessalles, Ecole Polytechnique
Aarren Mannion, Karolinska Institutet
Kirsty Naylor, University College London
Navaneeth Krishna Rajeeva Pandian, Texas A&M University
Ragini Phansalkar, Stanford University
Ryan von Kleeck, University of Pennsylvania

If you have news to share with your colleagues, send it to membership@navbo.org
 Recent Publications by NAVBO Members

Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal
Scientific Reports
Elevated triglyceride-rich lipoproteins (TGRL) in circulation is a risk factor for atherosclerosis. TGRL from subjects consuming a high saturated fat test meal elicited a variable inflammatory response in TNFa-stimulated endothelial cells (EC) that correlated strongly with the polyunsaturated fatty acid (PUFA) content.  Read more


Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms
Frontiers in Immunology
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Endothelial cells (EC) are actively involved in sepsis-associated (micro)vascular disturbances and subsequent organ dysfunction.  Read more


Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations
Background: The cells that form the arterial wall contribute to multiple vascular diseases. The extent of cellular heterogeneity within these populations has not been fully characterized.  Read more


Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis
Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research has focused on the impact of blood-derived monocytes on cardiac repair.  Read more

Industry News (from our July 11 issue)
White House effort on drug price disclosures hits judicial snag
The US District Court in the District of Columbia ruled this week that the Trump administration cannot force pharmaceutical companies to disclose the list price of their drugs in television ads.  The president has pressured drug companies to lower their prices, a populist issue for the administration and members of Congress.  The effort to provide transparency in drug pricing is seen as largely symbolic; HHS Secretary Alex M. Azar II has argued that requiring such disclosure could shame the drugmakers into lowering their prices.  Bipartisan legislation in Congress would limit out-of-pocket costs for people covered by Medicare and allow the federal government to directly negotiate the price of drugs. 
Shifting funding priorities in stem cell research
Jocelyn Kaiser, writing in Science magazine, reports that the California Institute for Regenerative Medicine, created in 2004 with a $3 billion state research allocation, is no longer taking grant applications. The CIRM ballot initiative followed then-President George W. Bush's administration move to curtail the use of federal funding for studies of stem cells derived from human embryos. Although CIRM initially focused on human embryonic stem cells, projects came to encompass research on adult stem cells and induced pluripotent stem cells, created by reprogramming adult cells to an embryolike state. 

Investigation of diet-related canine cardiomyopathy continues
In late June, the US Food and Drug Administration issued an update on its investigation into reports of dilated cardiomyopathy in dogs consuming "grain-free" diets, containing a relatively high proportion of legume seeds and/or potatoes as main ingredients. Between January 1, 2014, and April 30, 2019, the FDA received 524 reports of DCM from pet owners and veterinarians.  The mechanistic details of the association between diet and DCM remain unclear.  Although some dog breeds have a genetic predisposition to DCM, the reports submitted to the FDA span a wide range of breeds, including many without a known genetic predisposition.

Job Postings
Calendar of Events
August 4 - 9, 2019
2019 Angiogenesis Gordon Conference
Sept. 16 - 18, 2019
Critical Issue in Tumor Microenvironment: Angiogenesis, Metastasis, and Immunology
Sept. 26 - 27, 2019
2019 NHLBI Mitochondrial Biology Symposium
Oct 27 - 31, 2019
Vascular Biology 2019
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
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