October 13, 2016 
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NAVBO members receive discounts on registration to IVBM 2016
Look inside the IVBM Virtual Conference Bag

Lymphatic Forum
in Chicago, IL
June 8-10, 2017

Vascular Biology 2017
Monterey, CA
October 15-19 
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IVBM 2016 Tee-Shirts!!
Today is the Last Day to Purchase Your IVBM 2016 Shirt!! 
Help support Trainee Travel Awards to the 2018 IVBM in Helsinki by buying a t-shirt (or other apparel) commemorating the 2016 IVBM in Boston.  Short and long sleeve t-shirts, hoodies and even a mug are available in your choice of gray or white. 

To place an order go to http://www.teespring.com/IVBM2016-tees
Only two weeks to the IVBM!!!
19th International Vascular Biology Meeting 
Boston - October 30-November 3
Register online through October 28
(onsite registration will be available, late fee of $50 will apply)

Additional information about child care, traveling around Boston, etc. can be found here: http://www.ivbm2016.org/hotel
Lab of the Month
The Lab of Dr. Daniela Simona Ardelean

This month we are highlighting the lab of Dr. Daniela Simona Ardelean of the University of Western Ontario. Find out more about Dr. Ardelean's lab at  http://www.navbo.org/membership/members-labs/541-lab102016.

Lessons Learned (from Sept 29 issue)
Remember why you are doing science
By Daniela Simona Ardelean, University of Western Ontario

Do you remember the day when you thought that science is really cool and that this is what you want to do, no matter what? For some, it was a defined moment; for others, a longer, slow process. Some people could explain it, others just knew it. But for all, the knowledge or feeling (yes, it can be either one) that doing science is the right thing, was the same. You just knew. Remember that when you come across challenges that may seem insurmountable.

I am a pediatric rheumatologist who is doing translational research. Since I have started one year ago as a junior faculty at the Schulich School of Medicine and Dentistry at University of Western Ontario in London, Ontario, Canada, I have been working towards establishing my lab and building the team. This is still work in progress.

The transition from trainee to faculty is often lengthy and difficult. On this journey, I have learned a few things that I would like to share with you:

Think early about your research program.

Connect with
peers and scientists outside your discipline.
Find out what funding opportunities are available at your institution(s).
We need time for reflection.
Writing is about telling stories that matter to you and others.

Despite the long path, challenges, ups and downs, we are privileged to do research. Remember why you chose science and make the most of your journey.

Read this article in full at http://www.navbo.org/resources/lessons-learned 
Member News
Vein Graft Symposium
This free meeting, organized by NAVBO members, Masanori Aikawa and C. Keith Ozaki, is taking place October 28 at Brigham and Women's Hospital, Boston.  If you are interested in attending or would like more information, click here .
Welcome our new members:
Anthony Barnes, Oregon Health and Science University
Alexander Caulk, Yale University
Charan Devarakonda, UConn Health
Peng Guo, Boston Children's Hospital and Harvard Medical School
Sarah Higgins, BIDMC, Harvard Medical School
Arshad Rahman, University of Rochester
Steven Swendeman, Boston Children's Hospital
Paul Yu, Brigham and Women's Hospital, Harvard Medical School

If you have news to share with your colleagues, send it to membership@navbo.org.
Spotlight on Trainees (from Sept 29 issue)
The halcyon days of a post-doc
Hard on the heels of   National PostDoc Appreciation Week , Science magazine has published a set of anecdotes from current post-docs, as well as scientists who have recently made the jump to their first faculty appointments. These vignettes offer tips for career advancement and the occasional bit of 20-20 hindsight regarding surprises encountered and road-not-taken choices that may have paid off. As is often the case in this era of online discourse, the comments appended to the article are equally enlightening, providing some balance to the success stories.

 Recent Publications by NAVBO Members

Exercise capacity and cardiac hemodynamic response in female ApoE/LDLR(-/-) mice: a paradox of preserved V'O2max and exercise capacity despite coronary atherosclerosis
Scientific Reports
The authors assessed exercise performance, coronary blood flow and cardiac reserve of female ApoE/LDLR(-/-) mice with advanced atherosclerosis compared with age-matched, wild-type C57BL6/J mice. Exercise capacity was assessed as whole body maximal oxygen consumption (V'O2max), maximum running velocity (vmax) and maximum distance (DISTmax) during treadmill exercise.  Read more


Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice: A Comparison with Nicotinic Acid
Journal of Pharmacology and Experimental Therapeutics
1-Methylnicotinamide (MNA), the major endogenous metabolite of nicotinic acid (NicA), may partially contribute to the vasoprotective properties of NicA. Here we compared the antiatherosclerotic effects of MNA and NicA in apolipoprotein E (ApoE)/low-density lipoprotein receptor (LDLR)-deficient mice. ApoE/LDLR(-/-) mice were treated with MNA or NicA (100 mg/kg).  Read more


1-methylnicotinamide and its structural analog 1,4-dimethylpyridine for the prevention of cancer metastasis
Journal of Experimental and Clinical Cancer Research
BACKGROUND: 1-methylnicotinamide (1-MNA), an endogenous metabolite of nicotinamide, has recently gained interest due to its anti-inflammatory and anti-thrombotic activities linked to the COX-2/PGI2 pathway. Given the previously reported anti-metastatic activity of prostacyclin (PGI2), we aimed to assess the effects of 1-MNA and its structurally related analog, 1,4-dimethylpyridine (1,4-DMP), in the prevention of cancer metastasis.  Read more


