Lymphatic Forum
in Chicago, IL
Vasculata 2017
Chicago, IL
July 24-27, 2017
Abstract deadline: June 1
October 15-19, 2017
Abstract deadline: Aug 1
20th IVBM
Helsinki, Finland
June 3-7, 2018
|
Diamond Level
Welcome Reception Host
|
|
|
 |
Vasculata Opportunities
Scholarship and Travel Award Applications are due June 1
With the help of funding from the NIH, the University of Illinois at Chicago (UIC) is able to offer scholarships for Vasculata attendees who do not have available funding for travel from their institution.
We will also provide five travel awards ($500 each) to students or postdoctoral fellows who belong to an under-represented minority (African American, Latino, Native American) and are interested in the field of vascular biology and/or attending Vasculata. NAVBO and the UIC seek to attract talented young investigators to ensure a diverse and highly trained workforce that will be available to assume leadership roles in research.
See http://www.navbo.org/events/vasculata-2017/scholarships for details.
Abstract Deadline is also June 1!
If you are planning to attend Vasculata, we encourage you to submit an abstract. This is a wonderful opportunity to gain experience in presenting your work and receive feedback on your presentation.
Other Deadlines to Watch For
Meritorious Award Nominations
Submission deadline is July 8
Vascular Biology 2017
Abstract deadline - August 1
Early bird discount - August 15
|
The Lab of Dr. Karen Hirschi
 This month we are highlighting the lab of Dr. Karen Hirschi, who is a
Professor in the Departments of Medicine, Genetics and Biomedical Engineering and Co-Director of the Cardiovascular Research Center at the Yale University School of Medicine. Find out more about Dr. Hirschi and her lab at
http://www.navbo.org/membership/members-labs/606-lab052017.
|
|
Spotlight on Trainees
(from the May 11 issue)
|
Entries Invited for New Award in Regenerative Medicine and Cell Therapy
Sartorius & Science Prize for Regenerative Medicine & Cell Therapy is an annual prize geared towards researchers focused on basic or translational research that advances regenerative medicine and cell therapy. Established in 2017, the prize is awarded for outstanding research performed by the applicant and as a mutual endeavor to raise awareness for the field and its fundamental significance for our future.
The winner is awarded US$25,000 and a publication of his or her essay in
Science. This Grand Prize essay and those of up to three runners-up are also published on
Science Online. Awarded fields include regenerative medicine, cell therapy, gene therapy, immunotherapy as well as materials and tissue engineering. An individual scientist who received his or her PhD/MD within the past 10 years may apply.
|
The research of
Dr. Kari Alitalo, Academy Professor in the Translational Cancer Biology Research Program at the University of Helsinki and one of the principal organizers of IVBM 2018, was prominently featured in a
recent article in
The Washington Post. The
Post report explores implications of Dr. Alitalo's finding, together with Swiss and Norwegian collaborators, of evidence for an organized
lymphatic system serving the brain. The description of lymphatic vessels by Dr. Alitalo and other scientists working independently in the U.S. has opened new avenues for exploring mechanisms of Alzheimer's, Huntington's, and Parkinson's Diseases, as well as other neurodegenerative and autoimmune disorders.
