December 13, 2018
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Vascular Biology 
Monterey, CA  
October 27-31, 2019

Lymphatic Forum 2019
Austin, TX
May 31 - June 1, 2019

Vasculata 2019
Medical College of Wisconsin
July 13 - 18, 2019

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Corporate Members

VB2018 Supporters

UT Southwestern
Medical Center
VB2018 Exhibitors

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New NewsBEAT Feature
Over the next few issues we will feature interviews with the Travel Award recipients of Vascular Biology 2018.  We'll find out about their research interests, their meeting experiences and what they hope to accomplish. We welcome the chance to get to know these promising investigators and hope that their accounts will inspire other trainees...and their PIs! embrace the great opportunity that the Travel Awards representMembers of the Membership Committee will be conducting these interviews and we appreciate their efforts in bringing these young investigators into the limelight!
Meet Dr. Mabruka Alfaidi
Dr. Malbruka Alfaidi is a Postdoctoral Fellow in the Department of Pathology and Translational Pathobiology at LSU Health Sciences Center in Shreveport.  She presented a poster at Vascular Biology 2018 entitled, "The Differential Roles of the Adaptor Proteins Nck1 and Nck2 in Shear Stress-Induced Endothelial Activation in vitro and in vivo." 
How did you first learn about NAVBO?
I had originally wanted to attend the AHA meeting in 2014 to present my work outside the UK, but my mentor at the time, Dr. Sheila Francis, suggested that the NAVBO conference may be better-suited for what I wanted. Upon my abstract being selected to present an oral presentation, I've been a member since then.
Tell us about the research you presented and your mentor?
I was interested in different aspects of endothelial cell biology and when I attended NAVBO in 2014 I met Dr. Wayne Orr, who was investigating how endothelial cells responded to different types of shear stress. Along with Dr. Martin Schwartz, he defined how the extracellular matrix impacted proinflammatory responses and identified Pak and Nck as central players in these pathways-where Pak/Nck association promoted both NF-kB activation and endothelial cell permeability.  We've since identified various roles for different Nck isoforms in response to shear stress in vitro and in vivo.
What was your favorite event at the meeting?
The nanotalks were by far my favorite event - even though the talks were about 5 minutes long, I was able to learn so much.
Did you meet any people at the meeting who influence your research?
I met Dr. Masanori Aikawa, I've always looked up to him.  At my poster, I managed to talk and receive feedback from many scientists that have a great impact on my research, including Drs. Yun Fang, Filip Swirski, and Carlos Fernandez-Hernando.
What benefits did the travel award have for you?
The recognition was extremely positive. I received much more attention at my poster than I've had in previous meetings. Furthermore, because of the travel award, I'm now able to go to another meeting to further discuss my work. Without the NAVBO travel award, this would have been much more difficult.
What benefits can a trainee expect from attending NAVBO?
The culture that has been cultivated at NAVBO allows for great interactions between senior scientists and trainees, especially meetings at lunch and dinner times. The trainees get a lot of attention, which helps us move toward the next steps in our careers. In addition to attending meetings, I also feel like I contribute - something that has been very rewarding by having a one on one time during the poster sessions.
What future goals do you have for your work?
Build on the work I presented at the NAVBO meeting and publish the work. Also apply for different transition grants
And, how can NAVBO help you achieve these goals?
By presenting my work at the meeting, I received questions that I didn't consider before - this has allowed me to substantiate some of the results I got. I've also received advice from senior investigators that has allowed me to better strategize my career plans.
Contributor: Arif Yurdagul 
December Webinar with Tim Hla
Sphingosine 1-phosphate signaling: From the receptor, signaling  mechanisms to novel therapeutics
Please join us on December 20 at 1:00pmEST as NAVBO hosts our eighth webinar featuring Tim Hla of Boston Children's Hospital. 

The presentation entitled, "Sphingosine 1-phosphate signaling: from the receptor, signaling mechanisms to novel therapeutics," will feature the history, background and current research on sphingosine 1-phosphate biology.
Go to for more information and to register. 
Lab of the Month
The Lab of Dr. Joseph C. Wu

This month we are highlighting the lab of Dr. Joseph C. Wu, a Professor of Medicine and Radiology  at Stanford University School of Medicine. Find out more about Dr. Wu and his lab at 
Include NAVBO in Your Holiday Plans
Consider supporting NAVBO this year.  Here are three great ways to do it!

1) If you shop at Amazon - please use this link: You shop and .5% of your purchase will go to support NAVBO!  
2) Buy a NAVBO branded item - shirts, hoodies or mugs and help support  our educational initiatives. Go to, purchase a few and give them as holiday gifts to everyone in your lab!

3) Make a year-end tax deductible contribution - November 27, is Giving Tuesday.  NAVBO is a designated as a 501(c)3 charity by the IRS and therefore, your contribution to NAVBO is tax deductible.  Please donate here:  You can stipulate how you want your donation used.

