June 22, 2017
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Vasculata 2017
Chicago, IL 
July 24-27, 2017
Registration is still open!   

Vascular Biology
Monterey, CA  
October 15-19, 2017
Abstract deadline: Aug 1 

20th IVBM
Helsinki, Finland
June 3-7, 2018 
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Cardiovascular Medicine
VB 2017 Supporters

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Welcome Reception Host

Gold Level

Strategic Partners

Meet the Professor Breakfasts Supported by

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Call for Postdocs!
NAVBO Education Committee Seeking Members 
I would like to draw your attention to a great new opportunity available for NAVBO Postdoctoral Fellow Members. The Education Committee is looking for Postdoctoral Fellows to provide ideas as to how NAVBO can best serve our trainee members. This is your opportunity to make a difference by enhancing the trainee membership experience. It will also provide you with the opportunity to interact with a great group of scientists while gaining leadership experience! If you're interested in joining us, please apply today.
Applicants should expect to serve a minimum of three years. Applications must include:  a current CV, a letter from your supervisor attesting to your leadership abilities, a brief statement from you concerning your commitment to the vascular biology community and this society, and what you would like to bring to this committee.  Please forward this information to  bernadette@navbo.org  by July 17, 2017.
If you have further questions about the Education Committee or the application process, please feel free to contact me (msmjmk33@gmail.com) or Bernadette ( bernadette@navbo.org ).
Thank you, 

Mary Jo Mulligan-Kehoe, Ph.D.
Education Committee Chair

Lymphatic Forum - A Success!
Here's what some attendees had to say about the meeting:
Excerpts from messages to Dr. Guillermo Oliver, key organizer of the meeting.

Thank you again for the invitation to the Lymphatic Forum. This was a spectacular meeting. I enjoyed it more than the GRC (maybe because I understand the lymphatics a bit better now, or the section of talks was simply better now).
- University of Virginia

Thank you for being a great host and  organizing an outstanding conference  - I enjoyed it very much, brilliant idea for poster teasers! The quality of posters was also amazing.  I hope that the next  Lymphatic Forum in 2019 will uphold the great standards you set in this meeting.
- University of Lausanne

Thank you for organizing such a wonderful and exciting meeting! It was one of the best meetings I've ever attended. I really had a great time and in the meantime, learned so much! Everything was fantastic!
- Boston Children's Hospital, Harvard Medical School

Just wanted to thank you for the opportunity to participate in the forum.  It was a fantastic meeting from every perspective - the gorgeous setting on the lake, the great science, and the format which allowed lots of time for informal conversation.  I came away with two new collaborations that may lead to new models of LAM, and lots of new ideas.  Truly one of the most productive and fun meetings I have ever attended.  Thank you for all you are doing for lymphatic biology research and for LAM!
- Brigham and Women's Hospital, Harvard Medical School 
Read more reviews by NAVBO Travel Award Winners:
Maike Frye, Postdoc, University of Uppsala
Sawan Kumar Jha, University of Helsinki
Hasina Outtz Reed, University of Pennsylvania
Yixin Wang, Karolinska Institute
Wenjing Xu, University of North Carolina at Chapel Hill
NAVBO Deadlines to Watch For
NAVBO Council Elections
Vote by June 30
(restricted to regular members in good standing)

Meritorious Award Nominations

Travel Awards to the GRC on Angiogenesis
Application deadline extended to July 10
Go to: http://www.navbo.org/awards/trainee-awards/travel-awards-to-grc for information and criteria

Vascular Biology 2017
Abstract deadline - August 1
Early bird discount - August 15

Lab of the Month
The Lab of Dr. Pierre-Yves von der Weid
This month we are highlighting the lab of Dr. Pierre-Yves von der Weid, who is an Associate Professor in the Department of Physiology and Pharmacology at the University of Calgary. Find out more about Dr. von der Weid and his lab at http://www.navbo.org/membership/members-labs/616-lab062017.
Spotlight on Trainees (from June 8 issue)
Experimental Elegance Illuminates Nature's Complexity
This spring, Princeton University President Emerita and eminent molecular biologist Shirley M. Tilghman has taught a new freshman seminar, "What Makes a Great Experiment?" Each week, Tilghman selects for class discussion, often accompanied by other leading scientists, a paper she feels is thoughtfully and creatively designed and written for publication. Quoted in a Princeton news release, Dr. Tilghman notes: "My goal with the class is to explore with students - not all of whom are likely to be science concentrators - how scientific discovery happens...[t]oo often, science classes become a series of facts to be memorized without any understanding of how that knowledge has been generated. I am also trying to impart a sense of the aesthetic beauty of conducting good science - how beautiful a great experiment can be."
Member News
Welcome to our Newest Members:
Angela Crist, Tulane University
Matias Ekstrand, University of Gothenburg
Bryan Fioret, United Therapeutics
Luis Hortells, University of Pittsburgh
Wenquan Hu, Medical College of Wisconsin
Ashraf Ul Kabir, Washington University in St. Louis
Philip King, University of Michigan
Michelle LeBlanc, Schepens Eye Research Institute
Viktorija Reinikovaite, Medical College of Wisconsin
If you have news to share with your colleagues, send it to membership@navbo.org.
 Recent Publications by NAVBO Members

Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution
Molecular Biology of the Cell
Endothelial cells line the lumen of the vessel wall and are exposed to flow. In linear parts of the vessel, the endothelial cells experience laminar flow, resulting in endothelial cell alignment in the direction of flow, thereby protecting the vessel wall from inflammation and permeability.  Read more


Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits
Cell Reports
This was a collaboration or Dritan Agalliu, Columbia University and Leslie Thompson, University of California, Irvine, an expert in Huntington's disease. While BBB dysfunction exists in neurological disorders, including Huntington's disease (HD), it is not known if BMECs themselves are functionally compromised to promote BBB dysfunction. Further, the underlying mechanisms of BBB dysfunction remain elusive given limitations with mouse models and post-mortem tissue to identify primary deficits. In this study, the authors undertook a transcriptome and functional analysis of human induced pluripotent stem cell (iPSC)-derived BMECs (iBMEC) from HD patients or unaffected controls. They demonstrate that HD iBMECs have intrinsic abnormalities in angiogenesis and barrier properties, as well as in signaling pathways governing these processes. Thus, their findings provide an iPSC-derived BBB model for a neurodegenerative disease and demonstrate autonomous neurovascular deficits that may underlie HD pathology with implications for therapeutics and drug delivery. This paper will pave the way for our understanding of how BBB dysfunction is mediated in other neurological disorders such as Alzheimer's disease using an iPSC-based approach to generate brain endothelial cells  Read more


A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27Kip1) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells
Journal of Vascular Surgery
BACKGROUND: Cyclin-dependent kinase inhibitor 1B (p27Kip1) is a cell-cycle inhibitor whose -838C>A single nucleotide polymorphism (rs36228499; hereafter called p27 SNP) has been associated with the clinical failure of peripheral vein grafts, but the functional effects of this SNP have not been demonstrated.  Read more


Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature
Cell Reports
Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin.  Read more


Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina
Arteriosclerosis, Thrombosis, and Vascular Biology
OBJECTIVE: Laminar flow activates myocyte enhancer factor 2 (MEF2) transcription factors in vitro to induce expression of atheroprotective genes in the endothelium. Here we sought to establish the role of Mef2c in the vascular endothelium in vivo.  Read more


Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks
Nature Biomedical Engineering
Notwithstanding the remarkable progress in vascular network engineering, implanted bioengineered microvessels mostly fail to form anastomoses with the host vasculature.  Read more

Industry News (from June 8 issue)
Indirect Costs under the Microscope?
In mid-May, the US House Appropriations Subcommittee on Labor, Health and Human Services held a hearing focused on the NIH and advances in biomedical research. NIH Director Francis Collins and the Directors of individual NIH Institutes, including NHLBI Director Gary Gibbons, were present to testify to the need to support increased funding for NIH, to accelerate lifesaving biomedical research and recruit and retain young researchers in the pipeline. Subcommittee members expressed concern about ongoing budgetary battles and their effects on the NIH. Later in the month, the House Committee on Science, Space, and Technology held a joint Research and Technology Subcommittee and Oversight Subcommittee hearing on examining the overhead costs of research. During the hearing,  participants discussed factors and considerations that reflect the diverse indirect cost rates negotiated between institutions and the federal government related to research supported by agencies including the NIH and NSF, noting that negotiated rates do not allow some institutions to cover all of the costs to support cutting-edge research programs.

Performance Evaluations Tied to Equity Efforts?
A new policy at the University of Wisconsin-Eau Claire will require all faculty and staff members to work toward equity, diversity and inclusion, with the results factored into their evaluations. Big-budget diversity initiatives on a number of campuses have drawn praise and skepticism in recent years. What if there was a more efficient, inexpensive way for institutions to live up to their diversity and inclusion goals? UW- Eau Claire may have one. "After 30 years in administration, I don't have much tolerance for window dressing or lip service. If you're going to put a value out there, you need to do something with it," said Chancellor James Schmidt in Inside Higher Ed. Schmidt champions the new policy requiring that all periodic evaluations of staff and faculty members -- including tenure and promotion decisions -- consider the employee's contributions to equity, diversity and inclusion on campus.

Staff Scientists Vital to the Research Enterprise
In a comment in Nature Journal, Steven Hyman, MD, of the Broad Institute argues that independent professionals advance science in ways faculty-run labs cannot, and that such positions keep talented people in research. He highlights new organizational principles being implemented in labs at HHMI, Salk, and elsewhere, noting that this has taken not only access to resources but a willingness to overcome cultural norms in science. He writes, "Although traditional academic labs have been and continue to be very productive, research institutions should look critically and creatively at their staffing... If adopted judiciously, these positions would enable institutions to take on projects of unprecedented scope and scale."

Job Postings
Calendar of Events
July 8-13, 2017
International Society on Thrombosis and Haemostasis 2017 Congress
July 24-27, 2017
Vasculata 2017
Aug. 11-14, 2017
2017 APS Conference: Cardiovascular Aging, New Frontiers and Old Friends
Sept. 27-28, 2017
2017 NHLBI Symposium on Cardiovascular Regenerative Medicine
Oct. 15-19, 2017
Vascular Biology 2017
June 3-7, 2018
20th International Vascular Biology Meeting
Advocating for Science
Contacting Your Representatives Can Make a Difference for Science
If you are a U.S. citizen, let your U.S. representatives hear from you and encourage them to be advocating for science. There are many methods by which to reach out -  from attending meetings or personal visits to congressional offices, to doing something as simple as writing a postcard.  Be sure to reach out to your district and state representatives. Now, in addition to funding the NIH budget and other federal biomedical research budgets, scientists must clearly express how other policies impact scientific collaboration, a key component in the scientific process.

For more information on public policy affecting the scientific community and ways that you can help, please visit NAVBO's Advocacy page - www.navbo.org/resources/advocate

Here are links to organizations that encourage, support and aid science advocates:
Coalition for the Life Sciences
Federation of American Societies for Experimental Biology (FASEB)

If you are aware  of other groups, please let us know and we will post them in future newsletter issues (send to info@navbo.org). 
North American Vascular Biology Organization | bernadette@navbo.org | http://www.navbo.org
18501 Kingshill Road
Germantown, MD 20874-2211