|
Welcome to our Newest Member:
Bandana Singh, Blood Research Institute/BloodCenter of Wisconsin
|
|
Recent Publications by NAVBO Members
|
| Functional and Biochemical Endothelial Profiling In Vivo in a Murine Model of Endothelial Dysfunction; Comparison of Effects of 1-Methylnicotinamide and Angiotensin-converting Enzyme Inhibitor
Frontiers in Pharmacology
Although it is known that 1-methylnicotinamide (MNA) displays vasoprotective activity in mice, as yet the effect of MNA on endothelial function has not been demonstrated in vivo. Read more Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries
American Journal of Physiology - Heart and Circulatory Physiology
The impact of disease related changes in the extracellular matrix (ECM) on the mechanical properties of human resistance arteries largely remains to be established. Resistance arteries from both pig and human parietal pericardium (PRA) display a different ECM microarchitecture compared to frequently used rodent mesenteric arteries. Read more Tissue-engineered 3D human lymphatic microvascular network for in vitro studies of lymphangiogenesis
Nature Protcols
This protocol describes a unique in vitro method for the generation of a 3D human lymphatic network within native connective tissue devoid of any exogenous material such as scaffolds or growth factors. Read more Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis
Diabetes
Proliferative diabetic retinopathy (PDR) is a common cause of blindness in the developed world's working adult population, and affects those with type 1 and type 2 diabetes mellitus. Read more Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis
Neuron
The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. An unusually low rate of vesicular transport (transcytosis) has been identified as one of the two unique properties of CNS endothelial cells, relative to peripheral endothelial cells, that maintain the restrictive quality of the BBB. Read more Development of the larval lymphatic system in the zebrafish
Development
The lymphatic vascular system is a hierarchically organized complex network essential for tissue fluid homeostasis, immune trafficking, and absorption of dietary fats in the human body. Despite its importance, the assembly of the lymphatic network is still not fully understood. Read more Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow
Journal of the Royal Society Interface
Local haemodynamics are linked to the non-uniform distribution of atherosclerosic lesions in arteries. Low and oscillatory (reversing in the axial flow direction) wall shear stress (WSS) induce inflammatory responses in endothelial cells (ECs) mediating disease localization. Read more Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS induced ROS release in coronary artery disease
Microcirculation
OBJECTIVES: Hydrogen peroxide (H2 O2 ) contributes to flow-induced dilation (FID) of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase contributes to mitochondrial ROS generation in arterioles during coronary artery disease (CAD). Read more |
|
Industry News
(from the May 11 issue)
|
NIH Common Fund Invites Applications for High-Risk, High-Reward Research Awards
In late April, the NIH opened applications for the NIH Director's Common Fund high-risk, high-reward research program, including: Transformative Research Awards, Pioneer Award Program, New Innovator Award Program, and Early Independence Awards. These awards aim to attract exceptionally creative scientists proposing highly innovative approaches to solving major challenges in biomedical research. Common Fund programs address high-priority opportunities that no single NIH Institute or Center is well-suited to address alone. Applications are due in September 2017.
Prospects Brighten for Biomedical Funding in the Federal Budget
The NIH will get a $2 billion funding boost over the next five months, under a bipartisan Congressional
spending agreement
reached April 30. The deal rejects President Trump's proposal to slash over $1 billion from the NIH budget in FY2107. NIH funding in FY2018, for which Trump seeks a nearly 20% reduction, remains to be addressed. The fact that lawmakers on both sides of the aisle came together to not only spare but also increase NIH funding reflects their shared recognition of its importance, as well as their intention to honor goals articulated in the
21st Century Cures Act
.
NYT: Science Needs Your Cells
Harvard Law School bioethicist Holly Fernandez Lynch, JD, MB, and Steven Joffe, MD, MPH, of the U Penn School of Medicine have published an
opinion piece in the New York Times
exploring the cultural, medical, legal and ethical aspects of research that depends heavily on specimens collected from human patients. This issue has been brought into the foreground by the imminent release of a film about Henrietta Lacks, from whose cervical cancer tissue HeLa cells were derived. Lynch and Joffe, focusing on the indispensable role played by such tissues in making progress against disease write: "Many aspects of Ms. Lacks's story reflect genuine injustice: the racism that characterized the health care system of her day; the suffering of her young family after her death; their own lack of access to health care. But should we be outraged by what happened to her cells, and could happen to our own? Actually, no."
|
|
Contacting Your Representatives Can Make a Difference for Science
If you are a U.S. citizen, let your U.S. representatives hear from you and encourage them to be advocating for science. There are many methods by which to reach out - from attending meetings or personal visits to congressional offices, to doing something as simple as writing a postcard. Be sure to reach out to your district and state representatives. Now, in addition to funding the NIH budget and other federal biomedical research budgets, scientists must clearly express how other policies impact scientific collaboration, a key component in the scientific process.
For more information on public policy affecting the scientific community and ways that you can help, please visit NAVBO's Advocacy page - www.navbo.org/resources/advocate
Here are links to organizations that encourage, support and aid science advocates:
Coalition for the Life Sciences
Federation of American Societies for Experimental Biology (FASEB)
Research!America
If you are aware of other groups, please let us know and we will post them in future newsletter issues (send to [email protected]).
|
|
|