Alterations in plasma biochemical composition in NO deficiency induced by L-NAME in mice analysed by Fourier Transform Infrared Spectroscopy
Journal of Biophotonics
Mouse model of nitric oxide deficiency, induced by prolonged treatment with NG -nitro-L-arginine methyl ester (L-NAME) was used for infrared spectroscopy (FTIR) analysis of plasma. L-NAME leads to increased peripheral resistance and systemic hypertension.  Read more


3D Raman imaging of systemic endothelial dysfunction in the murine model of metastatic breast cancer
Analytical and Bioanalytical Chemistry
It was recently reported in the murine model of metastatic breast cancer (4T1) that tumor progression and development of metastasis is associated with systemic endothelial dysfunction characterized by impaired nitric oxide (NO) production. Using Raman 3D confocal imaging with the analysis of the individual layers of the vascular wall combined with AFM endothelial surface imaging, we demonstrated that metastasis-induced systemic endothelial dysfunction resulted in distinct chemical changes in the endothelium of the aorta.  Read more


1-Methylnicotinamide protects against liver injury induced by concanavalin A via a prostacyclin-dependent mechanism: A possible involvement of IL-4 and TNF-α
International Immunopharmacology
The authors have recently demonstrated that concanavalin A (Con A)-induced hepatitis is associated with the release of endogenous 1-methylnicotinamide (MNA). Here the authors study the mechanism by which exogenous MNA alleviates Con A-induced liver inflammation and injury in vivo.  Read more


Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo
Scientific Reports
Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1 (Atox1) in the cytosol supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus functions as a Cu-dependent transcription factor. Using mouse cutaneous wound healing model, here we show that Cu content (by X-ray Fluorescence Microscopy) and nuclear Atox1 are increased after wounding, and that wound healing with and without Cu treatment is impaired in Atox1-/- mice.  Read more

Plan to Attend - Exhibitor Showcases at the IVBM
Exhibitor Showcases at the IVBM - Boston

Monday, October 31 from 5:15-6:15pm
Protocols for Measuring Endothelial Barrier Function with ECIS
(from TEER across transwell filters to large scale screens on 96 well plates)
Presentation by Dr. Christian Renken, Applied BioPhysics

Wednesday, November 2 from 4:00-5:00pm

Monday, October 31 from 4:00-5:00pm
Targeted proteomics performed on the Q Exactive permits to study the metabolism of circulating apolipoproteins
Sasha A. Singh, Director of Proteomics Center for Interdisciplinary Cardiovascular Sciences Brigham and Women's Hospital, Boston, MA
Translational Proteomics Workflows for Extending the Profiling Range of Plasma/Serum
Scott Peterman and David Sarracino Thermo Fisher Scientific BRIMS, Cambridge, MA
Tuesday, November 1 from 4:00-5:00pm 
Unlocking Translational Biomarkers in Vascular Biology with Ultra High Frequency Ultrasound 
Presentation by Dr. Julius Decano, Brigham and Women's Hospital 

Industry News (from Sept 29 issue)
Lasker Prizes awarded for research on mechanisms of response to hypoxia
William Kaelin (Harvard Medical School), Peter Ratcliffe (University of Oxford) and Gregg Semenza (Johns Hopkins) have been named recipients of the 2016 Albert Lasker Basic Medical Research Awards , in recognition of their "...discovery of the pathway by which cells from humans and most animals sense and adapt to changes in oxygen availability - a process essential for survival." The importance of hypoxia-inducible factors, key components of the pathways characterized by the awardees, is well known to investigators of angiogenesis, erythropoiesis, and energy metabolism. Congratulations and well-deserved, Drs. Kaelin, Ratcliffe, and Semenza!
Bioengineered tissue patches for cardiac repair
A new grant from the National Heart, Lung, and Blood Institute will support researchers at the University of Alabama-Birmingham, the University of Wisconsin-Madison, and Duke University in their effort to develop tissue engineered patches that can be applied to repair of infarcted cardiac muscle. This grant is part of the second round of the Progenitor Cell Translational Consortium U01 funding, whose objective is to promote cooperative research agreements among institutions to develop cell therapies for the heart, lung and blood.
David C. Goff, Jr., named Director of the NHLBI Division of Cardiovascular Sciences
NHLBI Director Gary Gibbons has announced the appointment of distinguished cardiovascular epidemiologist David C. Goff, Jr., M.D., Ph.D., as the  next Director of the Institute's Division of Cardiovascular Sciences , effective November 28, 2016. Dr. Goff comes to the NIH from the Colorado School of Public Health, where he has served as Dean since 2012. Prior to that, he was Chair of the Department of Epidemiology and Prevention in the Division of Public Health Sciences at Wake Forest University School of Medicine. In addition to his work as an investigator in academe, Dr. Goff has provided scientific direction for critical efforts across NIH, including membership on NHLBI Guideline Executive Group and as Co-Chair of the NHLBI Risk Assessment Working Group.
Job Postings
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Thomas Jefferson University
Philadelphia, PA
Acute Care Nurse Practitioner
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Charlottesville, VA
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Pittsburgh, PA
Calendar of Events
Oct. 28 Brigham and Women's Hospital Vein Graft Symposium
Oct. 30 - Nov. 3 19th International Vascular Biology Meeting
Nov. 13-16 American Society for Matrix Biology Biennial Meeting
June 8 - 10 Lymphatic Forum 2017
Oct. 15-19 Vascular Biology 2017
Collaborating Societies at the IVBM

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