Thank you!
Funding Opportunities from NHLBI
NHLBI Funding Opportunity - Deadline Approaching
The Vascular Biology and Hypertension Branch of NHLBI is seeking applications to the following funding opportunity:
RFA-HL-17-22: Maximizing the Scientific Value of the NHLBI Biorepository: Scientific Opportunities for exploratory Research (R21).

This funding opportunity is to support meritorious exploratory research relevant to the NHLBI mission using the biospecimen collections that are stored in the NHLBI Biorepository and that are available through BioLINCC.  

The due date for AIDS applications is January 7, 2019. Requests must be submitted to BioLINCC no later than December 17, 2018 in order to be eligible to receive a Letter of Availability by this due date.

For more information on RFA-HL-17-022 please visit:
To view available biospecimen collections and initiate a request, please visit:  
Spotlight on Trainees
Webinar to highlight Graduate STEM Ed Report from the National Academies
FASEB and the American Association of Medical Colleges are jointly hosting a webinar that will explore the key findings of this year's NAS report titled "Graduate STEM Education for the 21st Century." The webinar will focus on two central recommendations: 1) creating an incentive structure that supports quality mentoring and 2) building an institutional culture that values a full array of careers in the biomedical and medical workforce. The webinar will include examples of implementation that have been undertaken by several institutions. The webinar will be held on December 17, 1:00-2:00 PM ET; registration is free but required.  
Member News
Welcome to our New Member:
Julie Phillippi, University of Pittsburgh

If you have news to share with your colleagues, send it to
 Recent Publications by NAVBO Members

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model
Disease Models & Mechanisms
Tumour angiogenesis has long been a focus of anti-cancer therapy; however, anti-angiogenic cancer treatment strategies have had limited clinical success.  Read more


Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
New England Journal of Medicine
BACKGROUND: Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1β, resulted in a lower rate of cardiovascular events than placebo in a previous randomized trial.  Read more


Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure
Background: Subclinical inflammation associates with an increased risk of heart failure, and with adverse prognosis in patients with established heart failure.  Read more


Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction
Journal of Molecular and Cellular Cardiology
Background: Extracellular matrix metabolism and cardiac cell death participate centrally in myocardial infarction (MI). This study tested the roles of collagenolytic cathepsin K (CatK) in post-MI left ventricular remodeling.  Read more


Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade
Hemorrhagic shock (HS) is associated with low blood pressure due to excessive loss of circulating blood and causes both macrocirculatory and microcirculatory dysfunction.  Read more


Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in a Vascular Bed and Organ-Specific Way
Tie2 is a tyrosine kinase receptor that is mainly expressed by endothelial cells. In animal models mimicking critical illness, Tie2 levels in organs are temporarily reduced.  Read more


Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish (Danio rerio)
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective - Endothelial cells (ECs) sense and respond to flow-induced mechanical stress, in part, via microtubule-based projections called primary cilia.  Read more

Industry News
Call for papers from American Journal of Physiology
AJP-Heart and Circulatory Physiology has issued calls for original research papers and short reviews on the subjects of adaptive immunity  and chromatin biology and epigenetic regulation  in cardiovascular diseases. The first invitation, led by Guest Editors Drs. Kristine DeLeon-Pennell, Ganesh Halade, and Daria Ilatovskaya, seeks increase understanding of mechanisms of adaptive immunity associated with adverse cardiovascular events in the context of ischemic or non-ischemic cardiovascular disease (submissions due January 31, 2019). The second call, featuring Guest Editors Timothy McKinsey and Thomas Vondriska, invites manuscripts that assess effects of epigenetic regulators on cardiovascular phenotypes, emerging diagnostic parameters, and translational opportunities that may lead to novel clinical strategies (due February 15, 2019).
Ever failed to reproduce your own results?
The American Type Culture Collection is conducting a survey  aimed at gathering researchers' views on the 'reproducibility crisis' in the life sciences. ATCC has declared the goal of increasing the credibility of published work describing research conducted with their archival cell lines and biological reagents by employing the latest authentication techniques, developing advanced biological models, and making available the most reliable reference materials to investigators. "Only when you start with credible," says ATCC, "can you achieve the incredible."
Statins and abdominal aortic aneurysm
A new meta-analysis of abdominal aortic aneurysm (AAA), probing 911 studies searchable in COCHRANE, MEDLINE and EMBASE databases, has identified a potential benefit of the statin class of lipid-lowering agents in AAA complications. The study, published by Konrad Salata et al.
 in the Journal of the American Heart Association, founds that statin use was associated with improved disease progression, rupture and mortality parameters. In view of the favorable safety profile and relatively low cost of statin drugs, the authors suggest statin therapy may be indicated for AAA patients irrespective of their prevailing lipid profiles. 
Job Postings
Calendar of Events
April 3 - 6, 2019
Blood Brain Barrier
April 11 - 13, 2019
11th Congress of the Vascular Access Society
May 30 - June 1, 2019
Lymphatic Forum 2019
July 6 - 10, 2019
International Society on Thrombosis and Hemostasis Congress 2019
Oct. 27 - 31, 2019
Vascular Biology 2019
Sept. 9 - 12, 2020
IVBM 2020
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