December 8, 2016 
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NAVBO members receive discounts on registration to IVBM 2016
Look inside the IVBM Virtual Conference Bag

Lymphatic Forum
in Chicago, IL
June 8-10, 2017

Vascular Biology 2017
Monterey, CA
October 15-19 

Vasculata 2017

Chicago, IL
August 7-10, 2017
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Meet the Professor Breakfasts Supported by

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Host the 2018 Vasculata
If you are interested in hosting Vasculata 2018 at your institution, please see the information on our web site and send in your application by January 20.  Go to to download the proposal form.
Holiday Shopping and End of Year Giving
Consider supporting NAVBO this year.
1) If you shop at Amazon - please go to Amazon using this link:    You shop and .5% of your purchase will go to support NAVBO.

2) Make a year-end tax deductible contribution - NAVBO is designated as a 501(c)3 organization by the IRS and therefore, your contribution to NAVBO is tax deductible.  Please donate here: .  You can stipulate that your donation be used for Travel Awards to the IVBM, Scholarships to the Vasculata Summer Course or NAVBO Programs.

Thank you!
Lab of the Month
The Lab of Dr. Matthew Spite

This month we are highlighting the lab of Dr. Matthew Spite, who is an Assistant Professor at Harvard Medical School and in the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital. Find out more about Dr. Spite's lab at

Spotlight on Trainees (from our November 28 issue)
Obstacles faced by female scientists  
Hannah Valantine, MD, Chief Officer for Scientific Workforce Diversity at the NIH, has authored an article in the December 2016 issue of Scientific American , highlighting the need for a culture change to lower barriers that impede the career advancement of female scientists. She notes the many hurdles currently in place, such as indicators of bias from grant reviewers, stigma attached to family-related leave, and unequal compensation. Dr. Valantine notes that the "...failure to eliminate the inequities facing women in science would represent a failure for women and men alike, as well as for the enterprise of biomedical research." Approaches to reducing gender bias have also been described by Dr. Valantine and her colleagues at Stanford, UVa, Apple, and Implisci.
 Recent Publications by NAVBO Members

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
Nature Communications
In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide RNAi screen was performed in endothelial cells and cross-referenced with GWAS-data sets.  Read more


Control of mitochondrial function and cell growth by the atypical cadherin Fat1
Mitochondrial products such as ATP, reactive oxygen species, and aspartate are key regulators of cellular metabolism and growth. Abnormal mitochondrial function compromises integrated growth-related processes such as development and tissue repair, as well as homeostatic mechanisms that counteract ageing and neurodegeneration, cardiovascular disease, and cancer.  Read more


Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression
Journal of Biomechanics
Epigenetics is the regulation of gene expression (transcription) in response to changes in the cell environment through genomic modifications that largely involve the non-coding fraction of the human genome and that cannot be attributed to modification of the primary DNA sequence.  Read more


Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency
American Journal of Pathology
The vasculature influences the progression and resolution of tissue inflammation. Capillaries express vascular endothelial growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid flow. NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascular and lymphatic endothelia.  Read more


Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice
Nature Communications
Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as a potent activator for various types of immune cells through its specific membrane receptors LPA1/3. LPA elicits chemotactic, pro-inflammatory and apoptotic effects that lead to atherosclerotic plaque progression.  Read more


PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Nature Communications
Activin receptor-like kinase 1 (ALK1) is an endothelial serine-threonine kinase receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene cause hereditary haemorrhagic telangiectasia type 2 (HHT2), a disabling disease characterized by excessive angiogenesis with arteriovenous malformations (AVMs).  Read more


Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition
Cardiovascular Research
Aims: Extracellular nucleotides and adenosine that are formed or degraded by membrane-bound ecto-enzymes could affect atherosclerosis by regulating the inflammation and thrombosis. This study aimed to evaluate a relation between ecto-enzymes that convert extracellular adenosine triphosphate to adenine dinucleotide phosphate, adenosine monophosphate, adenosine, and inosine on the surface of the vessel wall with the severity or progression of experimental and clinical atherosclerosis.  Read more


Fzd7 (Frizzled-7) Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/ß-Catenin Canonical Signaling
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective-Vessel formation requires precise orchestration of a series of morphometric and molecular events controlled by a multitude of angiogenic factors and morphogens. Wnt/frizzled signaling is required for proper vascular formation.  Read more

Industry News (from our November 28 issue)
Immune system/cardiovascular interactions at Experimental Biology 2017
The American Physiological Society Cardiovascular Section, in conjunction with the journal Clinical Science (Portland Press), will sponsor a "Featured Topic" the Experimental Biology 2017 meeting in Chicago: 1006-APS - Immune Cells Involved in Cardiovascular Disease, scheduled for Sunday, April 23, 2017, 3:15 PM - 5:15 PM.Session organizers Brett Mitchell and Meena Madhur invite submission of research characterizing immune cell involvement in the development of all forms of cardiovascular disease. Six abstracts will be selected for 10 minute talks that will follow Dr. Ernesto Schiffrin's talk entitled "Immune Cells in Hypertension: The Good, the Bad, and the Ugly". In addition, the Editorial Board of Clinical Science invite all Featured Topic presenters to submit an article related to their abstract to the journal to be considered for publication.
What lies ahead for NIH under the incoming federal administration? 
A working group of leading scientists, chaired by Keith Yamamoto, PhD, Vice Chancellor for Science Policy and Strategy at UCSF, has released a report for the new administration, containing recommendations on how best to ensure continued progress in biomedical research conducted with support of the NIH. The group, which includes former NIH directors Harold Varmus, MD, and Elias Zerhouni, MD, recommends the appointment of an NIH Director within the first hundred days of the new administration, and also emphasizes the importance of basic research, training opportunities, and an assessment of the NIH's Institute and Center structure, currently based on organs and disease.
Job Postings
Job Title
Chicago, IL
Assistant/Associate/Full Professor - Physiology and Biophysics
University of Illinois at Chicago
Chicago, IL
Paris, France
Postdoctoral Researcher
University of Virginia
Charlottesville, VA
Calendar of Events
June 8-10, 2017
Lymphatic Forum 2017
Aug. 7-10, 2017
Vasculata 2017
Oct. 15-19, 2017
Vascular Biology 2017
June 4-7, 2018
20th International Vascular Biology Meeting
Collaborating Societies at the IVBM

North American Vascular Biology Organization | |
18501 Kingshill Road
Germantown, MD 20874-2211